TEM7R antibody Polyclonal Antibodies Primary antibodies
- Known as:
- TEM7R (anti-) Polyclonal Antibodies Primary antibodies
- Catalog number:
- orb100151
- Product Quantity:
- 100
- Category:
- -
- Supplier:
- Biorb
- Gene target:
- TEM7R antibody Polyclonal Antibodies Primary antibodies
Related genes to: TEM7R antibody Polyclonal Antibodies Primary antibodies
- Gene:
- PLXDC2 NIH gene
- Name:
- plexin domain containing 2
- Previous symbol:
- -
- Synonyms:
- TEM7R, FLJ14623
- Chromosome:
- 10p12.31
- Locus Type:
- gene with protein product
- Date approved:
- 2003-08-27
- Date modifiied:
- 2016-10-05
Related products to: TEM7R antibody Polyclonal Antibodies Primary antibodies
Related articles to: TEM7R antibody Polyclonal Antibodies Primary antibodies
- Chronic lung allograft dysfunction (CLAD) leads to declining respiratory function and high mortality, representing the main barrier to long-term survival in lung transplantation (LT). We performed the first genome-wide association study (GWAS) investigating donor's and recipient's genetic factors associated with CLAD. - Source: PubMed
Publication date: 2026/03/19
Brocard SimonMauduit VincentMorin MartinBoussamet LéoSilva Nayane Dos Santos BritoDurand AxelleHalitim PierreRenaud-Picard BenjaminCoiffard BenjaminDemant XavierFalque LoïcLe Pavec JéromeRoux AntoineVilleneuve ThomasKnoop ChristianeMerveilleux ClaireSalpin MathildeCarlier NicolasGourraud Pierre AntoineMagnan AntoineLair DavidBerthelot LaurelineSüdholt MarioVince NicolasTissot AdrienLimou Sophie - Whole-genome sequencing (WGS) is a powerful tool for uncovering genome-wide variation, identifying selection signatures, and guiding genetic improvement in livestock. Royal White (RW) and White Dorper (WD) sheep are economically important meat-type hair breeds in the U.S., yet their genomic architecture remains poorly characterized. In this study, WGS was performed on 20 ewes ( = 11 RW, = 9 WD) to identify and annotate SNPs and small insertions and deletions (indels). Functional annotation, gene enrichment, population structure, and selective sweep analysis were also performed. Selective sweep analysis was conducted by integrating the fixation index (F), nucleotide diversity (π), and Tajima's D to identify candidate regions under putative recent positive selection. A total of 21,957,139 SNPs and 2,866,600 indels were identified in RW sheep, whereas 18,641,789 SNPs and 2,397,368 indels were identified in WD sheep. In RW sheep, candidate genes under selection were associated with health and parasite resistance (, , ) and growth traits (). In WD sheep, selective sweep regions included genes linked to immune response and parasite resistance (), body weight (), and reproduction (). These findings were supported by sheep-specific quantitative trait loci (QTL) annotations and previously reported SNP-trait associations. This study provides the first WGS-based genomic comparison between RW and WD sheep, establishing a foundation for future genetic improvement, including targeted selection for enhanced immune function, disease resistance, and other economically important traits in these breeds. - Source: PubMed
Publication date: 2026/03/05
Liao MingsiKravitz AmandaHaak David CSriranganathan NammalwarCockrum Rebecca R - Immunometabolism exerts a bimodal action at the interface of extracellular immune response and intracellular metabolism, putting it at the center of many immune-mediated inflammatory disorders (IMIDs). Research has shown that immunometabolic pathways may act as a dual checkpoint for the inflammatory cycle to return the system to homeostasis by inactivating inflammatory pathways and shifting metabolism in favor of regulatory phenotypes. In addition, immunometabolic targets may act in non-immune cells such as epithelial and mesenchymal cells. Therefore, the therapeutic approach to targeting the uniquely robust mechanisms of immunometabolism may ameliorate aspects of IMIDs that remained to be addressed. Several emerging targets, including mitochondrial regulators (eg NLRX1), membrane-bound receptors (eg PLXDC2), and hormonal peptides (eg GLP-1), illustrate the diverse ways immunometabolism can be leveraged therapeutically. Preclinical models of inflammatory bowel disease (IBD) and other IMIDs have highlighted the bimodal immunoregulatory roles of these pathways. Preliminary clinical data support the potential utility of immunometabolic modulation, particularly in combination with existing therapies, to overcome the current therapeutic ceiling in clinical efficacy. Continued research is needed to validate the efficacy, safety, and mechanistic precision of immunometabolic agents across the spectrum of IMIDs. - Source: PubMed
Solitano VirginiaPeyrin-Biroulet LaurentVermeire SeverineDubinsky Marla CSiegmund BrittaMosig RebeccaCataldi FabioDerluyn LouisDanese SilvioVerstockt Bram - Alzheimer's disease (AD) is a devastating neurodegenerative disorder, and early intervention remains the only reliable strategy to slow its progression. Notably, cerebrospinal fluid (CSF) metabolites play a crucial role in the early diagnosis of AD, making their investigation highly significant. - Source: PubMed
Publication date: 2026/01/06
Jiang SiyiQi PingTian JiaLiu HuaizhengSun Chuanzheng - Numerous strategies exist to isolate hematopoietic stem cells (HSCs) using complex combinations of markers and flow cytometry. However, robust identification of HSCs using imaging techniques is substantially more challenging which has prompted the recent development of HSC reporter mice. To date, very few molecules used in these reporters have been useful for human HSC identification. Here we report that PLXDC2 is a useful marker for both mouse and human cord blood HSCs. Using a green fluorescent protein (GFP) knock-in at the Plxdc2 locus in mice (hereafter denoted as Plxdc2-GFP), we showed that Plxdc2-GFP is highly expressed in HSCs with 1 in 2.8 Plxdc2-GFPCD150 cells giving long-term multi-lineage reconstitution in transplantation. Moreover, we developed a novel human PLXDC2 antibody and showed that human PLXDC2 HSCs have higher long-term multilineage reconstitution ability compared with PLXDC2 HSCs in a xenograft model. This study identifies PLXDC2 as a highly relevant molecule in HSC identification. - Source: PubMed
Publication date: 2025/12/10
Tanaka YosukeKubota YasushiKikuchi RikoYabushita TomohiroKimura TakaharuLieberam IvoBarlow Jillian LBramley Josh WFukushima TsuyoshiSakuma ChiakiShibata TakashiNakagawa MasatakaKurosawa YasunoriMaruyama ToshiakiOkumura C JArima YuichiroSato YoshinoriOno YasuoAkuta TeruoMizuno HidenobuKent David GJessell Thomas MGoyama SusumuNishikii HidekazuKimura ShinyaYamazaki SatoshiSuda ToshioKitamura Toshio