LOXL4 antibody Polyclonal Antibodies Primary antibodies
- Known as:
- LOXL4 (anti-) Polyclonal Antibodies Primary antibodies
- Catalog number:
- orb100094
- Product Quantity:
- 100
- Category:
- -
- Supplier:
- Biorb
- Gene target:
- LOXL4 antibody Polyclonal Antibodies Primary antibodies
Related genes to: LOXL4 antibody Polyclonal Antibodies Primary antibodies
- Gene:
- LOXL4 NIH gene
- Name:
- lysyl oxidase like 4
- Previous symbol:
- -
- Synonyms:
- FLJ21889, LOXC
- Chromosome:
- 10q24.2
- Locus Type:
- gene with protein product
- Date approved:
- 2001-11-14
- Date modifiied:
- 2016-10-05
Related products to: LOXL4 antibody Polyclonal Antibodies Primary antibodies
Related articles to: LOXL4 antibody Polyclonal Antibodies Primary antibodies
- Glioblastoma (GBM) is the most common malignant brain tumor, and effective therapeutic strategies remain scarce. Therefore, the study aims to screen biomarkers to reveal the molecular mechanisms of cancer stem cells (CSCs) and disulfidptosis in GBM therapy. - Source: PubMed
Publication date: 2026/02/27
Tang DangRen ZhongkunGao BiboLong Jiang - Spondylolisthesis is a spinal disorder characterized by abnormal vertebral displacement, primarily affecting the lumbar region. Understanding the genetic factors underlying its progression is critical. - Source: PubMed
Publication date: 2026/02/04
Wang HuiNiu PengYang XiuLin XinLi JinquanWu GuangyinSun XiaotangHuang JianghuLin Feiyue - Peripheral neuropathies are common neurological disorders affecting sensory, autonomic, and motor nerves, with an estimated prevalence exceeding 2% in the general population. Typical symptoms include numbness and distal limb muscle weakness, resulting from somatosensory nerve damage. Here, we investigate the genetic architecture of mono- and polyneuropathies and their relationships with comorbid traits using data from FinnGen and the UK Biobank. Our genome-wide association study (GWAS) and meta-analysis identified 48 genome-wide significant (P < 5 × 10-8) independent loci and 66 fine-mapped credible sets. These included associations with genes involved in neurotransmitter signaling (HTR3A), immune function (HLA-DQB1, BCL11A), extracellular matrix remodeling (COL11A1, ADAMTS17, LOXL4), axon guidance and neural development (DCC, ETV1, NEGR1), and carpal tunnel syndrome (DIRC3). Public variant association data across cohorts, genetic correlation, and Mendelian randomization analyses supported shared genetic links of neuropathies with sleep problems, chronic pain, and psychiatric disorders. Together, our results highlight a strong polygenic basis for neuropathies and further confirm their genetic comorbid relationships with sleep, pain, psychiatric, and autoimmune traits. - Source: PubMed
Broberg MartinGen FinnKalso EijaOllila Hanna M - Lysyl oxidase (LOXs) are copper-dependent enzymes traditionally known for catalyzing the cross-linking of collagen and elastin, thereby ensuring extracellular matrix (ECM) stability. However, growing evidence reveals that their biological functions extend far beyond ECM remodeling. This review highlights the diverse roles of the LOX family, comprising LOX, LOXL1, LOXL2, LOXL3, and LOXL4, in tissue repair, vascular remodeling, inflammation, and cancer. Each isoform exhibits unique structural domains, regulatory pathways, and functional interactions with signaling cascades such as TGF-β, PDGF, VEGF, and HIF-1α. LOXs are essential for wound healing, coordinating ECM synthesis and cross-linking during different phases of tissue regeneration. Their expression is tightly modulated by inflammatory cytokines, and their dysregulation has been implicated in pathological fibrosis and impaired tissue repair. In cancer, LOXs contribute to epithelial-to-mesenchymal transition (EMT), cell invasion, and metastasis through both enzymatic and non-enzymatic mechanisms, including intracellular signaling, Snail1 stabilization, and cytoskeletal modulation. They also influence angiogenesis by regulating VEGF expression and promoting endothelial cell activation via PDGFRβ-AKT signaling. Intracellular and nuclear functions further expand their impact on gene regulation and chromatin structure. Given their involvement in matrix dynamics, mechanotransduction, and cell fate determination, LOXs emerge as key players in both physiological and pathological contexts. Understanding their multifactorial roles opens potential avenues for therapeutic targeting in cancer, fibrosis, and chronic inflammatory diseases. - Source: PubMed
Publication date: 2025/12/18
Boaru Diego LiviuDe Leon-Oliva DiegoFraile-Martinez OscarDe Castro-Martinez PatriciaGarcia-Montero CieloFerrara-Coppola ConnieMichael Alhaddadin Majd NBarrena-Blázquez SilvestraPeñas-González Cristina De LasHolgado-Tirado NoemíTordesillas-Vicente MónicaTorres-Carranza DiegoLopez-Gonzalez LauraDiaz-Pedrero RaulAlvarez-Mon MelchorSaez Miguel AOrtega Miguel A - Subconjunctival bleeding in neonatal calves is most commonly seen in association with birth trauma. There are currently no investigations available that examine the systemic causes of this phenomenon. In this prospective and exploratory case-control study, seven out of eighty neonatal calves examined over a two-year period were born with subconjunctival bleeding. The anatomical location of the subconjunctival bleeding and details related to the cow's and calf's parturitional and gestational history were recorded. Blood samples from cases and controls ( = 7) were analyzed hematologically, and the serum lysyl oxidase-like enzyme 4 (LOXL4) concentration was determined through an ELISA to establish evidence for possible structural, copper-dependent vascular abnormalities. We found no significant difference in the clinical data of both groups. Hematological examinations revealed no evidence of anemia or thrombocytopenia. Additionally, no significant differences in differential leukocyte counts were observed between the different groups. However, the neutrophil-lymphocyte ratio (NLR) demonstrated a significant difference between the calves with subconjunctival bleeding and controls. The serum LOXL4 protein concentration was not significantly different in calves with subconjunctival bleeding compared to controls. In conclusion, our clinical, hematological, and biochemical data provided no evidence for potential systemic causes of subconjunctival bleeding. However, these results must be considered in light of this study's small sample size and thus low statistical power. - Source: PubMed
Publication date: 2025/11/21
Steffl MartinEuchner KatharinaNautscher Nadine