IFNA17 antibody Polyclonal Antibodies Primary antibodies
- Known as:
- IFNA17 (anti-) Polyclonal Antibodies Primary antibodies
- Catalog number:
- orb100182
- Product Quantity:
- 100
- Category:
- -
- Supplier:
- Biorb
- Gene target:
- IFNA17 antibody Polyclonal Antibodies Primary antibodies
Related genes to: IFNA17 antibody Polyclonal Antibodies Primary antibodies
- Gene:
- IFNA17 NIH gene
- Name:
- interferon alpha 17
- Previous symbol:
- -
- Synonyms:
- LEIF2C1, IFN-alphaI
- Chromosome:
- 9p21.3
- Locus Type:
- gene with protein product
- Date approved:
- 1993-01-14
- Date modifiied:
- 2016-10-05
Related products to: IFNA17 antibody Polyclonal Antibodies Primary antibodies
Related articles to: IFNA17 antibody Polyclonal Antibodies Primary antibodies
- The incidence of esophageal squamous cell carcinoma (ESCC) is increasing globally. Notably, in Xinjiang, China, ESCC patients have garnered significant attention due to their unique epidemiological characteristics. Specifically, the mortality rate of Xinjiang Kazakh ESCC (referred to as XK ESCC) is substantially higher than the national average in China. This alarming disparity underscores the critical need for identifying new therapeutic targets. In this study, we aimed to elucidate the underlying genomic abnormalities in XK ESCC by conducting whole-exome sequencing on four matched pairs of esophageal squamous cell tumors and adjacent control tissues from Xinjiang Kazakh individuals. Comprehensive statistical analysis of the exome data revealed multiple somatic mutations, copy number variations (CNVs), and 14 potential cancer driver genes harbouring missense mutations. Additionally, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) functional enrichment analyses were performed on 75 significantly mutated genes (SMGs). Intriguingly, we identified IFNA17 and NLRP6 as significantly mutated genes enriched in the NOD-like receptor signaling pathway. Subsequent functional studies on ESCC-derived IFNA17 and NLRP6 mutants demonstrated that these mutations enhance cellular invasion. To the best of our knowledge, this study represents the first comprehensive exome sequencing analysis specifically targeting XK ESCC. Our findings highlight novel mutation loci that may explain the aggressive nature of XK ESCC. These insights could contribute to the development of early diagnostic and prognostic markers, as well as therapeutic targets, tailored for XK ESCC. - Source: PubMed
Publication date: 2025/07/12
Wang Meng-BoYang Li-LiChen Hai-XiaLv Hong-BoLiang Li-PingMa Xiao-MeiWang QianGao Hai-Xia - Ductal carcinoma in situ (DCIS) is a non-obligate precursor of invasive breast cancer with highly variable clinical behavior, but risk stratification is still challenging. We sought to identify immune-related gene expression signatures of pure DCIS associated with different risks of breast cancer recurrence. - Source: PubMed
Publication date: 2024/04/12
Guerini-Rocco ElenaBellerba FedericaConcardi AlbertoTaormina Sergio VincenzoCammarata GiulioFumagalli CaterinaGuerrieri-Gonzaga AlianaMacis DeboraDel Fiol Manna ElizaBalladore EmanuelaCannone MariaVeronesi PaoloFusco NicolaBonanni BernardoViale GiuseppeBarberis MassimoGandini SaraLazzeroni Matteo - The influence of a single H/H replacement on the frequency generation of different-size bubbles in the human interferon alpha-17 gene (IFNA17) under various energies was studied by a developed algorithm and mathematical modeling without simplifications or averaging. This new approach showed the efficacy of researching DNA bubbles and open states both when all hydrogen bonds in nitrogenous base pairs are protium and after an H-substitution. After a single deuterium substitution under specific energies, it was demonstrated that the non-coding region of IFNA17 had a more significant regulatory role in bubble generation in the whole gene than the promoter had. It was revealed that a single deuterium substitution for protium has an influence on the frequency generation of DNA bubbles, which also depends on their size and is always higher for the smaller bubbles under the largest number of the studied energies. Wherein, compared to the natural condition under the same critical value of energy, the bigger raises of the bubble frequency occurrence (maximums) were found for 11-30 base pair (bp) bubbles (higher by 319%), 2-4 bp bubbles (higher by 300%), and 31 bp and over ones (higher by 220%); whereas the most significant reductions of the indicators (minimums) were observed for 11-30 bp bubbles (lower by 43%) and bubbles size over 30 bp (lower by 82%). In this study, we also analyzed the impact of several circumstances on the AT/GC ratio in the formation of DNA bubbles, both under natural conditions and after a single hydrogen isotope exchange. Moreover, based on the obtained data, substantial positive and inverse correlations were revealed between the AT/GC ratio and some factors (energy values, size of DNA bubbles). So, this modeling and variant of the modified algorithm, adapted for researching DNA bubbles, can be useful to study the regulation of replication and transcription in the genes under different isotopic substitutions in the nucleobases. - Source: PubMed
Publication date: 2023/07/28
Basov AlexandrDorohova AnnaMalyshko VadimMoiseev ArkadiiSvidlov AlexandrBezhenar MariaNechipurenko YuryDzhimak Stepan - In systemic lupus erythematosus (SLE), the relevance of non-hematopoietic sources of type I interferon in human autoimmunity has recently been recognized. Particularly, type I interferon production precedes autoimmunity in early skin lesions related to SLE. However, the relevance of intrarenal type I interferon expression has not been shown in lupus nephritis. From transcriptome array datasets, median-centered log mRNA expression levels of IFNα (, , , , , , , , , , , , and ), IFNω (), and IFNβ () in lupus nephritis were extracted specifically from microdissected tubulointerstitial ( = 32) and glomerular compartments ( = 32). We found an association between proteinuria and tubulointerstitial expression of type I interferon ( = 0.0142), while all others were not significantly associated. By contrast, no such correlation was observed between proteinuria and any type I interferon expression in the glomerular compartment in lupus nephritis. Interestingly, there was no difference between female and male patients ( = 0.8237) and no association between type I interferon expression and kidney function or lupus nephritis progression. Finally, we identified distinct molecular signatures involved in transcriptional regulation (GLI protein-regulated transcription, IRF7 activation, and HSF1-dependent transactivation) and receptor signaling (BMP signaling and GPCR ligand binding) in association with tubulointerstitial expression of type I interferon in the kidney. In summary, this transcriptome array-based approach links proteinuria to the tubulointerstitial expression of type I interferon in lupus nephritis. Because type I interferon receptor subunit I antagonism has recently been investigated in active SLE, the current study further emphasizes the role of type I interferons in lupus nephritis and might also be of relevance for mechanistic studies. - Source: PubMed
Publication date: 2023/06/25
Korsten PeterTampe Björn - Diffuse large B-cell lymphoma (DLBCL) shows a high degree of clinical and biological heterogeneity. Primary testicular lymphoma (PTL) is an extranodal variant of DLBCL associated with a higher risk of recurrence, including contralateral testicles and central nervous system sanctuary sites. Several molecular aberrations, including somatic mutation of MYD88, CD79B, and upregulation of NF-kB, PDL-1, and PDL-2, are thought to contribute to the pathogenesis and poor prognosis of PTL. However, additional biomarkers are needed that may improve the prognosis and help understand the PTL biology and lead to new therapeutic targets. RNA from diagnostic tissue biopsies of the PTL-ABC subtype and matched nodal DLBCL-ABC subtype patients was evaluated by mRNA and miRNA expression. Screening of 730 essential oncogenic genes was performed, and their epigenetic connections were examined using the nCounter PAN-cancer pathway, and Human miRNA assays with the nCounter System (NanoString Technologies). PTL and nodal DLBCL patients were comparable in age, gender, and putative cell of origin (p > 0.05). Wilms tumor 1 (WT1) expression in PTL exceeded that in nodal DLBCL (>6-fold; p = 0.01, FDR <0.01) and WT1 associated pathway genes THBS4, PTPN5, PLA2G2A, and IFNA17 were upregulated in PTL (>2.0-fold, p < 0.01, FDR <0.01). Additionally, miRNAs targeting WT1 (hsa15a-5p, hsa-miR-16-5p, has-miR-361-5p, has-miR-27b-3p, has-miR-199a-5p, has-miR-199b-5p, has-miR-132-3p, and hsa-miR-128-3p) showed higher expression in PTL compared to nodal DLBCL (≥2.0-fold; FDR 0.01). Lower expression of BMP7, LAMB3, GAS1, MMP7, and LAMC2 (>2.0-fold, p < 0.01) was observed in PTL compared to nodal DLBCL. This research revealed higher WT1 expression in PTL relative to nodal DLBCL, suggesting that a specific miRNA subset may target WT1 expression and impact the PI3k/Akt pathway in PTL. Further investigation is needed to explore WT1's biological role in PTL and its potential as a therapeutic target. - Source: PubMed
Publication date: 2023/06/08
Mansoor AdnanAkhter ArizShabani-Rad Meer-TaherDeschenes JeanYilmaz AsliTrpkov KirilStewart Douglas