BRCC4 antibody Polyclonal Antibodies Primary antibodies
- Known as:
- BRCC4 (anti-) Polyclonal Antibodies Primary antibodies
- Catalog number:
- orb100084
- Product Quantity:
- 100
- Category:
- -
- Supplier:
- Biorb
- Gene target:
- BRCC4 antibody Polyclonal Antibodies Primary antibodies
Related genes to: BRCC4 antibody Polyclonal Antibodies Primary antibodies
- Gene:
- BABAM2 NIH gene
- Name:
- BRISC and BRCA1 A complex member 2
- Previous symbol:
- BRE
- Synonyms:
- BRCC45, BRCC4
- Chromosome:
- 2p23.2
- Locus Type:
- gene with protein product
- Date approved:
- 1999-04-23
- Date modifiied:
- 2017-03-30
Related products to: BRCC4 antibody Polyclonal Antibodies Primary antibodies
Related articles to: BRCC4 antibody Polyclonal Antibodies Primary antibodies
- Fosab is a key transcription factor to regulate the proliferation cycle of satellite cells in mammalian skeletal muscle. To verify its regulatory function in mandarin fish (Siniperca chuatsi) satellite cells, a whole-genome identification and evolutionary analysis were conducted, and the regulation of fosab to satellite cells development was explored by both gene overexpressing and knocking down analysis. The results revealed that mandarin fish have 5 fos family members (fosaa, fosab, fosb, fosl1a, and fosl2), which are relatively lowly conserved (36.0 %-88.6 %) in amino acid among vertebrates. In teleosts, fosaa, fosab, and fosl1a were evolved through the third genome duplication event, accompanied with chromosomal rearrangements which resulted in co-localized fosaa and fosl2 on the same chromosome. Some synchronous evolution of conserved gene clusters, such as fosaa-jdp2a and mocs1-fosl2-babam2-rbks-mrpl33 were also abserved. In the tissue and developmental expression trends, fos members showed highly expression in gill, brain and liver (P < 0.05). In skeletal muscle, all members reached their highest expression levels on the 5th day post hatching (5 dph) (P < 0.05). The muscular injury model for mechanistic investigation showed that pax7, myod, and myf5 level significantly increased/decreased (P < 0.05) on the 4th days after injury. The number of pax7 cells significantly increased (P < 0.05), with a significant upregulation of fosab expression (P < 0.05), indicating that the proliferation activity of satellite cells was highest at the 4th days after injury. Under this model, overexpressing or knocking down the level of fosab could significantly increase or decrease the number of pax7 cells and the expression levels of cyclin genes like cyca, cycd, and cdk2, as well as myogenic marker genes such as myog and myf6 (P < 0.05). In conclusion, fosab could promote the growth of myoblasts by speeding up the satellite cell cycle in mandarin fish. - Source: PubMed
Publication date: 2025/12/03
Yao XiaoliLiu YufeiKadira Hossam IGao JinhuaQian YezhouZhao YanTang ShoujieZhao Jinliang - - Source: PubMed
Publication date: 2025/07/18
Lin MingHuiChen XuYuLin FanYang YanBo - Sheep have demonstrated remarkable adaptability to diverse and unproductive pastures, making them highly advantageous in the context of sustainable farming practices in the globally warming world. Despite their adaptation skills, local sheep breeds generally exhibit low performance, highlighting the need to develop desired traits. Traditional Mixed Linear Model (MLM)-based single-locus Genome-Wide Association (GWA) studies may fall short in identifying multiple loci influencing traits due to their linear genome scanning approach, rendering them less effective for detecting polygenic effects. - Source: PubMed
Publication date: 2025/08/08
Yaman YalçınAymaz RamazanKeleş MuratKişi Yiğit EmirHatipoğlu EcemÖzdemir ArzuÇetinkaya Elif - HPV infection is common among women and can result in serious illnesses. This research utilizes single-cell RNA-sequencing (scRNA-seq) to study the connection between cellular heterogeneity and HPV integrations in cervical histopathology. scRNA-seq was used to examine heterogeneity among normal patients and those in three disease stages: high-grade squamous intraepithelial lesions (HSIL), microinvasive carcinoma (MIC), and cervical squamous epithelium carcinoma cancer (CSCC) tissues. A method was developed to identify HPV integration events from scRNA-seq data. Our results indicated an increase in squamous epithelial cells and a decrease in columnar epithelial cells as the disease progressed from normal to CSCC. We discovered HPV genes that were differentially expressed across normal patients and those in the three disease stages. Notably, HPV integration events were more common in squamous epithelial cells at the single-cell level. The ratio of HPV-integrated cells increased as the disease progressed from normal tissue to CSCC, eventually stabilizing. Several genes, such as EGR1, S100A11, S100A8, KRT5, RPL34, ATP1B1, RPS4X and EEF2, were frequently integrated by HPV across patients. In contrast, genes like PAN3, BABAM2, SPEN, TCIM-SIRLNT, TEX41-PABPC1P2 and KCNV1-LINC01608 showed frequent integration events across cells. KRT5, ATP1B1, RPS4X, PAN3 and SPEN were novel recurrent HPV-integrated genes we observed at the patient or cell level in this study. Additionally, we found that HPV genes from various HPV types exhibited integration preferences in various samples and disease stages. This provides a valuable insight into the mechanism of HPV-induced cervical cancer from a single-cell standpoint, highlighting its clinical relevance. - Source: PubMed
Zeng XiPeng FangWang ZiyingTeng QiuliSha YingLeung Ross Ka-KitChristopher L A I Koon ChiLi GuoliangHuang XiaoyuanLin Shitong - Long non-coding RNAs (lncRNAs) have emerged as pivotal regulators in numerous biological processes, including macrophage-mediated inflammatory responses, which play a critical role in the progress of diverse diseases. This study focuses on the regulatory function of lncRNA brain and reproductive organ-expressed protein (BRE) antisense RNA 1 (BRE-AS1) in modulating the inflammatory activation of monocytes/macrophages. Employing the THP-1 cell line as a model, we demonstrate that lipopolysaccharide (LPS) treatment significantly upregulates BRE-AS1 expression. Notably, specific knockdown of BRE-AS1 via siRNA transfection enhances LPS-induced expression of interleukin (IL)-6 and IL-1β, while not affecting tumor necrosis factor (TNF)-α levels. This selective augmentation of pro-inflammatory cytokine production coincides with increased phosphorylation of Janus kinase (JAK)2 and signal transducer and activator of transcription (STAT)3. Furthermore, BRE-AS1 suppression results in the downregulation of suppressor of cytokine signaling (SOCS)3, an established inhibitor of the JAK2/STAT3 pathway. Bioinformatics analysis identified binding sites for miR-30b-5p on both BRE-AS1 and SOCS3 mRNA. Intervention with a miR-30b-5p inhibitor and a synthetic RNA fragment that represents the miR-30b-5p binding site on BRE-AS1 attenuates the pro-inflammatory effects of BRE-AS1 knockdown. Conversely, a miR-30b-5p mimic replicated the BRE-AS1 attenuation outcomes. Our findings elucidate the role of lncRNA BRE-AS1 in modulating inflammatory activation in THP-1 cells via the miR-30b-5p/SOCS3/JAK2/STAT3 signaling pathway, proposing that manipulation of macrophage BRE-AS1 activity may offer a novel therapeutic avenue in diseases characterized by macrophage-driven pathogenesis. - Source: PubMed
Publication date: 2024/10/28
Shin Jae-JoonSuk KyounghoLee Won-Ha