ADAM20 antibody Polyclonal Antibodies Primary antibodies
- Known as:
- ADAM20 (anti-) Polyclonal Antibodies Primary antibodies
- Catalog number:
- orb100492
- Product Quantity:
- 100
- Category:
- -
- Supplier:
- Biorb
- Gene target:
- ADAM20 antibody Polyclonal Antibodies Primary antibodies
Related genes to: ADAM20 antibody Polyclonal Antibodies Primary antibodies
- Gene:
- ADAM20 NIH gene
- Name:
- ADAM metallopeptidase domain 20
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 14q24.2
- Locus Type:
- gene with protein product
- Date approved:
- 1998-12-01
- Date modifiied:
- 2015-09-10
Related products to: ADAM20 antibody Polyclonal Antibodies Primary antibodies
Related articles to: ADAM20 antibody Polyclonal Antibodies Primary antibodies
- Genetic variants and epigenetic features both contribute to the risk of Alzheimer's disease (AD). We studied the AD association of CpG-related single nucleotide polymorphisms (CGS), which act as a hub of both the genetic and epigenetic effects, in Caribbean Hispanics (CH) and generalized the findings to Non-Hispanic Whites (NHW). First, we conducted a genome-wide, sliding-window-based association with AD, in 7,155 CH and 1,283 NHW participants. Next, using data from the dorsolateral prefrontal cortex in 179 CH brains, we tested the cis- and trans-effects of AD-associated CGS on brain DNA methylation to mRNA expression. For the genes with significant cis- and trans-effects, we investigated their enriched pathways. We identified six genetic loci in CH with CGS dosage associated with AD at genome-wide significance levels: ADAM20 (Score = 55.19, P = 4.06 × 10), the intergenic region between VRTN and SYNDIG1L (Score = - 37.67, P = 2.25 × 10), SPG7 (16q24.3) (Score = 40.51, P = 2.23 × 10), PVRL2 (Score = 125.86, P = 1.64 × 10), TOMM40 (Score = - 18.58, P = 4.61 × 10), and APOE (Score = 75.12, P = 7.26 × 10). CGSes in PVRL2 and APOE were also significant in NHW. Except for ADAM20, CGSes in the other five loci were associated with CH brain methylation levels (mQTLs) and CGSes in SPG7, PVRL2, and APOE were also mQTLs in NHW. Except for SYNDIG1L (P = 0.08), brain methylation levels in the other five loci affected downstream mRNA expression in CH (P < 0.05), and methylation at VRTN and TOMM40 were also associated with mRNA expression in NHW. Gene expression in these six loci were also regulated by CpG sites in genes that were enriched in the neuron projection and glutamatergic synapse pathways (FDR < 0.05). DNA methylation at all six loci and mRNA expression of SYNDIG1 and TOMM40 were significantly associated with Braak Stage in CH. In summary, we identified six CpG-related genetic loci associated with AD in CH, harboring both genetic and epigenetic risks. However, their downstream effects on mRNA expression maybe ethnic specific and different from NHW. - Source: PubMed
Publication date: 2024/08/23
Ma YiyiReyes-Dumeyer DollyPiriz AngelRecio PatriciaMejia Diones RiveraMedrano MartinLantigua Rafael AVonsattel Jean Paul GTosto GiuseppeTeich Andrew FCiener BenjaminLeskinen SandraSivakumar SharanyaDeTure MichaelRanjan DuaraDickson DennisMurray MelissaLee EdwardWolk David AJin Lee-WayDugger Brittany NHiniker AnnieRissman Robert AMayeux RichardVardarajan Badri N - The Icelandic horse and Exmoor pony are ancient, native breeds, adapted to harsh environmental conditions and they have both undergone severe historic bottlenecks. However, in modern days, the selection pressures on these breeds differ substantially. The aim of this study was to assess genetic diversity in both breeds through expected (H) and observed heterozygosity (H) and effective population size (Ne). Furthermore, we aimed to identify runs of homozygosity (ROH) to estimate and compare genomic inbreeding and signatures of selection in the breeds. - Source: PubMed
Publication date: 2024/08/08
Sigurðardóttir HeiðrúnAblondi MichelaKristjansson ThorvaldurLindgren GabriellaEriksson Susanne - Since the advent of gene-targeting technology in embryonic stem cells, mice have become a primary model organism for investigating human gene function due to the striking genomic similarities between the two species. With the introduction of the CRISPR/Cas9 system for genome editing in mice, the pace of loss-of-function analysis has accelerated significantly. This has led to the identification of numerous genes that play crucial roles in male reproductive processes, including meiosis, chromatin condensation, flagellum formation in the testis, sperm maturation in the epididymis, and fertilization in the oviduct. Despite the advancements, the functions of many genes, particularly those enriched in male reproductive tissues, remain largely unknown. In our study, we focused on 15 genes and generated 13 gene-deficient mice [, triple (, , and ), , , , , , , , , , , and ] to elucidate their roles in male fertility. Surprisingly, all 13 gene-deficient mice exhibited normal fertility in natural breeding experiments, indicating that these genes are not essential for male fertility. These findings have important implications as they may help prevent other research laboratories from duplicating efforts to generate knockout mice for genes that do not demonstrate an apparent phenotype related to male fertility. By shedding light on the dispensability of these genes, our study contributes to a more efficient allocation of research resources in the exploration of male reproductive biology. - Source: PubMed
Publication date: 2024/05/21
Nguyen Tuyen Thi ThanhTokuhiro KeizoShimada KeisukeWang HaotingMashiko DaisukeTonai ShingoKiyozumi DaijiIkawa Masahito - Both genetic variants and epigenetic features contribute to the risk of Alzheimer's disease (AD). We studied the AD association of CpG-related single nucleotide polymorphisms (CGS), which act as the hub of both the genetic and epigenetic effects, in Hispanics decedents and generalized the findings to Non-Hispanic Whites (NHW) decedents. - Source: PubMed
Publication date: 2024/02/14
Ma YiyiReyes-Dumeyer DollyPiriz AngelRecio PatriciaMejia Diones RiveraMedrano MartinLantigua Rafael AVonsattel Jean Paul GTosto GiuseppeTeich Andrew FCiener BenjaminLeskinen SandraSivakumar SharanyaDeTure MichaelRanjan DuaraDickson DennisMurray MelissaLee EdwardWolk David AJin Lee-WayDugger Brittany NHiniker AnnieRissman Robert AMayeux RichardVardarajan Badri N - High myopia (HM), an eye disorder with at least -6.0 diopters refractive error, has a complex etiology with environmental, genetic, and likely epigenetic factors involved. To complement the DNA methylation assessment in children with HM, we analyzed genes that had significantly lower DNA methylation levels. - Source: PubMed
Swierkowska JoannaKarolak Justyna AVishweswaraiah SangeethaMrugacz MalgorzataRadhakrishna UppalaGajecka Marzena