POC5 antibody Polyclonal Antibodies Primary antibodies
- Known as:
- POC5 (anti-) Polyclonal Antibodies Primary antibodies
- Catalog number:
- orb100447
- Product Quantity:
- 100
- Category:
- -
- Supplier:
- Biorb
- Gene target:
- POC5 antibody Polyclonal Antibodies Primary antibodies
Related genes to: POC5 antibody Polyclonal Antibodies Primary antibodies
- Gene:
- POC5 NIH gene
- Name:
- POC5 centriolar protein
- Previous symbol:
- C5orf37
- Synonyms:
- FLJ35779, MGC120442, MGC120443, MGC120444, hPOC5
- Chromosome:
- 5q13.3
- Locus Type:
- gene with protein product
- Date approved:
- 2007-02-06
- Date modifiied:
- 2013-08-05
Related products to: POC5 antibody Polyclonal Antibodies Primary antibodies
Related articles to: POC5 antibody Polyclonal Antibodies Primary antibodies
- This study investigated the antifungal performance of copper-based antimicrobial coatings developed by Gencoa Ltd., previously validated against bacterial ESKAPE pathogens, alongside newly formulated titanium oxide coatings, against key agricultural fungal pathogens: Alternaria alternata, Botrytis cinerea, Cladosporium cucumerinum, and Fusarium oxysporum. Testing was conducted both in vitro and in field trials within an actively used polytunnel. - Source: PubMed
Kubala AntonKillen PatriciaBoyle OisinBellido-Gonzalez VíctorSgrilli TommasoMcLean Samantha - Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related mortality worldwide. This study aimed to identify key genes involved in HCC development and elucidate their molecular mechanisms, with a particular focus on mitochondrial function and apoptosis. - Source: PubMed
Publication date: 2025/12/30
Shi HuihuiChen LeiHuang JuanLin XuejingHuang LeiTang MinLu KaiWang WenchaoZhu Maoling - Centrioles undergo marked transformations during spermatogenesis that are essential for sperm motility and male fertility. Despite their importance, the molecular mechanisms and ultrastructural dynamics underlying these transformations remain largely unknown. Here, we apply ultrastructure expansion microscopy and reveal previously unrecognized centriolar architectural changes in mouse male germ cells, including geometry switching between the two centrioles and stage-specific removal of distal tip proteins such as centrin and SFI1. We further identify the centrin-POC5 inner scaffold as a key structure selectively augmented at the distal centriole, which directly forms and anchors the flagellum. Functional analyses of knockout mice demonstrate that this inner scaffold is essential for distal centriole integrity and flagellar assembly in spermatids but dispensable in somatic cells and spermatocytes. Our findings provide a spatiotemporal molecular atlas of centriole remodeling during spermatogenesis and uncover the critical physiological role of the centriolar centrin-POC5 inner scaffold in mammalian reproduction. - Source: PubMed
Publication date: 2025/12/03
Takeda YutakaKajikawa ErikoWang JingwenIshida MoriéAlsheimer ManfredShibuya Hiroki - The study examined the association between body composition and beverage consumption and the risk of asthma and chronic obstructive pulmonary disease (COPD) and explored the single nucleotide polymorphisms (SNPs) involved in these associations by leveraging summary statistics from genome-wide association studies (GWAS) in nonoverlapping populations. The IEU OpenGWAS project was sourced for exposure datasets: body mass index, body fat percentage, fat-free mass, total body water mass, alcohol intake frequency, and coffee intake, and selected health outcome datasets: asthma and chronic obstructive pulmonary disease. Datasets were assessed and filtered using R, followed by a two-sample Mendelian randomization analysis. The MR Egger, weighted median, inverse variance weighted, simple mode, and weighted mode methods were used to examine the association between exposures and outcomes. Heterogeneity and pleiotropy analyses were used to evaluate the reliability of results. Additionally, SNPnexus was used to ascertain SNPs linked to established phenotypes, while SNP annotation was obtained from the Ensembl BioMart database via the biomaRt package. Genes belonging to overlapping groups were visualized using ComplexHeatmap. Higher body fat percentage (OR = 1.72, 95% CI: 1.23-2.41, = 0.002), increased BMI (OR = 1.56, CI: 1.23-1.20, = 2.53 × 10), and more frequent alcohol intake (OR = 1.34, CI: 1.08-1.68, = 0.009) were associated with elevated COPD risk. Asthma risk was similarly increased with higher body fat percentage (OR = 1.60, CI: 1.23-2.21, = 0.001), BMI (OR = 1.54, CI: 1.29-1.84, = 2.23 × 10), fat-free mass (OR = 1.21, CI: 1.02-1.44, = 0.032), and alcohol intake frequency (OR = 1.19, CI: 1.01-1.40, = 0.039). Total body water mass and coffee intake were not associated with asthma and COPD. SNP annotation revealed that some genetic variants that influenced the association of the exposure variables with asthma and COPD were missense variants in several genes, including the evolutionarily highly conserved gene, (rs13107325; C/A/T allele), and (rs2307111; T/A/C allele), as well as intronic variants in (rs56094641; A/G/T allele) and (rs10146997; A/G allele). The discovery of the missense variants rs13107325 and rs2307111 in and , respectively, in addition to other intronic and synonymous SNPs suggests that these SNPs may have some roles in the development or progression of asthma and COPD. This may contribute to the identification of molecular signatures or biomarkers that forecast the risk, development, or therapeutic response of chronic lung diseases in persons with metabolic dysregulation, including obesity. - Source: PubMed
Publication date: 2025/08/12
Apalowo Oladayo EWalt Hunter KAlaba Tolu EKomakech Joel JSchilling Mark W - A homozygous loss-of-function (LoF) variant in POC5 was previously described in an individual with retinitis pigmentosa. We identified POC5 variants in 12 probands with a syndromic phenotype. We aim to define the phenotype spectrum and molecular mechanism associated with biallelic POC5 LoF variants. - Source: PubMed
Publication date: 2025/06/28
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