STAT4 Antibody;mouse, rat
- Known as:
- STAT4 Antibody;mouse, rat
- Catalog number:
- ASAKAP-TF004C
- Product Quantity:
- 25 µg
- Category:
- -
- Supplier:
- Other suppliers
- Gene target:
- STAT4 Antibody;mouse rat
Related genes to: STAT4 Antibody;mouse, rat
- Gene:
- STAT4 NIH gene
- Name:
- signal transducer and activator of transcription 4
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 2q32.2-q32.3
- Locus Type:
- gene with protein product
- Date approved:
- 1995-11-08
- Date modifiied:
- 2018-02-13
Related products to: STAT4 Antibody;mouse, rat
Related articles to: STAT4 Antibody;mouse, rat
- 2,2',4,4'-Tetrabromodiphenyl ether (BDE-47) is ubiquitously present in diverse water environments and aquaculture water bodies. A growing body of studies have revealed that BDE-47 has the potential to pose hazards to a broad range of organisms, but its toxicological mechanisms are still unclear. In the study, biotoxic effects and mechanisms of BDE-47 dietary exposure to carp liver were investigated. Data from the present study found that BDE-47 dietary expose increased AST and ALT activities in carp plasma, indicating impaired liver function. Transmission electron microscopy showed that the cell structure in the High group was damaged, suggesting that cell death is the cause of liver impairment. LDH content determination and comet experiments further verified the DNA damage caused by BDE-47 in hepatocytes, indicating that it may lead to programmed cell death. Combining transcriptome analysis and immunofluorescence analysis, it was found that BDE-47 induced necroptosis in carp liver. Docking suggested strong binding affinity of BDE-47 for STAT4. qPCR and WB analysis showed that BDE-47 treatment significantly increased the gene and protein expression levels of STAT4, RIPK1, and MLKL, showing that BDE-47 provoked necroptosis in carp liver through the JAK3/STAT4 pathway. On the whole, this study revealed that dietary exposure to BDE-47 induces liver impairment and necroptosis in carp liver through the JAK3/STAT4 pathway. This result not only provides new molecular targets for further elucidating the toxic mechanisms of PBDE contaminants in aquatic organisms, but also offers evidence for assessing the ecological risks of such pollutants and safeguarding the health of aquatic ecosystems. - Source: PubMed
Publication date: 2026/06/04
Yuan MengbinHan NianChen ShuhuangLi ChangyuanLi ShiqiTian BuwenTang NiZhou BoDu XueChen DefangLi ZhiqiongZhang Xin - Rheumatoid arthritis (RA) is a complex autoimmune disease with a strong genetic component. The STAT4 rs7574865 (G>T) variant has been associated with RA in various populations, but data from North Africa remain limited. This study aimed to investigate the association of rs7574865 with RA susceptibility in Moroccan patients. - Source: PubMed
Publication date: 2026/05/21
Alami OumaimaMissoum HakimaAlami MohammedBimouhen AbderrahmanToufik HamzaEl Maghraoui AbdellahBakri YoussefAdadi Najlae - : The STAT (Signal Transducer and Activator of Transcription) family of seven transcription factors mediates cytokine and growth-factor signaling, regulating proliferation, differentiation, and immunity. While STAT3/STAT5 are established oncogenes and STAT1/STAT2 are classically viewed as tumor suppressors, emerging evidence indicates context-dependent roles in tumorigenesis. This study aimed to integrate evolutionary analysis with bulk transcriptomic, regulon, single-cell, and exploratory chromatin-binding analyses of the STAT family in human solid tumors. : Orthologs and paralogs of human STAT genes (81 sequences total) were retrieved across vertebrates and invertebrates; a phylogenetic tree was constructed using MUSCLE alignment and Neighbor-Joining in MEGA12. Differential expression was assessed in TCGA solid tumors versus GTEx normal tissues. Master-regulator activity was inferred using the algorithm. Single-cell RNA-seq datasets were used to compare malignant and non-malignant cell populations. STAT1 chromatin binding was examined via ChIP-seq in interferon-stimulated HeLa and K562 cells. : Phylogeny resolved seven conserved vertebrate clades, with endocrine-responsive STAT3/STAT5 showing higher conservation and immune-associated STAT1/STAT2/STAT4/STAT6 exhibiting faster divergence. The majority of STAT genes were frequently upregulated across multiple solid tumors, with activated regulons confirming functional transcriptional engagement. Single-cell analysis demonstrated tumor-cell-autonomous upregulation of STAT1 and STAT2 in the HNSCC dataset. STAT1 ChIP-seq revealed asymmetric forward/reverse-strand read density around peak summits, supporting non-canonical DNA recognition. : The STAT family operates as an evolutionarily conserved, broadly activated transcriptional module in human solid cancers, combining quantitative upregulation with qualitative shifts in DNA-binding dynamics. These findings refine our understanding of JAK/STAT signaling in oncology and highlight opportunities for network-targeted therapies. - Source: PubMed
Publication date: 2026/05/03
Lukic DunjaGuzzi Pietro HiramGiorgi Federico Manuel - Mendelian susceptibility to mycobacterial disease (MSMD) is a rare syndrome characterized by increased and selective susceptibility to weakly virulent mycobacteria and other intramacrophagic pathogens. This study emphasizes the utility of immunological and functional assays in diagnosing MSMD by analyzing clinical, immunological, and genetic features in 50 Indian patients. Immunological workup included lymphocyte subset analysis, nitroblue tetrazolium test (NBT), and flow cytometric assessment of IFN-γR1 (CD119), IL-12Rβ1 (CD212), and phosphorylated STAT1/STAT4 following cytokine stimulation. Functional assays measured IFN-γ and IL-12p70 production. Genetic evaluation was performed using whole-exome or Sanger sequencing. The median age at onset was 3 mo. BCG complications were the most common presentation (96%), while 4% had non-tuberculous mycobacterial infections. Additional infections included , spp., spp., and multiple types of viruses. IL-12Rβ1 deficiency was the most frequent diagnosis, with 10 novel variants in the gene identified. These results demonstrate that combining flow cytometry with functional and genetic analyses enables accurate and timely MSMD diagnosis. - Source: PubMed
Publication date: 2025/12/18
Dalvi AparnaTemkar LavinaDesai MukeshGarg SwatiAluri JahnaviHule GouriBargir Umair AhmedSetia PriyankaKambli PriyankaDhawale AmrutaTamhankar ParagYadav Reetika MalikBhattad SagarSivasankaran MeenaLashkari Harsha PrasadKacha AsrutiBharathi T KasiKanakia SwatiGandhi Kamana ArunShelar ShraddhaShinde ShwetaJodhawat NehaKawale RameshSalve NitinCasanova Jean-LaurentBustamante JacintaMadkaikar Manisha R - Primary Biliary Cholangitis (PBC) frequently coexists with various autoimmune diseases, such as Multiple Sclerosis (MS), Psoriasis (PS), Rheumatoid Arthritis (RA), and Sjögren's Syndrome (SS). Understanding the genetic associations between these diseases is crucial for providing deeper insights into their shared pathogenic mechanisms and comorbidity patterns. - Source: PubMed
Publication date: 2026/05/17
Shang ChaoBai YuanyuanZhao Yong