RPL19 antibody Polyclonal Antibodies Primary antibodies
- Known as:
- RPL19 (anti-) Polyclonal Antibodies Primary antibodies
- Catalog number:
- orb100548
- Product Quantity:
- 100
- Category:
- -
- Supplier:
- Biorb
- Gene target:
- RPL19 antibody Polyclonal Antibodies Primary antibodies
Related genes to: RPL19 antibody Polyclonal Antibodies Primary antibodies
- Gene:
- RPL19 NIH gene
- Name:
- ribosomal protein L19
- Previous symbol:
- -
- Synonyms:
- FLJ27452, MGC71997, DKFZp779D216, L19
- Chromosome:
- 17q12
- Locus Type:
- gene with protein product
- Date approved:
- 1991-11-29
- Date modifiied:
- 2019-04-23
Related products to: RPL19 antibody Polyclonal Antibodies Primary antibodies
Related articles to: RPL19 antibody Polyclonal Antibodies Primary antibodies
- Avian Influenza virus (AIV) and Newcastle disease virus (NDV) are highly contagious immunosuppressive pathogens that cause high mortality rates and economic losses in the global poultry industry. Although vaccination to enhance the host antibody response remains the main control strategy, the genetic basis of this variation is poorly understood. In this study, we used a genome-wide association study (GWAS) to investigate the genetic architecture of the longitudinal antibody responses to AIV (subtypes H5, H7, and H9) and NDV in chickens. - Source: PubMed
Publication date: 2026/08/11
Berihulay HaileLuo WeiLao AinongChuxiao LinJebessa EndashawZou XianJi JianQu HaoChen PengCai ManshanShu DingmingLuo Chenglong - Hematopoietic stem and progenitor cells (HSPCs) sustain lifelong blood production, yet the molecular mechanisms underlying their functional decline with age remain incompletely understood. Understanding how aging alters the transcriptomic landscape of HSPCs is critical to uncovering the origins of immune system aging. We performed a comprehensive single-cell RNA sequencing analysis integrating over 300,000 bone marrow-derived HSPCs from 50 healthy individuals spanning 19 to 84 years of age. Aging was associated with immune lineage skewing, marked by increased myeloid and decreased lymphoid output in both bone marrow and peripheral blood. Subtle increases in HSCs, MEPs, and myeloid progenitors alongside reductions in lymphoid progenitors were already evident in aged bone marrow, suggesting that lineage bias is encoded at the progenitor level. Age-associated transcriptional changes included extensive upregulation of ribosomal genes encoding small (RPS11, RPS12, RPS23) and large (RPL9, RPL19, RPL24) cytoplasmic ribosomal subunit proteins, as well as pro-inflammatory mediators (IL1B, IL18, TGFB1, S100A8). Enrichment analysis identified mitochondrial function, ribosome biogenesis, chromatin remodeling, and inflammatory signaling as key ontologies disrupted during HSPC aging. Our study identifies molecular signatures of systemic aging rooted in bone marrow HSPCs and suggests that dysregulated ribosomal protein gene expression is an under-appreciated hallmark of hematopoietic stem cell aging. - Source: PubMed
Atanga RogerMallik SauravSeth SoumitaGrodstein FrancineBennett David ALemos Bernardo - Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by amyloid-β deposition, tau pathology, and alterations in signaling pathways involved in neuronal survival and protein homeostasis. Lithium has been suggested as a potential neuroprotective treatment, but the molecular mechanisms associated with its long-term effects are still not fully understood. In this study, we investigated the effects of chronic lithium treatment on hippocampal proteins associated with PI3K-related signaling in triple-transgenic Alzheimer's disease (3xTg-AD) mice. Wild-type and transgenic animals received either a lower or higher lithium dose for eight months. Hippocampal samples were analyzed by LC-MS/MS proteomics followed by protein interaction and functional enrichment analyses. From a total of 7768 identified proteins, bioinformatic analyses identified 157 proteins shared between APP-, MAPT-, and PI3K-associated datasets. Further network analyses identified 18 proteins related to PI3K signaling, including seven proteins shared among all three datasets: FKBP1A, HSPA1B, HSPA8, RAS-related proteins, RPL13, RPL19, and RPL24. These proteins are associated with protein folding, translation regulation, cellular stress responses, and signaling pathways. Chronic lithium treatment was associated with changes in the expression of these proteins in both wild-type and transgenic animals. The observed effects differed between the two lithium concentrations tested and did not follow a simple linear pattern. Our findings suggest that long-term lithium exposure is associated with changes in molecular networks related to proteostasis and translational regulation in the hippocampus. Although additional studies are needed to better understand the mechanisms involved, these results provide a proteomic framework for investigating lithium-sensitive pathways that may be relevant to Alzheimer's disease. - Source: PubMed
Publication date: 2026/07/06
de Oliveira Portugal Couto CaíqueHass das Eiras Maria LuizaJuliao de Morais João LucasLeal Cordeiro Júnior Carlos WagnerForlenza Orestes Vicentede Jesus Rodrigues de Paula Vanessa - Ulcerative colitis (UC) is a chronic inflammatory disease of the gastrointestinal tract, characterized by immune dysregulation, genetic susceptibility, and environmental factors such as diet and psychosocial stress. The etiology of UC is complex, involving multiple interrelated factors that drive its pathogenesis and clinical progression. - Source: PubMed
Shi LihaoJin GuiyuanGao XizhuangChen YunZhao QianLin JianZhou Guangxi - This study aims to investigate the clinical efficacy and underlying mechanism of Huoxue Tongbi Formula in treating patients with steroid-induced osteonecrosis of the femoral head(SONFH) with meridian blockage syndrome. A total of 40 patients with SONFH and meridian blockage syndrome were retrospectively enrolled. Demographic data, clinical efficacy scores(pain and hip joint function), Harris scores, hip joint range of motion, imaging indices(ARCO stage, BUCMXE, bone marrow edema, and joint effusion), symptom/syndrome scores, and coagulation-related physiochemical indices(complete blood count, four coagulation tests, and four thrombosis tests) were collected and compared before treatment and after three months of treatment. Peripheral blood samples from three patients with significant efficacy were subjected to transcriptome sequencing before and after treatment to screen differentially expressed genes(DEGs). GO and KEGG enrichment and PPI network analysis were performed. Genes most relevant to the core phenotype of SONFH with meridian blockage syndrome were identified using Spearman correlation analysis. The results showed that Huoxue Tongbi Formula significantly improved the clinical efficacy scores(including pain and hip joint flexion function), Harris scores, and range of internal and external rotation of the hip(P<0.01). It also maintained stable imaging indices, alleviated various blood stasis-related clinical symptoms(hip pain, fixed pain, lower limb weakness)(P<0.05, P<0.001), and significantly reduced thrombin-antithrombin complex(TAT) levels(P<0.01). Transcriptome analysis identified 368 DEGs(274 upregulated and 94 downregulated). GO functional enrichment revealed that the biological processes involved by DEGs mainly include positive regulation of tumor necrosis factor production, integrin-mediated signaling pathways, neutrophil chemotaxis, and regulation of tumor necrosis factor production. KEGG enrichment analysis revealed that these DEGs were primarily involved in pathways such as hematopoietic cell lineage, osteoclast differentiation, complement and coagulation cascades, and platelet activation. PPI network analysis combined with correlation analysis identified core genes UBA52(r=0.83, P<0.05), RACK1(r=0.88, P<0.05), and RPL19(r=-0.87, P<0.05) were significantly correlated with blood stasis syndrome scores. CD74 was significantly correlated with osteonecrotic lesions(r=0.95, P<0.05) and TAT(r=0.88, P<0.05). These findings indicate that Huoxue Tongbi Formula ameliorates clinical symptoms and certain imaging indices in SONFH patients with meridian blockage syndrome by regulating hematopoiesis and bone metabolism(inhibiting osteoclast activity) and correcting hypercoagulability(inhibiting coagulation activation). Core genes such as UBA52, RACK1, and RPS3A may be key molecules linking blood stasis syndrome to the regulation of the coagulation-bone metabolism network. - Source: PubMed
Dong Peng-XuanMi Bao-HongLin NaZhang Yan-QiongChen Wei-Heng