PRODH antibody Polyclonal Antibodies Primary antibodies
- Known as:
- PRODH (anti-) Polyclonal Antibodies Primary antibodies
- Catalog number:
- orb100680
- Product Quantity:
- 100
- Category:
- -
- Supplier:
- Biorb
- Gene target:
- PRODH antibody Polyclonal Antibodies Primary antibodies
Related genes to: PRODH antibody Polyclonal Antibodies Primary antibodies
- Gene:
- PRODH NIH gene
- Name:
- proline dehydrogenase 1
- Previous symbol:
- -
- Synonyms:
- HSPOX2, PRODH1, PIG6, PRODH2, TP53I6
- Chromosome:
- 22q11.21
- Locus Type:
- gene with protein product
- Date approved:
- 1996-12-12
- Date modifiied:
- 2016-10-05
Related products to: PRODH antibody Polyclonal Antibodies Primary antibodies
Related articles to: PRODH antibody Polyclonal Antibodies Primary antibodies
- Saline-alkali stress is a major factor limiting oat growth in various parts of the world. Amino acids, which are essential structural and metabolic compounds in plants, play a crucial role in enhancing salt tolerance. During abiotic stress, amino acids such as proline, arginine and asparagine are synthesised to serve as compatible osmotic regulators, precursors for secondary metabolites, or organic nitrogen storage compounds. In this study, we examined the effect of salt-alkali stress on amino acid metabolism in two oat varieties. Transcriptomic, proteomic and metabolomic analyses were performed to identify amino acid metabolism-related genes, proteins and metabolites in salt-sensitive and salt-tolerant oats after 6, 12, 24 and 48 h of saline-alkali stress. Saline-alkali stress significantly affected five groups of amino acids: oxaloacetate, glycerate, aromatic, pyruvate and α-ketoglutarate. Among the amino acids identified, phenylalanine and tyrosine showed relatively high expression levels at the transcriptome, proteome and metabolome levels. Genes related to amino acids, including cysK, SHMT, PAL and TDC (amino acid content regulators), were differentially expressed between the two oat varieties and amino acid metabolites such as L-glutamate, L-asparagine, L-aspartic acid, glutathione and betaine were differentially regulated. Key genes, including ASNS, serA, PRODH and cysK, were significantly differentially expressed in both varieties under stress, as validated by RT-qPCR. This study provides a comprehensive analysis of amino acid metabolism in two oat varieties with different salt tolerances and offers insights into the regulatory mechanisms of amino acid metabolism under abiotic stress. - Source: PubMed
Ling LeiXing ShuyaLi JiaSong JiaxinZhang YaoyueLu Shutong - A significant proportion of individuals who are heavily exposed to infectious tuberculosis patients do not acquire Mycobacterium tuberculosis (Mtb) infection, as detected by an interferon gamma release assay (IGRA). We examined circulating metabolite profiles and metabolic genotypes in 199 heavily exposed IGRA-negative tuberculosis household contacts in Indonesia. Based on differentially abundant metabolites, activity of several pathways including arachidonic acid, arginine and proline, glutathione, and tryptophan metabolism, correlated with a negative IGRA at three months. SNPs near PRODH (involved in arginine and proline metabolism) were associated with circulating proline concentrations and persistently negative IGRA results, while SNPstudys near AFMID (involved in tryptophan metabolism) were associated with IGRA conversion. For further validation, plasma metabolomic profiles were correlated with mycobacterial growth inhibition by peripheral blood mononuclear cells from individuals in a low-incidence setting. Lower circulating concentrations of six metabolites, including leukotriene B4, proline, glycine, and tryptophan correlated with better growth control in non-exposed healthy individuals, as well as with stronger protection against IGRA-conversion in the Indonesian tuberculosis household contacts. Collectively, these data support the notion that circulating metabolites may impact innate host defense against Mtb infection, and that metabolic interventions may prevent tuberculosis infection and disease. - Source: PubMed
Publication date: 2026/05/21
Setiabudiawan Todia PApriani LikaAvila-Pacheco JulianArdiansyah EdwinKumar VinodAlisjahbana BachtiVerrall Ayesha JDiNardo Andrew RIndrati Agnes RMourits Vera Pde Bree L Charlotte JMoorlag Simone J C F MClish Clary BJoosten Leo A Bvan Laarhoven Arjanvan Meijgaarden Krista ENetea Mihai GJoosten Simone AKoeken Valerie A C MHill Philip Cvan Crevel Reinout - Depression is a common psychiatric disorder characterized mainly by low mood, anhedonia, and sleep disturbances. In severe cases, it can lead to suicidal tendencies and behaviors. Chronic stress can induce depressive symptoms in some individuals, while others do not respond from stressful experiences, which may represent an intrinsic mechanism underlying resistance to external stressors. The molecular mechanism underlying this resilience remains elusive. - Source: PubMed
Publication date: 2026/05/20
Chen XiaoyuCao YiZhao XianlongLi YangSong ZhenhuaWang JuntaoPan Dong - Hyperprolinemia type I (HP1) is a rare autosomal recessive disorder caused by biallelic variants in PRODH, encoding the FAD-dependent enzyme proline dehydrogenase. Although persistent hyperprolinemia has been associated with neurodevelopmental and neuropsychiatric manifestations, no established effective treatment is available. Here, we report convergent clinical and patient-derived fibroblast evidence supporting riboflavin responsiveness in HP1 due to a homozygous PRODH c.1397C>T p.(Thr466Met) variant. The patient exhibited markedly elevated plasma proline (530-625 μmol/L; reference 78-273 μmol/L), which decreased after initiation of a vitamin cocktail including riboflavin (291 and 277 μmol/L at 3 and 8 months) and decreased on riboflavin monotherapy (251 μmol/L; 12 mg/day). Urinary P5C became slightly detectable during riboflavin supplementation and was not detectable after riboflavin discontinuation. In patient-derived fibroblasts, intracellular proline was elevated compared with a control and was reduced by riboflavin therapy (40.32 to 14.85 pmol/200 μL PBS; control 21.65 pmol/200 μL PBS). PRODH mRNA showed a modest upward trend under riboflavin in fibroblasts. Although direct enzymatic activity could not be reliably assessed due to technical limitations, these multi-level findings support riboflavin as a potential cofactor-directed therapy in selected PRODH missense variants and provide a rationale for therapeutic trials with biochemical monitoring. - Source: PubMed
Publication date: 2026/05/13
Kido JunSugawara KeishinEgashira IkukoYano NaomiZhang ChunhuaNakamura Kimitoshi - Fusarium graminearum poses a major threat to global cereal production, necessitating sustainable control measures. This study elucidates the antagonistic mechanism of the biocontrol agent Bacillus velezensis EU07 against F. graminearum through combined transcriptomic and morphological analyses. Exposure to EU07 compromised fungal cellular integrity, causing severe hyphal distortion. RNA-seq profiling revealed that EU07 triggers a profound transcriptomic collapse rather than a standard stress response. Over 35% of the altered fungal transcriptome caused critical suppression, targeting essential metabolic hubs, secretome effectors, and master transcription factors to inhibit growth and loss of pathogenicity. In a compensatory defensive shift, the pathogen massively reallocated its transcriptional resources. This defence was characterised by a ~ 30-fold enrichment of transmembrane amino acid transporters for putative toxin efflux and an 80-fold enrichment of glutathione S-transferases to mitigate severe oxidative stress. Furthermore, EU07 suppressed core vulnerability nodes, including proline dehydrogenase (PRODH) and apolipophorin, disrupting the pathogen's osmotic resilience and membrane integrity. Molecular docking analysis indicated that the Bacillus lipopeptide iturin A directly targets apolipophorin with high affinity (- 7.2 kcal/mol). Our findings indicated that B. velezensis EU07 overwhelms F. graminearum through simultaneous metabolic starvation and loss of virulence, revealing highly vulnerable fungal targets for next-generation RNAi-based biocontrol. - Source: PubMed
Publication date: 2026/05/08
Baysal ÖmürJimenez-Quiros CatherineCevher-Keskin BirsenTör Mahmut