PGD2 Receptor (DP1) Polyclonal Antibody
- Known as:
- PGD2 Receptor (DP1) Polyclonal Antibody
- Catalog number:
- ASA905-80025
- Product Quantity:
- 25 µg
- Category:
- -
- Supplier:
- Other suppliers
- Gene target:
- PGD2 Receptor (DP1) Polyclonal Antibody
Related genes to: PGD2 Receptor (DP1) Polyclonal Antibody
- Gene:
- AMD1P2 NIH gene
- Name:
- adenosylmethionine decarboxylase 1 pseudogene 2
- Previous symbol:
- AMD2, AMD, AMDP1
- Synonyms:
- AMDPX, AMDPY
- Chromosome:
- Xq28 and Yq12
- Locus Type:
- pseudogene
- Date approved:
- 1988-08-31
- Date modifiied:
- 2015-03-19
- Gene:
- BATF3 NIH gene
- Name:
- basic leucine zipper ATF-like transcription factor 3
- Previous symbol:
- -
- Synonyms:
- JUNDM1, SNFT, JDP1
- Chromosome:
- 1q32.3
- Locus Type:
- gene with protein product
- Date approved:
- 2007-10-17
- Date modifiied:
- 2016-06-28
- Gene:
- C2CD5 NIH gene
- Name:
- C2 calcium dependent domain containing 5
- Previous symbol:
- KIAA0528
- Synonyms:
- CDP138
- Chromosome:
- 12p12.1
- Locus Type:
- gene with protein product
- Date approved:
- 2006-01-17
- Date modifiied:
- 2016-06-08
- Gene:
- CFAP221 NIH gene
- Name:
- cilia and flagella associated protein 221
- Previous symbol:
- -
- Synonyms:
- FAP221, PCDP1
- Chromosome:
- 2q14.2
- Locus Type:
- gene with protein product
- Date approved:
- 2014-07-03
- Date modifiied:
- 2016-04-25
- Gene:
- CNNM1 NIH gene
- Name:
- cyclin and CBS domain divalent metal cation transport mediator 1
- Previous symbol:
- ACDP1
- Synonyms:
- -
- Chromosome:
- 10q24.2
- Locus Type:
- gene with protein product
- Date approved:
- 1999-12-07
- Date modifiied:
- 2015-08-28
Related products to: PGD2 Receptor (DP1) Polyclonal Antibody
Related articles to: PGD2 Receptor (DP1) Polyclonal Antibody
- Phthalate plasticizers, especially diethyl phthalate (DEP), are linked to metabolic disorders, while their precise role and mechanism in diabetic nephropathy (DN) pathogenesis remain unclear. Here, we integrated transcriptomic bioinformatics, machine learning, molecular docking, and in vitro validation to decipher the nephrotoxic effect of DEP and its primary metabolite monoethyl phthalate (MEP) on DN. We found that common phthalate targets were significantly enriched in unsaturated fatty acid metabolism, prostaglandin synthesis, and prolactin signaling pathways. Fourteen core genes were screened, among which lymphocyte-specific protein tyrosine kinase (LCK) and hematopoietic prostaglandin D synthase (HPGDS) showed robust diagnostic potential for DN. Molecular docking revealed stable binding of phthalates to signal transducer and activator of transcription 3 (STAT3). In HK-2 renal tubular epithelial cells, DEP/MEP exposure reduced cell viability in a dose-dependent manner, activated the STAT3/transforming growth factor-beta 1 (TGF-β1) axis, and induced apoptosis, which were partially reversed by STAT3 inhibition. Collectively, environmental phthalate exposure exacerbates DN progression via disrupting lipid metabolism, activating inflammatory signaling, and promoting renal cell apoptosis, with LCK and HPGDS as promising diagnostic biomarkers for DN. - Source: PubMed
Publication date: 2026/04/10
Li ChangYanZhang LeShi LuYaoMa JingYuanFan WenXing - Individuals with prediabetes or diabetes face elevated dementia risk, yet robust prediction tools and mechanistic insights remain limited. - Source: PubMed
Publication date: 2026/03/15
Zhang YuanyuanHuang YuXue JunyuZhang YiweiYang SisiZhang YanjunYe ZiliangGan XiaoqinWu YitingHou FanfanQin Xianhui - Buckwheat (BW) is recognized as a functional food with antioxidant and anti-inflammatory properties. BW (poly)phenols are important bioactive compounds associated with these benefits, although their therapeutic role remains elusive. We used a multidisciplinary approach to identify the bioactive flavonoids of BW and their molecular mechanisms. Physiologically relevant concentrations of luteolin (Lute), quercetin (Quer), apigenin (Api), and kaempferol (Kaem) were effective in reducing prostaglandin (PG)E and PGD biosynthesis in LPS-activated macrophages by acting at distinct branch points of the LPS/COX-2 pathway. Lute, Api, and Kaem reduced COX-2 levels, whereas Quer exerted the opposite effect. Lute and Kaem inhibited Ikkβ phosphorylation, while TLR4 was identified as a flavonoid's target. PGE and PGD reductions were independent of COX-2 modulation and correlated with hematopoietic prostaglandin D synthase (hPGDS) inhibition (exerted by Lute and Quer). These findings offer a new perspective on the LPS/COX-2 pathway as a target of BW-derived products to address inflammation-related diseases. - Source: PubMed
Publication date: 2026/03/13
López-Cánovas Diego JoséVico-Padilla AntonioZielińska DanutaPoveda-Lora SabrinaNavarro-Orcajada SilviaLópez-Martínez DavidGarcía-Moreno DianaÁvila-Gálvez María ÁngelesGaray-Mayol BeatrizYuste José EVallejo FernandoEspín Juan CarlosGonzález-Sarrías AntonioZielinski HenrykGiménez-Bastida Juan Antonio - Physical activity (PA) and sedentary behavior (SB) are associated with many diseases, including Alzheimer's disease and all-cause dementia. However, the specific biological mechanisms through which PA protects against disease are not entirely understood. This study aims to address this gap, with a specific focus on all-cause dementia. - Source: PubMed
Publication date: 2026/01/26
Arani GayatriArora AmitYang ShuaiWu JingyueKraszewski Jennifer NMartins AmyMiller AlexandraZeba ZebunnesaJafri AyanHu ChengchengFarland Leslie VBea Jennifer WColetta Dawn KAslan Daniel HSayre M KatherineBharadwaj Pradyumna KAlly MadelineMaltagliati SilvioLai Mark H CWilcox Randde Geus EcoAlexander Gene ERaichlen David AKlimentidis Yann C - Enhancing feed efficiency is central to improving both the economic viability and environmental sustainability of poultry production. Although previous research has documented how intestinal, hepatic, and muscular nutrient metabolism contributes to feed efficiency variation, less is known about corresponding differences in circulating blood. Residual feed intake (RFI) was measured in small-sized meat ducks from 21 to 42 days of age. From a natural population of 800 ducks, the eight individuals with the highest RFI and the eight with the lowest RFI were selected to form the low RFI (LRFI, RFI = -14.95) and high RFI (HRFI, RFI = 11.72) groups, respectively. Blood samples were collected at 21 days of age for plasma biochemical analysis, metabolomic profiling, and whole-blood transcriptomic analysis. Plasma biochemical analyses showed that LRFI ducks exhibited significantly reduced triglyceride (TG) concentrations and significantly elevated glucose (GLU) and creatine kinase (CK) levels relative to HRFI birds (P < 0.05). Metabolomic profiling further revealed significant suppression of the arachidonic acid and α-linolenic acid metabolic pathways in LRFI ducks (P < 0.05). Weighted gene co-expression network analysis (WGCNA) combined with protein-protein interaction analysis identified HLX, CSF1R, MECR, RICTOR, and HTT as core genes associated with RFI, based on their network connectivity, differential expression patterns between HRFI and LRFI ducks, and evidence of selection signals (P < 0.05). Integrated metabolomic-transcriptomic analyses further highlighted key blood-based indicators linked to RFI within the arachidonic acid pathway, including metabolites (PC-O, prostaglandin G2, thromboxane B2, and 5-oxo-ETE) and genes (GGT1, HPGDS, and LCN2), which may serve as early predictive markers for selecting LRFI ducks. Collectively, these results provide a systematic characterization of blood metabolic and transcriptional differences between ducks with divergent RFI and identify potential early blood-based biomarkers that may support the genetic improvement of feed efficiency in poultry. - Source: PubMed
Publication date: 2026/01/18
Zhuang ZhongLi YongpengLu YijiaBai HaoBi YulinWang ZhixiuChen ShihaoChang GuobinJiang Yong