TLR10 pAb
- Known as:
- TLR10 pAb
- Catalog number:
- ASACSA-830E
- Product Quantity:
- 100 µg
- Category:
- -
- Supplier:
- Other suppliers
- Gene target:
- TLR10 pAb
Related genes to: TLR10 pAb
- Gene:
- TLR10 NIH gene
- Name:
- toll like receptor 10
- Previous symbol:
- -
- Synonyms:
- CD290
- Chromosome:
- 4p14
- Locus Type:
- gene with protein product
- Date approved:
- 2001-04-27
- Date modifiied:
- 2016-01-21
Related products to: TLR10 pAb
Related articles to: TLR10 pAb
- Bone regeneration requires tight coordination between mesenchymal stem cells (MSCs), immune signaling, and extracellular matrix remodeling. Yet, how atypical immune receptors contribute to this process remains unclear. Here, we identify Toll-like receptor 10 (TLR10) as a key regulator of osteogenic differentiation in human adipose-derived MSCs. Herein, ASC/TERT1 MSCs were engineered to overexpress or silence TLR10 using lentiviral vectors, and osteogenic differentiation (0-14 days) was assessed by metabolic assays-RT-qPCR of , and -Alizarin Red S staining, and quantitative mass spectrometry. Enhancing TLR10 expression promoted osteogenic gene programs, extracellular matrix organization, metabolic adaptation, and robust matrix mineralization, whereas TLR10 suppression maintained proliferative states and impaired osteoblast maturation. Proteomic analyses revealed that TLR10 selectively activates osteogenic, ECM-remodeling, and vitamin D-responsive pathways, while restraining programs antagonistic to differentiation. Notably, active vitamin D induced TLR10 expression and partially restored osteogenesis in TLR10-deficient cells, indicating that TLR10 is associated with vitamin D-driven bone formation. Together, beyond its established role in innate immunity, TLR10 emerges as a vitamin D-responsive regulator of mesenchymal stem cell osteogenesis, highlighting a potential therapeutic axis to enhance bone regeneration and osteogenic outcomes. - Source: PubMed
Publication date: 2026/04/15
Stierschneider AnnaNeuditschko BenjaminFischer IsabellaHellmann EstherZimmermann DanielProhaska KaterinaMilchram LisaHerzog FranzWiesner Christoph - Inflammation is an important pathogenic factor that leads to thyroid follicular epithelial cells injury after Hashimoto's thyroiditis (HT). Recent studies proposed relationships between pyroptosis and apolipoproteins in HT. However, the molecular signatures involved in the pathophysiological changes that occur during the course of HT remain ambiguous. - Source: PubMed
Publication date: 2026/04/16
Sun BaihuiTan JieYu ShitongGe JunnaWei ZhigangLei ShangtongLi Guoxin - Fungal infections affect over 1.5 billion people, with invasive diseases posing a significant threat to immunocompromised individuals. Toll-like receptors (TLRs) are critical components of innate immunity. Single nucleotide polymorphisms (SNPs) in TLR genes are associated with altered immune responses to fungal infections. - Source: PubMed
Publication date: 2026/04/08
Pereira Staiger Martha Fabiellede Almeida Souza Gleyce HellenVenturini Jamesde Aguiar Peres Nalu TeixeiraLucini FabíolaAssis Santos DanielBastos Rafael WesleyCarvalho AgostinhoRossato Luana - Sex differences in immune responses are partly attributed to sex hormones, with testosterone generally associated with dampened immune responses. However, the specific impact of testosterone on the innate immune system in humans remains unclear. We examined changes in toll-like receptor (TLR) transcript levels and peripheral blood leukocyte parameters during masculinizing hormone therapy in transmasculine individuals. - Source: PubMed
Publication date: 2026/03/18
Cihan HüseyinGüngör ÖzgeKocabas Gökcen ÜnalKöroglu Esma PehlivanGülpinar KübraPariltay ErhanArdeniz ÖmürT'Sjoen GuyLeffler JonatanWinzeler BettinaYürekli Banu Sarer - Bacterial meningitis is a severe disease with a fatality rate of 5-50%. It is mainly caused by or , which can also cause simultaneous infections outside the central nervous system. Toll-like receptors (TLRs) have an important role in the innate immune system. The TLR2 subfamily comprises the four highly homologous members TLR1, TLR2, TLR6, and TLR10, which also have an important immunomodulatory role in infectious diseases. - Source: PubMed
Publication date: 2026/02/25
Teräsjärvi JohannaTenhu ElinaCruzeiro Manuel LeiteSavonius OkkoRugemalira EmilieHe QiushuiPelkonen Tuula