BMP4 Monoclonal Antibody (clone 6B7)
- Known as:
- BMP4 Monoclonal Antibody (clonality 6B7)
- Catalog number:
- ASA905-834
- Product Quantity:
- 100 µL
- Category:
- -
- Supplier:
- Other suppliers
- Gene target:
- BMP4 Monoclonal Antibody (clone 6B7)
Related genes to: BMP4 Monoclonal Antibody (clone 6B7)
- Gene:
- ATP6V0A2 NIH gene
- Name:
- ATPase H+ transporting V0 subunit a2
- Previous symbol:
- -
- Synonyms:
- TJ6, a2, TJ6s, TJ6M, ATP6a2, J6B7, ATP6N1D, Vph1, Stv1
- Chromosome:
- 12q24.31
- Locus Type:
- gene with protein product
- Date approved:
- 2002-05-09
- Date modifiied:
- 2016-02-11
- Gene:
- BMP4 NIH gene
- Name:
- bone morphogenetic protein 4
- Previous symbol:
- BMP2B
- Synonyms:
- -
- Chromosome:
- 14q22.2
- Locus Type:
- gene with protein product
- Date approved:
- 1990-06-11
- Date modifiied:
- 2016-10-05
- Gene:
- LINC00092 NIH gene
- Name:
- long intergenic non-protein coding RNA 92
- Previous symbol:
- NCRNA00092
- Synonyms:
- bA346B7.1
- Chromosome:
- 9q22.32
- Locus Type:
- RNA, long non-coding
- Date approved:
- 2008-09-03
- Date modifiied:
- 2018-05-18
Related products to: BMP4 Monoclonal Antibody (clone 6B7)
Related articles to: BMP4 Monoclonal Antibody (clone 6B7)
- Metastasis remains the leading cause of mortality in breast cancer, and effective prevention strategies are urgently needed. Sodium ferulate (SF), a bioactive compound derived from ferulic acid, has demonstrated diverse pharmacological activities, yet its role in suppressing cancer metastasis remains unclear. In this study, we demonstrate that SF significantly inhibits breast cancer metastasis through comprehensive modulation of the bloodstream microenvironment. At non-toxic concentrations, SF inhibited the migration and invasion of MCF-7 and MDA-MB-231 cells by suppressing the BMP4/Smad1/5/9 signaling pathway, reversing epithelial-mesenchymal transition (EMT), and disrupting cell cycle progression. SF also enhanced the sensitivity of breast cancer cells to paclitaxel. In addition, SF reduced tumor cell adhesion to endothelial cells by blocking TNF-α-induced expression of ICAM-1 and VCAM-1 through inhibition of NF-κB signaling cascade. Furthermore, SF attenuated platelet activation and angiogenesis, two key processes involved in metastatic dissemination and colonization. In 4T1 mouse metastasis model, SF treatment significantly decreased pulmonary metastatic nodules without causing organ toxicity. Immunohistochemical analysis further confirmed decreased expression of BMP4, PI3K, and N-cadherin in lung tissues following SF treatment. Additionally, SF enhanced systemic immunity by increasing the proportion of cytotoxic T cells and natural killer cells in peripheral blood. Collectively, these findings reveal that SF exerts potent anti-metastatic effects by modulating tumor-bloodstream-immune interactions rather than direct cytotoxicity. By remodeling the bloodstream microenvironment and enhancing immune defense, SF may represent a promising and safe candidate for the prevention of breast cancer metastasis. - Source: PubMed
Publication date: 2026/06/25
Lin MengtingHe ShanshanZhong ChunlianWang WeiyuYao YinyinLuo LinXu JundanMa LeiZhao XinyiFu ChengbinHuang MingqingLu Yusheng - Segmental bone defects and age-related osteoarthritis (OA) are clinically challenging in terms of treatment. Although preclinical studies have demonstrated efficacy for bone defect healing and OA using ex vivo gene therapy or biomaterial sustained-release delivery, few such treatments have translated into clinical therapies due to safety concerns. Bone morphogenetic proteins belong to the transforming growth factor β (TGFβ) superfamily and are effective in bone and cartilage regeneration/repair. Among BMPs, BMP4 is not only effective in promoting bone and cartilage repair but also promotes stem cell renewal potential and exhibits anti-aging effects. Therefore, the aim of this study is to investigate whether human BMP4 mRNA encapsulated in lipid nanoparticles (hBMP4 mRNA/LNP) can promote bone and cartilage repair. In vitro data demonstrated that hBMP4 mRNA/LNP-treated human MSCs secreted BMP4 protein, as detected by ELISA, and enhanced osteogenic differentiation. In vivo results demonstrated that hBMP4 mRNA/LNP at a 50 µg dose promoted limited new bone formation only at 2 weeks after creation of defect in critical-sized calvarial bone defects in aged mice when delivered using fibrin sealant hydrogel, as revealed by micro-CT and histology. However, intra-articular injection (IA) of lower doses (2.5 and 5 µg) in aged mice knee joints prevented cartilage loss, as demonstrated by micro-CT; decreased OARSI histology scores; and improved cartilage-specific matrix COL2. hBMP4 mRNA/LNP at a 5 μg dose significantly increased SOX9 cells per normalized cartilage area as well as the percentage of SOX9 cells in the cartilage area. hBMP4 mRNA/LNP treatment showed a trend of pain alleviation and did not change serum hyaluronic acid levels. In conclusion, human BMP4 mRNA encapsulated in lipid nanoparticles improved cartilage repair and delayed cartilage degeneration in aged mice, while having a limited effect on bone healing, even at a higher dosage. These results suggest that hBMP4 mRNA encapsulated with lipid nanoparticles represents a promising treatment for age-related OA. - Source: PubMed
Publication date: 2026/06/01
Gao XueqinXiao ZuokuiHuard MatthieuNakayama KeisukeCummings ArynForce Britney SLi HongyeMancino ChiaraCooke John PTaraballi FrancescaPhilippon Marc JHuard Johnny - Most rabbit embryonic stem (rbES) cell lines established in embryonic fibroblast feeder layer systems predominantly exhibit pluripotency features restricted to a "primed" state, which hinders their directed differentiation into reproductive germ cells and limits their capacity for germline transmission. - Source: PubMed
Publication date: 2026/06/08
Chen XiaoLiu ZhihuiLi QingUllah RahmanGao YuanWang XiyueLiu LanjunDu Fuliang - Over the past 2 decades, major advances have contributed to the elucidation of the structural and biochemical bases underlying the biological activities attributed to CCN proteins. The concept that CCN proteins exhibit bifunctional "moonlighting" properties in both the extracellular matrix (ECM) and the cell nucleus has recently emerged. CCN proteins participate in dual signaling processes, integrating combinatorial interactions with regulatory ligands, cell surface receptors or associated co-receptors such as heparan sulfate proteoglycans (HSPGs), LRPs, TrkA, Notch, integrins, BMP-4, TGF-β, and FGFR2, as well as transcription factors in the nuclear compartment. In this manuscript, we propose an exploratory integrative model that brings together previously unassociated observations into a coherent framework. In this model, the C-terminal module, present in all CCN proteins except CCN5, is proposed to direct the formation of homo- and heterodimers, which constitute a fundamental level of transcriptional regulation. - Source: PubMed
Publication date: 2026/05/19
Perbal Bernard - The previous study elucidated that the C-reactive protein (CRP)/bone morphogenetic protein 4 (BMP4) signaling pathway mediates periodontitis-associated anxiety-like behaviors in rats. This molecular crosstalk along the periodontal-hippocampal axis provides novel insights into the etiology and mechanisms of emotional disorders. However, several key issues remain to be further discussed regarding the establishment of the core finding linking peripheral inflammation to emotional disorders and potential translational significance. Here, this commentary analyzes the mechanisms underlying CRP entry into the brain, the choice of behavioral paradigms for emotional assessment, the possible dynamic evolution of the pathogenesis, and the translational potential of CRP, with the aim of fostering constructive academic discussion. - Source: PubMed
Publication date: 2026/06/19
Chen ZhigangLi Xing