VAV2 antibody Polyclonal Antibodies Primary antibodies
- Known as:
- VAV2 (anti-) Polyclonal Antibodies Primary antibodies
- Catalog number:
- orb100132
- Product Quantity:
- 100
- Category:
- -
- Supplier:
- Biorb
- Gene target:
- VAV2 antibody Polyclonal Antibodies Primary antibodies
Related genes to: VAV2 antibody Polyclonal Antibodies Primary antibodies
- Gene:
- VAV2 NIH gene
- Name:
- vav guanine nucleotide exchange factor 2
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 9q34.2
- Locus Type:
- gene with protein product
- Date approved:
- 1994-07-15
- Date modifiied:
- 2016-10-05
Related products to: VAV2 antibody Polyclonal Antibodies Primary antibodies
Related articles to: VAV2 antibody Polyclonal Antibodies Primary antibodies
- Testicular germ cell tumors (TGCT) are highly heritable malignancies that display increasing incidence worldwide, with rising mortality rates particularly evident among Hispanic men. However, genomic studies of TGCT have largely focused on European cohorts, limiting accurate risk prediction in other populations. We investigated rare germline variants contributing to TGCT susceptibility in a Hispanic cohort. Exome sequencing data (mean depth 60x) from 40 Mexican TGCT patients were analyzed against two ancestry-matched control groups using gene-based aggregation analyses and single-variant association. Top candidate variants were validated and replicated in an independent cohort of 211 TGCT patients, with Mexican individuals from the PAGE study serving as a third control group. Gene-based testing revealed seven genes, including , and , with nominal associations. Three previously unreported variants: rs2273499 in (OR 3.72), rs147153778 in (OR 2.21), and rs79783591 in (OR 2.31), showed statistically significant results and consistent directionality in the replication cohort, representing suggestive TGCT risk variants that warrant further validation, although none reached exome-wide significance. All three also displayed preliminary associations with mortality, indicating potential prognostic relevance. These findings provide exploratory, population-enriched signals of genetic susceptibility to TGCT in Hispanics. Altogether, they emphasize the critical need for more inclusive genomic research in underrepresented populations and provide a foundation for future investigations aimed at improving population-tailored risk assessment and prognostic tools. - Source: PubMed
Publication date: 2026/04/20
Cuevas-Estrada BereniceRíos-Rodríguez Juan AGarcía-Pacheco José AWegman-Ostrosky TaliaCervera AlejandraAlcaraz NicolasMontalvo-Casimiro MichelBarrón-Hernández AlejandraCastro-Hernández ClementinaJiménez-Ríos Miguel ASobrevilla-Moreno NoraArriaga-Canon CristianHerrera Luis AGonzález-Barrios Rodrigo - Thrombosis was recognized as a significant cause of morbidity and mortality for prostate cancer (PCa). The potential mechanisms underlying the effect of thrombosis on PCa remain elusive. - Source: PubMed
Publication date: 2026/02/19
Luo YongChen PeixianSitu MinyiZhuang WeiHuang JinxingWang BaojunWang QiongPeng ShengmengHuang Hai - Creating artificial organelles that sequester and release specific proteins in response to a small molecule in mammalian cells is an attractive approach for regulating protein function. In this work, by combining phase-separated condensates formed by the tandem fusion of two oligomeric proteins with a trimethoprim (TMP)-responsive nanobody switch for GFP (LAMA; ligand-modulated antibody fragment), we developed a synthetic condensate system that initially sequesters GFP-tagged proteins within condensates and rapidly releases them into the cytoplasm upon TMP treatment. The released proteins can then be resequestered by washing out the TMP. This system enabled user-defined, temporal, rapid, and reversible control of cellular processes, including membrane ruffling mediated by exogenously expressed GFP-Vav2 and modulation of the cellular localization of endogenous ERK2-GFP generated by genome knock-in. Our results highlight the utility of the LAMA-based synthetic condensate platform as a novel, chemically switchable tool for regulating protein function through controlled protein sequestration and release in mammalian cells. - Source: PubMed
Publication date: 2025/12/14
Fukaya YokoYoshikawa MasaruAoki KazuhiroFarrants HelenJohnsson KaiTsukiji Shinya - Microexons exhibit striking evolutionary conservation and are subject to precise, switch-like regulation in neurons, orchestrated by the splicing factors and . Disruption of these regulators in mice leads to severe neurological phenotypes, and their misregulation is linked to human disease. However, the specific microexons involved in these phenotypes and the effects of individual microexon deletions on neurodevelopment, physiology, and behavior remain poorly understood. To explore this, we generated zebrafish lines with deletions of 18 individual microexons, alongside and mutant lines, and conducted comprehensive phenotypic analyses. We discovered that while loss of , alone or together with , resulted in significant alterations in neuritogenesis, locomotion, and social behavior, individual microexon deletions typically produced mild or no noticeable effects. Nonetheless, we identified specific microexons associated with defects in neuritogenesis (, , , ) and social behavior (, ). Additionally, most microexon deletions triggered coordinated transcriptomic changes in neural pathways, suggesting the presence of molecular compensatory mechanisms. Our findings suggest that the severe phenotypes caused by depletion arise from the combined effects of multiple subtle disruptions across various cellular pathways, which are individually well-tolerated. - Source: PubMed
Publication date: 2025/11/18
Lopez-Blanch LauraRodríguez-Marin CristinaMantica FedericaIñiguez Luis PPermanyer JonKita Elizabeth MMackensen TahneeCodina-Tobias MireiaRomero-Ferrero FranciscoFernandez-Albert JordiCuadrado MyriamBustelo Xosé Rde Polavieja GonzaloIrimia Manuel - The cytoskeleton has been described as a regulator of adrenal physiology and tumour behaviour. In the adrenal cortex, both cytoskeletal filaments, by mediating cholesterol transfer to mitochondria, and their binding proteins, such as cofilin and diaphanous-related formin 1 (DIAPH1), have been implicated in modulating steroidogenic processes. Beyond hormone production, the cytoskeleton participates in oncogenic signalling and contributes to the acquisition of malignant behaviour in adrenocortical carcinoma (ACC). Cytoskeleton-associated proteins such as filamin A (FLNA), fascin-1 (FSCN1), RASSF1A, and the guanine nucleotide exchange factor VAV2 are involved in signal transduction, cell cycle regulation, and cytoskeletal remodelling. In ACC, dysregulation of the expression or activity of these proteins correlates with ACC aggressiveness, including increased proliferation, motility, and invasion as well as poor prognosis, making them attractive candidates for targeted therapeutic strategies. To date, no review has systematically addressed the role of cytoskeleton and its binding partners in both adrenal physiological regulation and pathological context. This review is the first to provide a comprehensive overview of cytoskeletal involvement in adrenal cortex function and cancer, highlighting emerging molecular players and their possible therapeutic implications. - Source: PubMed
Publication date: 2025/10/24
Catalano RosaNozza EmmaEsposito EmanuelaDi Bari SoniaMantovani GiovannaPeverelli Erika