Human Factor VIIa 1mg
- Known as:
- Human Factor VIIa 1mg
- Catalog number:
- IHFVIIa -1mg
- Product Quantity:
- 1mg
- Category:
- -
- Supplier:
- Innovative
- Gene target:
- Human Factor VIIa 1mg
Related genes to: Human Factor VIIa 1mg
- Gene:
- COX7A2 NIH gene
- Name:
- cytochrome c oxidase subunit 7A2
- Previous symbol:
- -
- Synonyms:
- COXVIIa-L, COX7AL
- Chromosome:
- 6q14.1
- Locus Type:
- gene with protein product
- Date approved:
- 1992-11-25
- Date modifiied:
- 2016-04-25
Related products to: Human Factor VIIa 1mg
Related articles to: Human Factor VIIa 1mg
- The A2 β-casein variant has gained considerable interest in the dairy industry due to proposed health-related benefits, leading to an increasing frequency of the A2A2 genotype in dairy herds. Although the A1/A2 substitution in the β-casein gene (CSN2) does not directly affect gene regulation, previous transcriptomic studies have reported differences in mRNA isoform expression between A1A1 and A2A2 cows. Therefore, the objective of this study was to identify single nucleotide variants (SNVs) in A1A1 and A2A2 β-casein groups of cows using milk fat globule (MFG) RNA-seq data and to evaluate their predicted functional consequences. RNA sequencing was performed on MFG samples obtained from 14 lactating Holstein cows (A1A1, n = 7; A2A2, n = 7). Variants were classified according to their predicted effects as amino acid changing (AAC) variants, splice site effect (SSE) variants, or variants presenting both consequences. Additionally, variant data were integrated with previously reported mRNA isoform expression results, and only variants located in genes showing expression levels ≥ 0.2 FPKM were retained for further analysis. Candidate RNA-seq-derived variants differing between A1A1 and A2A2 β-casein genotype groups were identified in genes involved in mammary gland function and lactation, including mitochondrial function, lipid metabolism, vesicle trafficking and secretion, and RNA processing. Among the prioritized genes, A1A1 cows showed a greater representation of SNVs located in genes involved in mitochondrial oxidative phosphorylation (NDUFV2, NDUFAB1, COX7A2, and ATP5PF), while additional SNVs were identified in lipid metabolism-related genes (ACSL1, ATP10A, and MFGE8). In contrast, A2A2 group of cows showed a greater representation of SNVs located in genes involved in lipid metabolism (LPIN1, FASN, SPTLC2, and ATP11B) and vesicle trafficking and secretion (SEC31A, LRRK2, DBNL, EIPR1, and ABCG2). Overall, these findings provide additional insight into the molecular differences detected between A1A1 and A2A2 groups of cows. Although the predicted functional consequences of the identified variants are currently based on in silico analyses, the novel SNVs reported here constitute a valuable resource for future studies investigating the biological consequences associated with selection for the A2A2 β-casein genotype in Holstein dairy cattle. - Source: PubMed
Jiménez-Montenegro LucíaUrrutia OlaiaCánovas Ángela - Previous pulmonary tuberculosis (TB) is a known risk factor for lung cancer. Earlier studies have demonstrated that tuberculous pleural effusion (TPE)-derived exosomal miRNAs are involved in lung cancer progression. This study aimed to identify potential miRNA-mRNA regulatory pathways contributing to the pathogenesis of TB-associated lung cancer. - Source: PubMed
Publication date: 2026/05/29
Park GoeunKang Hyun-JungHong YoonkiLee Jae JunShin Seung-HoHong Ji Young - Coronary artery disease (CAD) causes irreversible myocardial dysfunction and progressive heart failure due to loss of contractile function and limited endogenous regenerative capacity. Current therapeutic strategies fail to restore lost myocardium or regenerate damaged cardiac tissue. Identifying dysregulated contractility-related genes may reveal actionable targets for stem cell engineering, iPSC-derived cardiomyocyte design, and tissue regeneration aimed at restoring myocardial contractility and function. - Source: PubMed
Publication date: 2026/03/31
Qu FangzhouAn XifengLei YaqiLu ChongLiu HanxiuMa HuayanLi Yongle - Tuberculosis (TB) remains a major cause of infectious disease mortality. Early diagnosis is crucial for curbing transmission and initiating timely treatment. However, the lack of reliable non-sputum-based diagnostic tools often delays prompt detection. Since mitochondrial dysregulation facilitates Mycobacterium tuberculosis (MTB) evasion, we explored mitochondria-related gene signatures as diagnostic biomarkers. By integrating microarray (GSE19491) and single-cell RNA sequencing (scRNA-seq; SRP247583) data from active tuberculosis disease (TBD), latent tuberculosis infection (TBI), and healthy controls (HC) obtained from the Gene Expression Omnibus (GEO) database, we identified ten mitochondria-related differentially expressed genes (MitoDEGs) -STAT2, CASP1, SCO2, PRELID1, COX7B, COX6A1, TSPO, IFI6, ATG3, and COX7A2- in the monocytic lineage. Enrichment analysis revealed that these ten MitoDEGs were primarily enriched in oxidative phosphorylation. Quantitative PCR (qPCR) validated the upregulation of these genes in an H37Rv-infected THP-1 cell model (P < 0.01). Using the Least Absolute Shrinkage and Selection Operator (LASSO) and Support Vector Machine-Recursive Feature Elimination (SVM-RFE) algorithms, we prioritized three hub markers (STAT2, CASP1 and COX7B) to construct a blood-based diagnostic model. The SVM-based model achieved robust diagnostic performance in differentiating TBD in the training (n = 125; AUC = 0.852), validation (n = 30; AUC = 0.885), and two testing sets: GSE54992 (n = 15; AUC = 0.907) and GSE34608 (n = 26; AUC = 0.993). Moreover, an independent clinical cohort further confirmed its efficacy (n = 52; AUC = 0.909) in discriminating TBD from non-TB controls. In summary, we developed a three-MitoDEG model that shows promising diagnostic performance for TBD and was preliminarily validated, offering a scalable, non-sputum alternative for triage in resource-limited settings. - Source: PubMed
Publication date: 2026/04/10
Zhang XianyiZhang KehongWang YuZhang BaozhuHuang ZhenXu Yuzhong - Around 15-50% of patients with dMMR/MSI-H metastatic colorectal cancer (mCRC) experience primary and secondary resistance to immune checkpoint inhibitors (ICI). We previously described three transcriptomic clusters (A, B, C) linked to progression-free survival (PFS), with cluster A ("Stromal - Proliferation) associated with the shortest PFS. Here we combine gene signature and mucinous phenotype to predict the benefit from anti-CTLA-4 plus anti-PD-1. - Source: PubMed
Publication date: 2026/04/05
Ambrosini MargheritaGallois ClaireGandini AnnaliceLecanu AurélieAlouani EmilyPietrantonio FilippoBergamo FrancescaCremolini ChiaraMazard ThibaultTougeron DavidGuimbaud RosineLonardi SaraSelves JanickMouillet-Richard SophieEmile Jean-FrancoisTaieb JulienLaurent-Puig Pierre