Phospho IRS_1 (Tyr612) pAb
- Known as:
- Phospho IRS_1 (Tyr612) pAb
- Catalog number:
- ASACSA-725E
- Product Quantity:
- 100 µL
- Category:
- -
- Supplier:
- Other suppliers
- Gene target:
- Phospho IRS_1 (Tyr612) pAb
Related genes to: Phospho IRS_1 (Tyr612) pAb
- Gene:
- IL20RB NIH gene
- Name:
- interleukin 20 receptor subunit beta
- Previous symbol:
- FNDC6
- Synonyms:
- DIRS1, IL-20R2, MGC34923
- Chromosome:
- 3q22.3
- Locus Type:
- gene with protein product
- Date approved:
- 2000-05-23
- Date modifiied:
- 2015-12-11
- Gene:
- IRS1 NIH gene
- Name:
- insulin receptor substrate 1
- Previous symbol:
- -
- Synonyms:
- HIRS-1
- Chromosome:
- 2q36.3
- Locus Type:
- gene with protein product
- Date approved:
- 1992-08-24
- Date modifiied:
- 2016-10-05
- Gene:
- KRT71 NIH gene
- Name:
- keratin 71
- Previous symbol:
- -
- Synonyms:
- KRT6IRS, KRT6IRS1, K6IRS1
- Chromosome:
- 12q13.13
- Locus Type:
- gene with protein product
- Date approved:
- 2006-07-17
- Date modifiied:
- 2016-03-09
Related products to: Phospho IRS_1 (Tyr612) pAb
Related articles to: Phospho IRS_1 (Tyr612) pAb
- High-fat diets (HFDs) are a key contributor to obesity and promote oxidative stress and inflammation, which are associated with muscle atrophy and insulin resistance (IR). Passiflora edulis exhibits anti-obesity, antioxidant, and anti-inflammatory effects. The study aimed to investigate the potential benefit of P. edulis f. flavicarpa (PF) extract in preventing obesity-associated muscle atrophy and IR. The PF extract effectively inhibited cholesterol micelle solubility with an IC of 3431 µg/mL and decreased fat accumulation in 3T3-L1 adipocytes. Furthermore, this study investigated a model of HFD-induced IR and muscle atrophy in rats. Thirty-five male Sprague-Dawley (SD) rats were induced with obesity by HFD and were administered 250 and 500 mg/kg/day of PF extract. Rats fed with an HFD were associated with fat accumulation and oxidative stress, which promoted inflammation, muscle damage, muscle atrophy, and IR in obese rats. However, administration of PF extract effectively mitigated these effects. The PF extract decreased fat accumulation in white adipose tissues and gastrocnemius (GAS) muscle by inhibiting fat absorption and synthesis, particularly Cd36 and Hmgcr. The PF extract also notably reduced oxidative stress-induced muscle inflammation and damage via elevating nuclear factor erythroid 2-related factor 2 (Nrf2) and reducing nuclear factor kappa B (NF-κB) expressions. Additionally, PF extract was found to mechanistically prevent muscle atrophy by inhibiting Fbxo32, Trim63, and B-cell lymphoma 2 (BCL2)-associated X (Bax) expressions, while enhancing Bcl2 expression. We also found that PF extract mitigated muscle IR by upregulation of the insulin receptor substrate-1/phosphatidylinositol-3 kinase/protein kinase B (IRS-1/PI3K/AKT) pathway and Slc2a4 expression. The findings indicate that PF extract can prevent skeletal muscle loss and IR in obesity by modulating oxidative stress, inflammation, and activating IRS-1/PI3K/AKT signaling pathway. - Source: PubMed
Chobsuay NraratChonpathompikunlert PennapaSrivilai JukkarinMalakul WachirawadeeLimpeanchob NanteetipAimjongjun SathidTunsophon Sakara - In Uganda, where malaria transmission is high, insecticide treated nets (ITNs) have been distributed nationwide every 3 years since 2013. In West Nile, northern Uganda, indoor residual spraying (IRS) was first implemented with clothianidin-deltamethrin (Fludora Fusion®) in 2022, followed by pirimiphos-methyl (Actellic® 300CS) in 2023. We utilised a quasi-experimental study to assess the impact of IRS + ITNs on malaria incidence in West Nile. - Source: PubMed
Publication date: 2026/05/05
Namuganga Jane FMcDermott Daniel PEpstein AdrienneNankabirwa Joaniter IGonahasa SamuelOpigo JimmyNabende IsaiahMaiteki-Sebuguzi CatherineKamya Moses RDonnelly Martin JDorsey GrantStaedke Sarah G - Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver disease and strongly linked to obesity and insulin resistance. We previously reported that the common nuclear envelope variant rs6461378 (g.842031C>T; H118Y) associated with MASLD and related traits including insulin resistance. To gain insight into how wild-type (WT) and H118Y SUN1 might differentially impact insulin signaling, we performed affinity purification-mass spectrometry (AP-MS) in human liver-derived cells stably expressing WT or H118Y SUN1. Unbiased AP-MS revealed a novel SUN1-CUL3 interaction, with comparative analysis showing that WT SUN1 interacted robustly with CUL3, while CUL3 interaction was markedly diminished with H118Y SUN1. Cells in which was silenced via siRNA, or in which H118Y SUN1 was ectopically expressed, showed increased CUL3 neddylation, which is required for cullin RING ligase (CRL)-mediated ubiquitination of insulin receptor substrate (IRS) proteins. Inhibition of neddylation restored IRS-1 levels and insulin signaling in H118Y SUN1-expressing cells. Together, our findings provide a potential mechanism of H118Y SUN1-driven insulin resistance and a viable therapeutic approach for its reversal. - Source: PubMed
Publication date: 2026/04/20
Upadhyay Kapil KYang YunshuShah ArenBasrur VenkateshaNesvizhskii Alexey IBrady Graham F - The retinal pigment epithelium (RPE) plays a pivotal role in retinal homeostasis and energy metabolism. A recent study demonstrates that RPE cells release insulin in response to photoreceptor outer segment (POS) phagocytosis and starvation conditions. However, the downstream signalling pathway of this local insulin production has not yet been identified. Therefore, using the ARPE-19 cell line as an in vitro model of human RPE, we have investigated insulin signalling in basal conditions and after rod OS phagocytosis. Our data show that ARPE-19 cells express key pancreatic β-cell markers, including the transcription factor Pancreatic and Duodenal Homeobox-1 (PDX-1), which translocates to the nucleus in response to phagocytosis, and prohormone convertase 1/3 (PC1/3). In addition, ARPE-19 cells synthesize and secrete insulin already in basal conditions, increasing their release after phagocytosis. The RPE-secreted insulin acts in an autocrine manner, activating the canonical insulin signalling pathway and leading to increased phosphorylation of insulin receptor (IR), insulin receptor substrate-1 (IRS-1), and AKT. An upregulation of the insulin-responsive glucose transporter GLUT4 and increased glucose uptake was also observed, fueling the ARPE-19 cells' oxidative energy metabolism, incrementing the oxidative phosphorylation activity, probably to sustain the high energy demand associated with phagocytosis. At the same time, a decrease in lactate release has been observed. These features may have important implications for understanding retinal energy metabolism and developing novel therapeutic strategies for retinal neurodegenerative diseases. - Source: PubMed
Publication date: 2026/05/01
Puddu AlessandraBalbi MatildeRavera SilviaPanfoli IsabellaMaggi Davide - Obesity is increasingly recognized as an immunometabolic disorder driven by dysregulated crosstalk between visceral adipose tissue and the liver, particularly along the liver-omentum axis, which promotes insulin resistance and hepatic steatosis. Although Chaihu-Wendan Decoction (CHWD) is effective for metabolic disorders, its molecular mechanisms of action on this inflammatory axis remains unclear. This study aimed to investigate the therapeutic mechanisms of CHWD in high-fat diet (HFD)-induced obesity model, specifically focusing on insulin signaling and immune microenvironment remodeling in the liver-omentum axis. - Source: PubMed
Publication date: 2026/04/15
Ye BinZhou YujieWang YanlingShi QianHuang SiqinYang HaiyanMao BaoxinWang Ping