CD161 antibody Polyclonal Antibodies Primary antibodies
- Known as:
- CD161 (anti-) Polyclonal Antibodies Primary antibodies
- Catalog number:
- orb100571
- Product Quantity:
- 100
- Category:
- -
- Supplier:
- Biorb
- Gene target:
- CD161 antibody Polyclonal Antibodies Primary antibodies
Related genes to: CD161 antibody Polyclonal Antibodies Primary antibodies
- Gene:
- KLRB1 NIH gene
- Name:
- killer cell lectin like receptor B1
- Previous symbol:
- NKR
- Synonyms:
- CD161, NKR-P1, NKR-P1A, hNKR-P1A, CLEC5B
- Chromosome:
- 12p13.31
- Locus Type:
- gene with protein product
- Date approved:
- 1998-01-16
- Date modifiied:
- 2016-10-05
Related products to: CD161 antibody Polyclonal Antibodies Primary antibodies
Related articles to: CD161 antibody Polyclonal Antibodies Primary antibodies
- Neuroblastoma is a pediatric malignancy characterized by significant clinical heterogeneity. Although MYCN amplification is a well-established marker of high-risk disease, its interplay with the tumor immune microenvironment-particularly tumor-associated macrophages (TAMs)-remains poorly understood. In this study, we developed an integrated gene signature incorporating genes associated with both MYCN amplification status and TAM infiltration, leading to the identification of 16 differentially expressed genes implicated in both biological processes. Six of these genes (CMBL, LY6E, KLRB1, CTSH, CD3D, and PTGDS) were utilized to construct a risk-scoring model that effectively stratified neuroblastoma patients into high- and low-risk groups with significantly distinct clinical outcomes ( < 0.001). Notably, LY6E emerged as the most prognostically significant gene within the signature. More importantly, we revealed that LY6E modulates M2-type macrophage polarization in neuroblastoma for the first time, suggesting a novel mechanism through which it may contribute to shaping an immunosuppressive tumor microenvironment. - Source: PubMed
Publication date: 2026/04/15
Li LijuanZeng YuZhang QinfenZhuang GaojianLiu YuWang XuanWang Yuqi - Rheumatoid arthritis (RA) is a systemic autoimmune inflammatory disorder. KLRB1 (killer cell lectin like receptor B1), which is intricately linked to immune modulation and inflammatory responses, represents a promising biomarker for the identification of RA. This study mainly explores the relationship between KLRB1 and RA, and identifies biomarkers related to KLRB1 in RA, providing theoretical support for the diagnosis and treatment of RA. - Source: PubMed
Publication date: 2026/04/09
Song JialeLu JunqinZhao HaoyuSong FeiZhou WeiZhou Jian - We sought to determine changes in the expression of immune response-related genes occurring in surgical necrotizing enterocolitis (NEC) tissues from infants with necrosis severity and survival status. - Source: PubMed
Publication date: 2026/03/24
Garg Parvesh MohanRiddick RobinZhang PengboShenberger JeffreyVarshney NehaSawaya DavidGarg Padma - HPV status is a key prognostic determinant in head and neck squamous cell carcinoma (HNSCC), yet the immunological mechanisms underlying the survival advantage of HPV-positive (HPV) over HPV-negative (HPV) disease remain poorly defined. This study aimed to characterize the tumor-infiltrating natural killer (NK) cell landscape in HPV-stratified HNSCC and identify novel therapeutic targets. We performed an NK-cell-centric re-analysis of published scRNA-seq data from 28 HNSCC patients (10 HPV, 18 HPV; GEO: GSE139324, GSE164690), encompassing NK subset identification, pseudotime trajectory inference, and cell-cell interaction analysis. Key findings were validated by immunohistochemistry (IHC) in an independent cohort of 10 FFPE tissue sections, and prognostic associations were assessed using TCGA-HNSC data. Four transcriptionally distinct NK cell subsets were identified: adaptive, cell-killing, CD56, and virus-responsive. A cytotoxic CX3CR1KLRB1 NK subset was specifically enriched in HPV tumors and independently associated with favorable survival. Conversely, HPV tumors upregulated CLEC2C and CLEC2D ligands on tumor cell surfaces, engaging the inhibitory receptor KLRB1 on NK cells; this CLEC2-KLRB1 axis correlated with suppressed NK activity and poorer prognosis, and was confirmed at the protein level by IHC. NK cell function in HNSCC is dichotomously regulated by HPV status. The CX3CR1KLRB1 subset represents a candidate prognostic biomarker in HPV disease, and the CLEC2-KLRB1 axis is a targetable immune evasion mechanism in HPV HNSCC. These insights support the development of HPV-stratified immunotherapies; however, clinical translation requires validation in large, prospectively designed, subsite-matched cohorts to disentangle HPV-specific effects from anatomical site-dependent immune contextures. - Source: PubMed
Publication date: 2026/03/05
Li RuiTong FangjiaLiu HuanLiu ZengchenLi WanlinZhang YingdongPeng YimanPan ShuangWei LanlanLi NingChu Ming - Invasive lobular carcinoma (ILC) accounts for 15% of breast cancers and presents challenges such as chemotherapy resistance and poorer survival outcomes compared to other subtypes. While often managed similarly to invasive ductal carcinoma (IDC), ILC requires tailored approaches due to its distinct biology. Ferroptosis, an iron-dependent form of cell death, shows potential in overcoming therapeutic resistance but remains unexplored in ILC. This study aimed to identify ferroptosis-related molecular subtypes, develop a robust gene signature using machine learning, construct an integrated prognostic model, and uncover potential therapeutic targets for ILC. - Source: PubMed
Publication date: 2026/02/25
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