ORP4 antibody Polyclonal Antibodies Primary antibodies
- Known as:
- ORP4 (anti-) Polyclonal Antibodies Primary antibodies
- Catalog number:
- orb100156
- Product Quantity:
- 100
- Category:
- -
- Supplier:
- Biorb
- Gene target:
- ORP4 antibody Polyclonal Antibodies Primary antibodies
Related genes to: ORP4 antibody Polyclonal Antibodies Primary antibodies
- Gene:
- OSBP2 NIH gene
- Name:
- oxysterol binding protein 2
- Previous symbol:
- OSBPL1
- Synonyms:
- KIAA1664, ORP-4, ORP4
- Chromosome:
- 22q12.2
- Locus Type:
- gene with protein product
- Date approved:
- 1999-10-29
- Date modifiied:
- 2014-11-19
Related products to: ORP4 antibody Polyclonal Antibodies Primary antibodies
Related articles to: ORP4 antibody Polyclonal Antibodies Primary antibodies
- Methane (CH) emissions present a significant challenge to both environmental sustainability and energy efficiency in ruminants, including beef cattle that are born in dairy herds. Although numerous approaches, including alterations in feed and the use of additives, are under investigation to mitigate these emissions, the genetic selection of animals that produce lower levels of methane offers the potential for enduring and cumulative advantages. Transcriptome analysis represents a crucial advancement in elucidating the networks and mechanisms through which the ruminant genome influences methane emissions. In the present study, methane emissions were measured using a GreenFeed system in beef-on-dairy cattle ( = 11). High-throughput RNA sequencing was conducted on animal blood samples, followed by differential gene expression analysis using methane production (g/d) as a continuous trait. The analysis identified eleven differentially expressed genes (DEGs), including six downregulated (, , , , , ) and five upregulated (, , , , ) genes (adj < 0.05) with one gene exhibiting potential biomarker characteristics. Gene and cell enrichment, as well as pathway analysis, suggested that nervous, immune, and endocrine systems may be involved in ruminal methane production by beef-on-dairy cattle. These findings highlight the potential of transcriptomic biomarkers to guide genetic selection strategies, offering a sustainable pathway to reduce methane emissions and enhance both environmental and agricultural efficiency. - Source: PubMed
Publication date: 2026/02/13
Razban VahidCarballo Omar CristobalMorrison StevenShirali Masoud - Sex-related hormones and proteins may underlie sex differences in alcohol use disorder characteristics and consequences. Previous reports suggest steroid sex hormones may influence alcohol consumption behaviors while proteins that regulate their circulation levels are rarely investigated. Following up on our earlier study of individual sex-related hormones' associations with alcohol dependence (AD), this study measured the associations between the combinations of sex-related hormones and proteins and AD in a larger sample. - Source: PubMed
Publication date: 2025/06/16
Ho Ada Man-ChoiGeske Jennifer RPazdernik Vanessa KWaller T CameronBatzler AnthonyWinham Stacey JKarpyak Victor M - Ovarian development is a complex process, with early stages laying a crucial foundation for subsequent egg production. To better understand this developmental trajectory from early stages to the peak of egg production, this study employed transcriptomic and Tandem Mass Tag (TMT) proteomic analyses. These methods were used to compare gene and protein expression profiles in the ovaries of Taihe black-boned silky fowl (TBSF) at 20 weeks (20W) and 30 weeks (30W) of age, aiming to identify key regulatory mechanisms. Serum levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), and progesterone (P4) at 30 W were found to be higher than those at 20 W, indicating potential involvement of these hormones in ovarian maturation and the initiation of peak egg production. Meanwhile, a total of 4,563 genes and 154 proteins were analyzed, revealing 1,677 upregulated and 2,886 downregulated genes, along with 29 upregulated proteins and 125 downregulated proteins. In the early stages, key pathways such as collagen synthesis, cell adhesion, and ECM-receptor interaction were enriched, suggesting their potential roles in cellular proliferation and matrix development, which may contribute to early egg-laying. During the peak egg-laying period, pathways related to cholesterol and steroid biosynthesis were notably active, potentially supporting the hormonal demands associated with increased egg production. The integrated multi-omics results identified potential candidate genes associated with ovarian development, including COL12A1, COL1A2, ANXA2, ANXA5, OSBP2, LGMN, EDNRA, CRISPLD2, SERPINF2, CYP17A1, YES1, and HSD17B1. These findings provide a foundation for understanding the ovarian development of TBSF hens from early stages to the peak of egg production, and help elucidate the molecular mechanisms underlying ovarian development in this breed. - Source: PubMed
Publication date: 2025/05/31
Huang XuanXu ChunhuiLi ShibaoTan YutingHuang YunyanYin Zhaozheng - In 2005-2006, a chikungunya epidemic of unprecedented magnitude hit Reunion Island, which raised a public health concern through the substantial proportions of long-lasting manifestations. To understand the pathophysiology underlying chronic chikungunya (CC), we designed the CHIKGene cohort study and collected blood samples from 133 subjects diagnosed with CC and from 86 control individuals that had recovered within 3 months, 12-to-15 years after exposure. - Source: PubMed
Publication date: 2025/02/23
Gérardin PatrickMedina-Santos RaissaLe Clerc SigridBruneau LéaMaillot AdrienLabib TaoufikRahmouni MyriamSpadoni Jean-LouisMeyniel Jean-PhilippeCornet ClémenceLefebvre CécileEl Jahrani NoraSavara JakubMathew Mano JosephFontaine ChristinePayet ChristineAh-You NathalieChabert CécileMussard CorinnePorcherat SylvaineMedjane SamirNoirel JosselinMarimoutou CatherineHocini HakimZagury Jean-François - Undifferentiated spermatogonia (Undiff-SPG) plays a critical role in maintaining continual spermatogenesis. However, the toxic effects and molecular mechanisms of maternal exposure to nanoplastics on offspring Undiff-SPG remain elusive. Here, we utilized a multiomics combined cytomorphological approach to explore the reproductive toxicity and mechanisms of polystyrene nanoplastics (PS-NPs) on offspring Undiff-SPG in mice after maternal exposure. The results indicated that PS-NPs decreased testosterone levels and reduced sperm concentration and quality in offspring male mice through maternal exposure. Moreover, PS-NPs could enter offspring Undiff-SPG, increase ROS levels, and decrease the viability of Undiff-SPG. According to the transcriptomics and proteomics analyses, PS-NPs caused offspring male mice Undiff-SPG inflammation by increasing the expression of /. Mechanistically, we found that inflammation induced overexpression of the transcription factor in Undiff-SPG, which suppressed the expression of and . Additionally, PS-NPs disrupted offspring spermatogenesis by inhibiting the // expression. Furthermore, PS-NPs reduced the Undiff-SPG autophagic flux by reducing the expression of /. In conclusion, maternal exposure to PS-NPs caused inflammation in offspring Undiff-SPG, which resulted in overexpression that could disrupt spermatogenesis and normal autophagy. - Source: PubMed
Publication date: 2025/01/10
Ma ShengLi SisiJiang ShengyaoWang LiruiZhan DianXiong ManyiJiang YanpingHuang QixianKui HaozhanLi Xinhong