IGF2R antibody Polyclonal Antibodies Primary antibodies
- Known as:
- IGF2R (anti-) Polyclonal Antibodies Primary antibodies
- Catalog number:
- orb100167
- Product Quantity:
- 100
- Category:
- -
- Supplier:
- Biorb
- Gene target:
- IGF2R antibody Polyclonal Antibodies Primary antibodies
Related genes to: IGF2R antibody Polyclonal Antibodies Primary antibodies
- Gene:
- AIRN NIH gene
- Name:
- antisense of IGF2R non-protein coding RNA
- Previous symbol:
- -
- Synonyms:
- AIR, NCRNA00088, IGF2RAS, IGF2R-AS1
- Chromosome:
- 6q25.3
- Locus Type:
- RNA, long non-coding
- Date approved:
- 2008-11-25
- Date modifiied:
- 2018-08-15
- Gene:
- IGF2R NIH gene
- Name:
- insulin like growth factor 2 receptor
- Previous symbol:
- -
- Synonyms:
- CD222, MPRI, MPR1, CIMPR, M6P-R, CI-M6PR, CI-MPR, MPR300
- Chromosome:
- 6q25.3
- Locus Type:
- gene with protein product
- Date approved:
- 1988-07-07
- Date modifiied:
- 2019-04-23
Related products to: IGF2R antibody Polyclonal Antibodies Primary antibodies
Related articles to: IGF2R antibody Polyclonal Antibodies Primary antibodies
- Genomic imprinting is critical for mammalian development, but its regulation varies across species. The insulin-like growth factor 2 receptor (IGF2R), which is a maternally expressed imprinted gene critical for cell proliferation and differentiation, as well as embryonic and placental development, is classically regulated by differentially methylated regions (DMRs) and lncRNA- in mice. However, studies on this in equus are scarce, especially in terms of mechanistic studies. In the present study, heart, liver, spleen, lung, kidney, brain, and muscle samples were obtained from horses, donkeys, and hybrids, and gene expression and imprinting state were tested to investigate the imprinting regulation of in these animals. Bisulfite sequencing combined with an allele-specific expression analysis revealed a tissue-specific loss of imprinting in the mule liver and hybrid brain tissues. Strikingly, we found that the maternal-specific expression of equine did not rely on the canonical DMRs or lncRNA-. Surprisingly, DNA methylation of a specific region called CpG island 2 (CpGI2) in the promoter showed -acting inheritance, meaning that the DNA methylation patterns of the parental alleles are retained in hybrid tissues. Notably, the DNA methylation of CpGI2 correlated negatively with expression in the spleen (R = 0.8797, = 6.46 × 10), lung (R = 0.8569, = 1.57 × 10), and kidney (R = 0.8650, = 3.85 × 10). Our findings suggest that imprinting may work differently in other species. This study provides a framework for understanding imprinting diversity in hybrids and shows that equine hybrids can be used to study how epigenetic inheritance works. - Source: PubMed
Publication date: 2025/06/11
Wang XishengShen YingchaoRen HongYi MinnaBou Gerelchimeg - Genomic imprinting plays critical roles during the development of mammalian species and underlying epigenetic mechanisms frequently involve long non-coding RNAs (lncRNAs). The paternal transcription of the antisense Igf2r RNA noncoding (Airn) is responsible for paternal silencing of the mouse insulin-like growth factor 2 receptor (Igf2r) gene and maternal Igf2r expression. Although the corresponding maternal DNA methylation imprint is conserved in humans and pigs, the orthologous AIRN lncRNA has been identified in humans but not in pigs. Here, we aimed to examine imprinted allelic expression of the porcine AIRN lncRNA along with a corresponding differentially methylated region (DMR) and to analyze allelic expression of AIRN and IGF2R in pigs. By comparing parthenogenetic and control porcine embryos, we identified a maternally methylated DMR and a significantly higher expression of AIRN lncRNA in control embryos (P < 0.05) indicating its paternal expression. Further analyses revealed that the expression of AIRN lncRNA was enriched in the pig brain and its subregions, and it was monoallelically expressed; whereas, IGF2R was expressed biallelically suggesting an absence of allele-specific transcriptional regulation. Our findings will lead to further investigations into the role of the imprinted porcine AIRN lncRNA during pig development. - Source: PubMed
Ahn JinsooHwang In-SulPark Mi-RyungHwang SeongsooCho In-CheolLee Kichoon - Acute liver injury is a common and serious syndrome caused by multiple factors and unclear pathogenesis. If the injury persists, liver injury can lead to cirrhosis and liver failure and ultimately results in the development of liver cancer. Emerging evidence has indicated that long noncoding RNAs (lncRNAs) play an important role in the development of liver injury. However, the role of antisense Igf2r RNA (Airn) in acute liver injury and its underlying mechanism remain largely unclear. In this study, we show that Airn is upregulated in liver tissue and primary hepatocytes from an acute liver injury mouse model. Consistently, Airn is also overexpressed in serum samples of patients with acute-on-chronic liver failure and is negatively correlated with the Model for End-Stage Liver Disease (MELD) score. Moreover, gene knockout and rescue assays reveal that Airn alleviates CCl -induced liver injury by inhibiting hepatocyte apoptosis and oxidative stress . Further investigation reveals that Airn decreases H O -induced hepatocyte apoptosis . Mechanistically, we reveal that Airn represses CCl - and H O -induced enhancement of phosphorylation of p65 and IκBα, suggesting that Airn inhibits hepatocyte apoptosis by inactivating the NF-κB pathway. In conclusion, our results demonstrate that Airn can alleviate acute liver injury by inhibiting hepatocyte apoptosis via inactivating the NF-κB signaling pathway, and Airn could be a potential biomarker for acute liver injury. - Source: PubMed
Shao ShuaiZhang YuZhou FengMeng XiaoxiangYu ZhenjunLi GuantongZheng LinaZhang KunLi YuhanGuo BeichenLiu QiZhang MengxiaDu XiaoxiaoHong WeiHan Tao - The eutherian IGF2R imprinted domain is regulated by an antisense long non-coding RNA, Airn, which is expressed from a differentially methylated region (DMR) in mice. Airn silences two neighbouring genes, Solute carrier family 22 member 2 (Slc22a2) and Slc22a3, to establish the Igf2r imprinted domain in the mouse placenta. Marsupials also have an antisense non-coding RNA, ALID, expressed from a DMR, although the exact function of ALID is currently unknown. The eutherian IGF2R DMR is located in intron 2, while the marsupial IGF2R DMR is located in intron 12, but it is not yet known whether the adjacent genes SLC22A2 and/or SLC22A3 are also imprinted in the marsupial lineage. In this study, the imprinting status of marsupial SLC22A2 and SLC22A3 in the IGF2R imprinted domain in the chorio-vitelline placenta was examined in a marsupial, the tammar wallaby. - Source: PubMed
Publication date: 2022/08/27
Ishihara TeruhitoGriffith Oliver WSuzuki ShunsukeRenfree Marilyn B - Evidence has demonstrated that puerarin is a potential medicine for the treatment of cardiac hypertrophy. However, the precise underlying molecular mechanisms of the protective effect of puerarin are still unclear. Here, we aimed to explore the regulatory mechanisms of lncRNAs/mRNAs co-expression network in a cardiac hypertrophy mouse model after puerarin treatment. - Source: PubMed
Publication date: 2022/04/05
Ye ShanChen WeiyanOu CaiwenChen Min-Sheng