CENPP antibody Polyclonal Antibodies Primary antibodies
- Known as:
- CENPP (anti-) Polyclonal Antibodies Primary antibodies
- Catalog number:
- orb100043
- Product Quantity:
- 100
- Category:
- -
- Supplier:
- Biorb
- Gene target:
- CENPP antibody Polyclonal Antibodies Primary antibodies
Related genes to: CENPP antibody Polyclonal Antibodies Primary antibodies
- Gene:
- CENPP NIH gene
- Name:
- centromere protein P
- Previous symbol:
- -
- Synonyms:
- RP11-19J3.3, CENP-P
- Chromosome:
- 9q22.31
- Locus Type:
- gene with protein product
- Date approved:
- 2006-06-15
- Date modifiied:
- 2014-11-18
Related products to: CENPP antibody Polyclonal Antibodies Primary antibodies
Related articles to: CENPP antibody Polyclonal Antibodies Primary antibodies
- Inflammatory bowel disease (IBD) is a chronic recurrent inflammatory disease, and the treatment of IBD remains a challenge due to its limited therapeutic efficiency, high side effects, and high cost. It has been demonstrated that sporopollenin microcapsules derived from a variety of pollen species could function as efficient drug carriers due to their great thermal stability, resilience to harsh chemicals, homogeneity in size, and biocompatibility. Herein, we engineered a biohybrid nanozyme-based edible sporopollenin system, which can be applied to effectively treat IBD. The biohybrid sporopollenin (CeNP-P) loaded with a cerium oxide nanozyme (CeNP) was encapsulated in microspheres (CeNP-P/MS) by a microfluidic electrospray technique. This micronanosystem protects the CeNP-P from degradation in gastric conditions and enables the rapid release of CeNP-P in the intestine. The released CeNP exhibited the desired anti-inflammatory effects by suppressing pro-inflammatory cytokines and scavenging reactive oxygen species. To explore its practical value, in vivo experiments have been carried out with an IBD mouse model. Compared to the IBD group, the treatment groups displayed significant therapeutic outcomes, particularly the CeNP-P/MS group. Following taking CeNP-P/MS orally, key IBD symptoms were greatly alleviated, as evidenced by the restored colonic morphology, enhanced intestinal barrier integrity, and induced inflammatory responses. Collectively, these findings demonstrate that the present edible system can offer a promising strategy for the effective treatment of intestinal diseases. - Source: PubMed
Publication date: 2025/07/14
Xi PeipeiWei XiangyuHuang YutingWang YunanYang NengjieXu YongxinZhang HaoZhu YujuanGu Zhifeng - High-resolution single-nucleus RNA-sequencing data indicate a clear separation between primary sites of calcium and magnesium handling within distal convoluted tubule (DCT). Both DCT1 and DCT2 express Slc12a3, but these subsegments serve distinctive functions, with more abundant magnesium-handling genes along DCT1 and more calcium-handling genes along DCT2. The data also provide insight into the plasticity of the distal nephron-collecting duct junction, formed from cells of separate embryonic origins. By focusing/changing gradients of gene expression, the DCT can morph into different physiological cell states on demand. - Source: PubMed
Publication date: 2024/01/19
Su Xiao-TongReyes Jeremiah VLackey Anne EDemirci HasanBachmann SebastianMaeoka YujiroCornelius Ryan JMcCormick James AYang Chao-LingJung Hyun JunWelling Paul ANelson Jonathan WEllison David H - Vaccination is still the main method of preventing most infectious diseases, but there are inefficiencies and inaccuracies in immunization. Studies have reported that Atractylodis macrocephalae Koidz. polysaccharides (RAMP) have immunomodulatory effects, but the mechanisms involved in whether they can modulate the immune response in chickens are not yet clear. The aim of this study was to investigate the effect of RAMP on lymphocytes functions by analyzing cell proliferation, cell cycle, mRNA expression of cytokines and CD4 +/CD8 + ratio. To identify potential molecules involved in immune regulation, we performed a comprehensive transcriptome profiling of chicken lymphocytes. In addition, the adjuvant effect of RAMP was evaluated by detecting indicators of hemagglutination inhibition. When lymphocytes were cultured with RAMP in vitro, the proliferation rate of lymphocytes was increased (P < 0.01), more cells in S phase and G2/M phase (P < 0.01) and the mRNA expression of IFN-γ was upregulated (P < 0.05), while the mRNA expression of TGF-β (P < 0.01) and IL-4 (P < 0.05) was downregulated and the CD4 +/CD8 + ratio was increased (P < 0.05). Transcriptomic results showed that RAMP increased the expression of HIST1H46 (P < 0.05) and CENPP (P < 0.05). Validation of qPCR showed that RAMP may play an important role in regulating cellular immunity by downregulating the Notch pathway. The results also showed that RAMP could increase the serum Newcastle disease virus antibody levels in chickens. These data suggest that RAMP could enhance immune function of lymphocytes and was a candidate vaccine adjuvant in chickens. - Source: PubMed
Publication date: 2023/10/11
Hu WeidongHuang KaiyueZhang LiNi JingxuanXu WeiBi Shicheng - Experimental studies suggest that exposures may impact respiratory health across generations via epigenetic changes transmitted specifically through male germ cells. Studies in humans are, however, limited. We aim to identify epigenetic marks in offspring associated with father's preconception smoking. - Source: PubMed
Publication date: 2023/08/31
Kitaba Negusse TadesseKnudsen Gerd Toril MørkveJohannessen AneRezwan Faisal IMalinovschi AndreiOudin AnnaBenediktsdottir BryndisMartino DavidGonzález Francisco Javier CallejasGómez Leopoldo PalaciosHolm MathiasJõgi Nils OskarDharmage Shyamali CSkulstad Svein MagneWatkins Sarah HSuderman MatthewGómez-Real FranciscoSchlünssen ViviSvanes CecilieHolloway John W - Liver cancer is a lethal cancer type among which hepatocellular carcinoma (HCC) is the most common manifestation globally. Drug resistance is a central problem impeding the efficiency of HCC treatment. Long non-coding RNAs reportedly result in drug resistance. This study aimed to identify key lncRNAs associated with doxorubicin resistance and HCC prognosis. HCC samples with gene expression profiles and clinical data were accessed from public databases. We applied differential analysis to identify key lncRNAs that differed between HCC and normal samples and between drug-fast and control samples. We also used univariate Cox regression analysis to screen lncRNAs or genes associated with HCC prognosis. The least absolute shrinkage and selection operator (LASSO) was used to identify the key prognostic genes. Finally, we used receiver operating characteristic analysis to validate the effectiveness of the risk model. The results of this study revealed RNF157-AS1 as a key lncRNA associated with both doxorubicin resistance and HCC prognosis. Metabolic pathways such as fatty acid metabolism and oxidative phosphorylation were enriched in RNF157-AS1-related genes. LASSO identified four protein-coding genes-, , , and -to construct a risk model. The four-gene risk model effectively classified HCC samples into two risk groups with different overall survival. Finally, we established a nomogram, which showed superior performance in predicting the long-term prognosis of HCC. RNF157-AS1 may be involved in doxorubicin resistance and may serve as a potential therapeutic target. The four-gene risk model showed potential for the prediction of HCC prognosis. - Source: PubMed
Publication date: 2022/11/10
Zhang ZunyiChen WeixunLuo ChuZhang Wei