ASAM antibody Polyclonal Antibodies Primary antibodies
- Known as:
- ASAM (anti-) Polyclonal Antibodies Primary antibodies
- Catalog number:
- orb100510
- Product Quantity:
- 100
- Category:
- -
- Supplier:
- Biorb
- Gene target:
- ASAM antibody Polyclonal Antibodies Primary antibodies
Related genes to: ASAM antibody Polyclonal Antibodies Primary antibodies
- Gene:
- CLMP NIH gene
- Name:
- CXADR like membrane protein
- Previous symbol:
- -
- Synonyms:
- ASAM, FLJ22415, ACAM
- Chromosome:
- 11q24.1
- Locus Type:
- gene with protein product
- Date approved:
- 2011-01-27
- Date modifiied:
- 2016-10-05
Related products to: ASAM antibody Polyclonal Antibodies Primary antibodies
Related articles to: ASAM antibody Polyclonal Antibodies Primary antibodies
- Grange syndrome is a rare early-onset multisystem disorder characterized by multifocal steno-occlusive arterial disease, bone fragility, congenital cardiac anomalies, skeletal manifestations, and intellectual disability, caused by biallelic loss-of-function variants in YY1AP1. We report eight affected individuals (six females, two males) from a single consanguineous family. Molecular analysis included exome sequencing in three patients (P1, P5, and P7) and targeted next-generation sequencing in one patient (P8), with Sanger sequencing performed for segregation analysis and parental carrier testing. A novel biallelic YY1AP1 variant (NM_001198903.1: c.2531_2532del; p.E844Gfs*34) was identified in all affected individuals. One patient, a 4-month-old female, harbored an additional novel biallelic pathogenic variant in CLMP (NM_024769.5: c.167dup; p.N56Kfs*2), consistent with a dual molecular diagnosis. The most common presenting feature was multiple fractures, observed in six patients. The mean age at first fracture was 3.6 ± 1.7 years, and the mean baseline bone mineral density (BMD) Z-score was -4.1 ± 1.6. Three patients received intravenous bisphosphonate therapy for at least 2 years, resulting in improvement of mean BMD Z-scores from -4.9 ± 1.9 to -2.4 ± 0.7. This study represents the first Grange syndrome cohort reported from Türkiye and expands the clinical spectrum by demonstrating marked phenotypic variability, multisystem involvement, and potential benefit of bisphosphonate therapy in patients with significant bone fragility. - Source: PubMed
Publication date: 2026/04/17
Akalın AkçahanÖz VeyselPınarbaşı Ayşe SedaÖzalkak ŞervanKaraca Mehmet SalihYıldırım Ruken - Herein, two Cu-(II) complexes of the type [Cu-(N-N)-(mftpy)]-(PF) (N-N = 4-chloro--(pyridin-2-methylene) aniline (Clmp) or 4-methyl--(pyridin-2-methylene) aniline (memp)-and mftpy = 4'-(4-methylphenyl)-2,2':6',2″-terpyridine) were successfully synthesized and characterized by microanalysis (% CHN), high-resolution mass spectrometry, Fourier-transform infrared spectroscopy, and ultraviolet-visible (solution and solid state) and electron paramagnetic resonance spectroscopies (solution and solid state). Next, the in vitro antibacterial activity of the [Cu-(Clmp)-(mftpy)]-(PF) and [Cu-(memp)-(mftpy)]-(PF) complexes was investigated in the planktonic and sessile form of and strains selected from a bank of strains characterized by resistance to first-line antibiotics. The quantification of planktonic cells showed a reduction that varied from 1.3 to 6.9 log CFU (colony forming units)/mL at a minimum inhibitory concentration of 25-400 μg/mL according to the tested strain. The biofilms suffered modification in their ultrastructure and showed evidence of the action of both complexes that surpassed the results with peracetic acid, with a reduction ≥2.6 log CFU/mL of sessile , with control of 1.2 orders of magnitude in the biomass formation by , and the highest penetration (4.92 μg) of into the biofilm. The results identified show that both complexes are biologically active, activating processes that allow the control of the pathogen in both lifestyles. - Source: PubMed
Publication date: 2026/01/23
Takeuchi Micaela GFerreira Ana Laura MRamos Luana M SPeixoto Jéssica Laura MChueiri Mariana CDumont Carolyne FFerreira Gabriella R Ade Jesus Diogo MRamos Thiago Dos SBogado André LPereira Gabriele de MPortes Marcelo CCorbi Pedro PFerreira Ana Maria da CRossi Daise AGuerra Wendellde Melo Roberta T - Physical activity (PA) and sedentary behavior (SB) are associated with many diseases, including Alzheimer's disease and all-cause dementia. However, the specific biological mechanisms through which PA protects against disease are not entirely understood. This study aims to address this gap, with a specific focus on all-cause dementia. - Source: PubMed
Publication date: 2026/01/26
Arani GayatriArora AmitYang ShuaiWu JingyueKraszewski Jennifer NMartins AmyMiller AlexandraZeba ZebunnesaJafri AyanHu ChengchengFarland Leslie VBea Jennifer WColetta Dawn KAslan Daniel HSayre M KatherineBharadwaj Pradyumna KAlly MadelineMaltagliati SilvioLai Mark H CWilcox Randde Geus EcoAlexander Gene ERaichlen David AKlimentidis Yann C - This study utilized a novel Proximity Barcoding Assay to perform high-resolution proteomic profiling of individual plasma extracellular vesicles from 85 patients with advanced high-grade serous ovarian carcinoma (OC) and 95 healthy controls (HC). Single-EV analysis identified 119 differentially expressed proteins and 17 distinct EV subpopulations. Cluster 7 (enriched in integrins ITGB3, ITGB1, and ITGA6) was significantly elevated in OC plasma (4.47% in HC vs. 14.79-15.82% in OC). Machine learning (SVM-RFE, LASSO, Random Forest) identified a diagnostic panel (ITGA6, ITGB2, ILK) achieving exceptional accuracy in distinguishing OC from HC (AUC = 0.999 training; 1.000 validation). Furthermore, risk models incorporating specific protein signatures effectively stratified patients by platinum sensitivity/resistance (9-protein panel: ILK, CDCP1, CD86, CLDN4, CLEC1B, CDHR5, CLDN11, JAM2, FOLH1), lymph node metastasis status (7-protein panel: APOE, CD28, CLDN4, FOLH1, ITGAL, JAML, ULBP3), and post-surgical residual disease burden (4-protein panel: CD44, CLMP, ITGA4, AMIGO1), with Cluster 13 (ITGB1-high) also significantly associated with residual disease. This work demonstrates the power of single-EV proteomics combined with machine learning for non-invasive diagnosis and clinical outcome assessment in advanced ovarian cancer, though the absence of early-stage patients limits its applicability for early detection. - Source: PubMed
Publication date: 2026/01/21
Wu BeierYang XupingCai YanlingWan ShihanLiu JingfangXing JieChen XinZhang JiejieJin YanluYu AijunYang Li - In this study, four novel Cu-(II) complexes of the type [Cu-(imine)-(b-diketone)-(NO)], namely, [Cu-(clmp)-(bta)-(NO)]·HO , [Cu-(clmp)-(btacl)-(NO)] , [Cu-(memp)-(bta)-(NO)]·HO , and [Cu-(memp)-(btacl)-(NO)]·HO , in which clmp = 4-chloro--(pyridin-2-methylene) aniline, memp = 4-methyl--(pyridin-2-methylene) aniline, bta = (4,4,4-trifluoro-1-phenyl-1,3-butanedionate, and btacl = 1-(4-chlorophenyl)-4,4,4-trifluoro-1,3-butanedionate), were prepared and characterized by elemental analysis, mass spectrometry, conductivity measurements, FT-IR, UV-vis, and single-crystal X-ray diffraction. The spectral and structural data confirmed that the β-diketone anions coordinate to Cu-(II) via the oxygen atoms, while the imine ligands coordinate by the nitrogen atoms. A weakly coordinated nitrate completes the coordination sphere around the metal center. Subsequently, experiments were conducted in MDA-MB231 triple-negative breast cancer cells (TNBC) in which MTT, SRB, LDH, clonogenicity, migration, and caspase activity analyses were performed. lncRNAs associated with epithelial-mesenchymal transition (EMT) were also quantified by qPCR. In the MTT assay, complexes and exhibited IC values below 20 μM and greater selectivity toward the nontumorigenic MCF-10A cells. The SRB and LDH assays also demonstrated reduced cell viability and increased lactate dehydrogenase release mediated by both complexes. Clonogenicity and migration of TNBC cells were also reduced by and , and an increase in the activity of caspases 3 and 8 was observed, with the most pronounced effects recorded for . Finally, the expression of lncRNAs was downregulated by and , demonstrating the role of the complexes in the modulation of EMT. These findings highlight complexes and as potential antitumor agents for TNBC, emphasizing the importance of exploring the intrinsic mechanisms underlying their anticancer activity. - Source: PubMed
Publication date: 2025/12/19
Rocha Gislaine GonçalvesRamos Luana Munique SousaBarbosa Laryssa Aparecida SalesSiqueira Raoni Paisda Silva Fernanda CardosoBrandão Douglas CardosoLima Paula Marynella Alves Pereirade Matos André Carlos PereiraBogado André LuizGuedes Guilherme PereiraResende Jackson Antonio Lamounier CamargoPereira Gabriele de MenezesCorbi Pedro PauloGuerra Wendellde Araújo Thaise Gonçalves