FMNL1 antibody Polyclonal Antibodies Primary antibodies
- Known as:
- FMNL1 (anti-) Polyclonal Antibodies Primary antibodies
- Catalog number:
- orb100567
- Product Quantity:
- 100
- Category:
- -
- Supplier:
- Biorb
- Gene target:
- FMNL1 antibody Polyclonal Antibodies Primary antibodies
Related genes to: FMNL1 antibody Polyclonal Antibodies Primary antibodies
- Gene:
- FMNL1 NIH gene
- Name:
- formin like 1
- Previous symbol:
- C17orf1B, FMNL
- Synonyms:
- C17orf1
- Chromosome:
- 17q21.31
- Locus Type:
- gene with protein product
- Date approved:
- 1999-06-25
- Date modifiied:
- 2015-11-12
Related products to: FMNL1 antibody Polyclonal Antibodies Primary antibodies
Related articles to: FMNL1 antibody Polyclonal Antibodies Primary antibodies
- Renal cell carcinoma (RCC) is a prevalent and heterogeneous malignancy with clear cell RCC (ccRCC) as the most common subtype. Despite advances in surgical, targeted, and immunotherapeutic approaches, prognosis for advanced and metastatic RCC remains poor, and the effectiveness of current immunotherapies is limited by immune tolerance, tumor heterogeneity, and adverse effects. The identification of tumor-associated antigens (TAAs) and tumor-specific antigens (TSAs) is crucial for the development of personalized and effective antigen-directed therapies, including vaccines, antibodies and adoptive cell therapies. This review summarizes epidemiological data, molecular features of RCC, and the role of the von Hippel Lindau - Hypoxia Inducible Factor (VHL-HIF) signaling pathway in pathogenesis, alongside recent progress in characterizing possible antigen targets for vaccination such as TOP2A, NCF4, FMNL1, DOK3, MUC1, CAIX, CD70, and 5T4. Preclinical models, including genetically engineered mouse models, zebrafish, and various patient-derived xenograft (PDX) systems, are discussed as tools for studying tumor biology and testing immunotherapeutic strategies. Clinical trial data on RCC vaccines, including autologous renal tumor cell vaccination, peptide-based, dendritic cell-based, and viral vector platforms, demonstrate immunogenicity but have not yet yielded clear survival benefits in phase III trials. Future directions emphasize integrating antigen discovery with immune profiling, refining preclinical modeling, and developing personalized vaccines to enhance therapeutic efficacy, particularly for immunologically favorable patient subtypes and for certain applications such as reducing metastasis after surgery. In particular, we discuss carrier-based vaccine approaches for overcoming tolerance and increasing the immunogenicity of vaccines. - Source: PubMed
Publication date: 2026/03/27
Kagirova EvelinaEnikeeva KadriiaMukhamadeev RadmirAsadullina DilaraSharifyanova YuliyaShmelkova PolinaGainullina DianaTrifonova DariaGattinger PiaDocena GuillermoDubovets AlexandraTulaeva InnaKaraulov AlexanderValenta RudolfPavlov Valentin - Langya chickens, a Chinese indigenous breed, exhibit rich genetic resources but relatively low egg production performance. To investigate the genetic basis of egg production traits, we performed low-depth genome resequencing of 1,183 Langya hens and evaluated six phenotypic traits, including age at first egg (AFE), egg number at different laying stages-EN1 (from first egg to 26 weeks), EN2 (27-36 weeks), EN3 (37-43 weeks), total egg number at 43 weeks (E43), and maximal clutch length (MCL). Genetic parameter analysis revealed that MCL exhibited high heritability (0.42) and strong genetic correlations with both egg production and AFE, suggesting its potential as a more effective selection indicator for egg production traits. Genome-wide association studies identified a total of 245 SNPs associated with these traits. Notably, a 6.58 Mb region on chromosome 5 (GGA5, 40.03-46.61 Mb) was enriched for multiple traits and in strong linkage disequilibrium. Candidate genes in this core region, including TSHR, GTF2A1, DIO2, STON2, NRXN3, KCNK10, EML5, and FOXN3, were implicated in transcriptional regulation, thyroid hormone signaling, neuroendocrine modulation, and ovarian function. Additional trait-specific candidate genes, such as ATG2B for EN2, FMNL1 for EN1/EN2, TDP1 for E43, and TPMT for MCL, were also identified. Functional enrichment analyses highlighted pathways related to cellular processes, lipid metabolism, and signal transduction. These findings provide genomic insights into the molecular mechanisms underlying egg production traits and offer valuable candidate genes for marker-assisted breeding in Langya chickens. - Source: PubMed
Publication date: 2026/01/04
Zhang HongruiFu YuanjieWang YanlinYin SijingJiang YunliangSun YiKang Li - Prostate cancer is a clinically heterogeneous disease. Since PSA is not cancer-specific, and due to the bone metastases seen in the advanced stage and bone deformations caused by hormone therapy, it is necessary to use new biomarkers. Formin-like-protein 1 (FMNL1), a member of the formin protein family, is of great importance in actin polymerization, cell attachment, and migration processes. p21-activated kinase 1 (PAK1) proteins, members of the PAK protein kinases, play a role in cytoskeletal organization, as well as regulating other cellular activities such as cell survival, mitosis, and transcription. In our study, plasma and urine samples of 60 prostate cancer patients and 20 healthy controls were studied using RT-PCR and ELISA methods. No statistical difference was found between FMNL1 mRNA and protein expression levels of patients and controls in both plasma and urine samples ( > 0.05). There was no statistical difference between PAK1 mRNA expression levels of patients and controls in plasma and urine samples ( > 0.05). While no significant difference was found in PAK1 protein levels in plasma samples ( > 0.05), it was found to be lower in urine samples of patients compared to the control group ( = 0.00). Both marker molecules have low expression levels in early-stage PCa. - Source: PubMed
Publication date: 2025/08/13
Bilgin Doğru ElifErdem SelçukOğuz Soydinç Hilalİribaş AyçaDuranyıldız Derya - Endocytic recycling pathways play key roles in a broad range of cellular processes, and many vesicle trafficking regulators are implicated in progression of disease such as cancer. The Rab11 family (Rab11a, Rab11b, and Rab25) controls the return of internalized cargos to the plasma membrane, and Rab25 has been implicated in the aggressiveness of cancer by promoting invasive migration. However, while Rab25 vesicles distribute to the leading edge of moving cells, how directly they contribute to cell protrusion is not clear. Here, we adopt a magnetogenetic approach that allows direct manipulation of Rab25 positioning to show that localization to the cell periphery drives the formation of F-actin protrusions. We demonstrate that endogenous Rab25 vesicles coordinate the positioning of key cargos, including the actin regulator FMNL1 and integrin β1, with the activation of Rho guanosine triphosphatases at the plasma membrane to generate and maintain F-actin-rich filopodium-like protrusions and promote cancer cell invasive migration in the three-dimensional matrix. - Source: PubMed
Publication date: 2025/07/04
Gemperle JakubLiße DomenikKappen MarieSecret EmilieCoppey MathieuGregor MartinMenager ChristinePiehler JacobCaswell Patrick - Long noncoding RNAs (lncRNAs) influence the progression, metastasis, and drug resistance of various cancers including ovarian cancer (OC). Putative G-quadruplex (G4)-forming sequences that are abundant in cancer-dysregulated lncRNAs have not been systematically pursued from a structure-function correlation perspective. In this work, we have used a combination of informatics, computational tools, spectroscopy, and molecular biology experiments to identify G4 formation by the OC-dysregulated lncRNAs ERLNC1, DLX6-AS1, LINC01127, FMNL1-DT, and LINP1. The in vitro ability of the lncRNAs to fold into G4 structures was accompanied by interesting profiles of individual G-tract contributions and response to monovalent cations, ligand TMPyP4, and G4-targeting antibody. Human serum albumin (HSA) was found to interact with these G4-forming lncRNAs, albeit with different affinities and structural implications for the G4 motifs. The G4-motif likely plays a crucial role in the binding interactions of select lncRNAs with HSA. This study provides the first systematic study of putative G4-forming sequences in OC-dysregulated lncRNAs and elucidates their interactions with HSA. The interaction of lncRNAs with HSA, possibly facilitated by G4 motifs, can be valuable for OC diagnosis and therapeutics. - Source: PubMed
Publication date: 2025/06/11
Singh DeepshikhaShukla ChinmayeeDatta Bhaskar