Nrf2 Polyclonal pAb
- Known as:
- Nrf2 Polyclonal pAb
- Catalog number:
- ASAKAP-TF125F
- Product Quantity:
- 200 µg
- Category:
- -
- Supplier:
- Other suppliers
- Gene target:
- Nrf2 Polyclonal pAb
Related genes to: Nrf2 Polyclonal pAb
- Gene:
- KEAP1 NIH gene
- Name:
- kelch like ECH associated protein 1
- Previous symbol:
- -
- Synonyms:
- KIAA0132, MGC10630, MGC1114, MGC20887, MGC4407, MGC9454, INrf2, KLHL19
- Chromosome:
- 19p13.2
- Locus Type:
- gene with protein product
- Date approved:
- 2003-09-30
- Date modifiied:
- 2015-11-23
Related products to: Nrf2 Polyclonal pAb
Related articles to: Nrf2 Polyclonal pAb
- This work has achieved, for the first time, the unveiling of novel antioxidant peptides from silver carp bone collagen (SCBC) and their underlying multi-dimensional mechanism by integrating , , and approaches. AEDVN, EDDR, and DVEL were identified from SCBC with good DPPH-scavenging activity (IC = 0.89-2.59 mM), strong Fe-chelating ability (IC = 0.98-3.72 mM), and high stability against simulated gastrointestinal digestion. The acylamino, guanidinium, and N-terminal amino groups can be their dominant redox active sites, respectively. They could form strong hydrogen bonds and electrostatic attractions with core residues (such as ARG380, ARG415, and ARG483) of Kelch domain within Keap1, thereby activating the Keap1-Nfr2-ARE antioxidant pathway. Therefore, the activities of superoxide dismutase, catalase, and glutathione peroxidase were significantly increased, resulting in the malondialdehyde reduction and cell viability improvement against HO-induced oxidative damage. These findings provided a cost-effective and time-saving strategy for high-value utilization of fish by-product bones as natural antioxidant sources. - Source: PubMed
Publication date: 2026/06/06
Mei YimengLin FengXie RuoyuChen JiaxinHu JunChen WenxuanDu HongyingHao GuijieLi ShuangxiZhang Jin - Drug-induced liver injury (DILI) is a global health issue with limited treatment options. The nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway plays a critical role in defending against DILI, making it a potential therapeutic target. - Source: PubMed
Publication date: 2026/06/11
Zhang ZeGu XinnanZhu GuanghaoMeng YuWei MengjuanChu XiayanLuo YuxuanHuang ZhenlinGe GuangboJi Lili - Neurodegenerative diseases, including Alzheimer's, Parkinson's, and Huntington's diseases, are characterized by progressive neuronal dysfunction and loss. Recent evidence highlights the importance of the nuclear factor erythroid 2-related factor 2 (NRF2) pathway, a key regulator of cellular defense mechanisms, in maintaining neuronal health and function. A narrative literature search was conducted using PubMed, Scopus, Web of Science, and Google Scholar to identify relevant experimental, clinical, and review studies on NRF2 signaling, physical exercise, oxidative stress, muscle-brain crosstalk, and neurodegenerative diseases. Keywords included "NRF2", "Nrf2/Keap1/ARE", "physical exercise", "exercise-induced oxidative stress", "myokines", "exerkines", "Alzheimer's disease", "Parkinson's disease", "Huntington's disease", and "amyotrophic lateral sclerosis". NRF2 modulates the expression of a variety of antioxidant and cytoprotective genes, contributing to the protection of neurons against oxidative stress, inflammation, and protein aggregation, processes central to the pathogenesis of neurodegenerative diseases. Additionally, physical activity has been identified as a powerful modulator of NRF2 activation, with exercise offering neuroprotective effects through the induction of NRF2-mediated pathways. This review explores the interplay between NRF2 activation and physical exercise in the context of neurodegenerative diseases, detailing the molecular mechanisms by which exercise influences NRF2 activity to combat cellular damage and enhance neuroprotection. We discuss the therapeutic potential of combining exercise regimens with NRF2-targeted therapies, highlighting the promise of this dual approach in slowing disease progression, improving cognitive function, and enhancing quality of life in affected individuals. Furthermore, we examine the challenges and future directions for clinical implementation, including optimal exercise protocols and the development of NRF2-based pharmacological interventions. This review underscores the importance of NRF2 as a central mediator of neuroprotection and the therapeutic promise of physical activity in the management of neurodegenerative diseases. - Source: PubMed
Publication date: 2026/06/18
Deng PichaoDeng WeiWang LinyaoYe WeiwuLi Shihong - Commercial crustacean species represent some of the most economically valuable fishery products; however, their full potential remains underexploited due to the routine disposal of shellfish waste, which is rich in high-value bioactive compounds. Among these, carotenoid pigments have garnered increasing interest for their antioxidant and anti-inflammatory properties. In this study, we investigate the potential of recovering bioactive compounds from the shells of the European lobster ( Linnaeus, 1758) and the Atlantic blue crab ( Rathbun, 1896), with a particular focus on carotenoprotein complexes with promising applications in the pharmaceutical and cosmetic industries. We adopted a computational approach integrating protein contact networks, molecular docking, and molecular dynamics simulations to characterize the structural and functional properties of crustacean carotenoproteins as nanocarriers for astaxanthin. Then, we explored in silico the antioxidant activity of astaxanthin, as claimed by many studies. Specifically, we applied the computational analyses to the interaction between astaxanthin and Kelch-like ECH-associated protein 1 (Keap1-DC domain), a key regulator of the Nrf2 signaling pathway involved in oxidative stress. Results suggest that astaxanthin would compete with Nrf2 at the Keap1-DC domain, then promote Nrf2 induction and activate the antioxidant cellular machinery. These findings are supported by preliminary experimental evidence and highlight the potential of astaxanthin extracted from crustacean shell waste as a bioactive agent, with possible applications in diseases associated with oxidative stress, including cancer. Further preclinical and clinical in vivo studies are needed to validate astaxanthin and the carotenoprotein-astaxanthin complex for efficacy and safety, with potential relevance for oncology. - Source: PubMed
Publication date: 2026/06/15
Di Paola LuisaCaruso GabriellaManganiello FrancescaPlatania Chiara Bianca MariaAlbini AdrianaNoonan DouglasSerangeli Claudio - Hyperoside (HYP), a plant-derived flavonoid, was evaluated for its cytotoxic, anti-cancer, genotoxic, antigenotoxic, and antioxidant properties, and potential mechanisms of action using an integrated and approach. Cytotoxicity and anti-cancer activities were assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay in CCD18-Co healthy colon epithelial and DLD-1 colon cancer cells. At the same time, genotoxicity and antigenotoxicity potentials were examined in human lymphocytes using COMET assay. Antioxidant activity was determined by 2,2-Diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay, and molecular docking was performed with key regulatory proteins (p53, ATM, 7O7B, and Keap1), and toxicity profiling was conducted using the Percepta platform. HYP selectively reduced the viability of colon cancer cells (43.43% - 70.24%) without inducing cytotoxicity in healthy colon epithelial cells (cell viability percentage ranging from 82.25% - 111.88%) after 24 and 48 h of exposure. HYP did not significantly increase DNA damage at 7.81-62.5 μg/mL; however, it exhibited antigenotoxic effects at all concentrations, significantly reducing HO-induced DNA damage. HYP also showed significant antioxidant activity, with DPPH inhibition ranging from 53.09% to 78.64%. Docking analyses revealed strong binding affinities for ATM and Keap1, supporting its potential role in modulating oxidative stress and DNA damage response pathways. Percepta-based toxicity profiling predicted low to moderate acute systemic toxicity, limited oral bioavailability, and no major cardiotoxic or CYP-mediated safety liabilities; notably, predicted mutagenicity alerts were not corroborated by in vitro DNA damage assessments. Overall, these findings suggest that HYP exhibits selective anticancer and antigenotoxic properties, potentially mediated by its antioxidant activity. - Source: PubMed
Publication date: 2026/06/17
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