CKS2 antibody Polyclonal Antibodies Primary antibodies
- Known as:
- CKS2 (anti-) Polyclonal Antibodies Primary antibodies
- Catalog number:
- orb100246
- Product Quantity:
- 100
- Category:
- -
- Supplier:
- Biorb
- Gene target:
- CKS2 antibody Polyclonal Antibodies Primary antibodies
Related genes to: CKS2 antibody Polyclonal Antibodies Primary antibodies
- Gene:
- CKS2 NIH gene
- Name:
- CDC28 protein kinase regulatory subunit 2
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 9q22.2
- Locus Type:
- gene with protein product
- Date approved:
- 1996-03-12
- Date modifiied:
- 2016-10-05
Related products to: CKS2 antibody Polyclonal Antibodies Primary antibodies
Related articles to: CKS2 antibody Polyclonal Antibodies Primary antibodies
- Recurrence-free survival (RFS) following radical prostatectomy is a pivotal measure of therapeutic success in prostate cancer (PCa), yet conventional clinicopathological tools offer limited discriminative accuracy. We sought to construct a platform-independent prognostic signature to predict RFS by capturing early molecular traces of advanced disease potential. - Source: PubMed
Publication date: 2026/07/31
He YuLi BoyangTan ZhaojieJiang KuanyaoJu WenyueYu WeidongZhang MengLiang Chaozhao - We hypothesized that acute respiratory distress syndrome (ARDS) and sepsis share hypoxia-related transcriptional signatures that reflect overlapping immunopathogenic mechanisms. This study aimed to identify shared hypoxia-related genes and associated regulatory features using bioinformatic analyses. Gene expression datasets GSE28750 and GSE76293 were analyzed separately after within-dataset normalization. Differentially expressed genes (DEGs) were defined using |logFC| > 1 and adjusted P < .05. Hypoxia-related genes were compiled from GeneCards, PubMed-curated studies, and molecular signatures database, harmonized by official gene symbols, and intersected with common DEGs from both datasets to identify hypoxia-related DEGs (HRDEGs). Gene ontology enrichment, gene set enrichment analysis, interaction network analysis, immune infiltration analysis, and protein-protein interaction analysis using STRING with a minimum interaction score of 0.400 were subsequently performed. Eleven HRDEGs were identified: capping actin protein, gelsolin-like, CKS2, CLU, FLVCR1, FUNDC1, HPSE, LCN2, MAPK14, PFKFB3, PLAC8, and TDRD9. Gene ontology enrichment suggested involvement in cellular iron ion homeostasis- and iron ion transport-related processes. Gene set enrichment analysisindicated enrichment of hypoxia- and inflammation-related pathways. Under the stricter STRING threshold (score ≥ 0.400), the protein-protein interaction network showed a limited but biologically plausible interaction pattern among the HRDEGs. Predicted miRNA, ribonucleic acid-binding protein, transcription factor, drug, and immune infiltration analyses further suggested that these genes may participate in inflammatory and immune regulatory processes relevant to ARDS and sepsis. This bioinformatic study identified shared hypoxia-associated genes in ARDS and sepsis and generated testable hypotheses regarding their possible regulatory and immunologic relevance. These findings should be interpreted as exploratory and warrant experimental validation in future studies. - Source: PubMed
Zhang RuiFu YinghuaLong FangCheng Qiong - Psoriasis represents a prevalent long-term inflammatory skin condition marked by the dysregulation of immune responses. T cells are integral to the pathogenesis of psoriasis. This study conducted a comprehensive analysis to recognize biomarkers associated with T cell infiltration in psoriasis and to elucidate their underlying molecular mechanisms. - Source: PubMed
Publication date: 2026/07/04
Zhang LiYang Xiao-YanLi Fa-ZengLiu Zhi-QuanZhang LeiOu Zheng-Fa - Spermatogonial differentiation is a key step in spermatogenesis, yet the transcriptional programs that control this process are not fully defined. E4f1 has been reported to be essential for embryonic development, mitochondrial function and spermatogonial stem cell (SSC) maintenance in mice. However, its function in spermatogonial differentiation and meiosis progression is unknown. - Source: PubMed
Publication date: 2026/04/14
Wang Fei-ChenHe ZhenYan Rong-GeWang Yu-JunWu Jia-LuYang Qi-En - Mushrooms are highly valued as sources of novel bioactive molecules with therapeutic relevance. This study explored the potential of methanolic extract of (Sowerby) Imazeki using a combination of phytochemical, computational, and experimental approaches to evaluate its antidiabetic and anticancer activities. GC-MS analysis revealed a sterol-dominant profile, with ergosterol, ergosta-5,7-dien-3β-ol, α-ergostenol, and 9,11-dehydroprogesterone identified as the major metabolites. In silico study confirmed drug-likeness properties of compounds, while absorption, distribution, metabolism, excretion, and toxicity (ADMET) predictions suggested good gastrointestinal absorption, negligible mutagenicity, and low carcinogenic risk, though limited biodegradability was observed. Molecular docking revealed strong interactions of sterol derivatives (- 9.0 to - 10.2 kcal/mol) with diabetes-related (α-amylase) and cancer-associated (Aurora-A, CDK1/Cks2, PLK1) targets. In vitro validation confirmed significant α-amylase inhibitory activity, with an IC value of 0.85 ± 0.09 mg/mL.The methanolic extract exhibited notable cytotoxic activity against 4T1 breast cancer cells, showing 71.28% growth inhibition at 1500 µg/mL, with an IC value of 721 ± 6 µg/mL. Overall, contains valuable sterol-based compounds with dual therapeutic potential against diabetes and cancer, which signify this mushroom as a potential lead for natural drug development. - Source: PubMed
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