Mouse Monoclonal to Mouse PAI1 1mg
- Known as:
- Mouse Monoclonal Mouse PAI1 1mg
- Catalog number:
- IH34G6-1mg
- Product Quantity:
- 1mg
- Category:
- -
- Supplier:
- Innovative
- Gene target:
- Mouse Monoclonal PAI1 1mg
Related genes to: Mouse Monoclonal to Mouse PAI1 1mg
- Gene:
- SERPINE1 NIH gene
- Name:
- serpin family E member 1
- Previous symbol:
- PLANH1, PAI1
- Synonyms:
- PAI
- Chromosome:
- 7q22.1
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2019-04-23
Related products to: Mouse Monoclonal to Mouse PAI1 1mg
Related articles to: Mouse Monoclonal to Mouse PAI1 1mg
- Alzheimer's disease (AD) is a prevalent, chronic, and progressive neurodegenerative disorder that predominantly affects the elderly population, and no effective pharmacological treatments are currently available. Histone deacetylase 6 (HDAC6) is overexpressed in the hippocampus of AD patients, and its inhibition has been shown to clear amyloid-β (Aβ) deposits, promote tau protein degradation, ameliorate mitochondrial transport deficits, and restore α-tubulin acetylation. Thus, selective HDAC6 inhibition represents a promising therapeutic strategy for AD, yet the underlying mechanisms by which HDAC6 inhibitors ameliorate cognitive impairment in AD remain elusive. In our previous study, a series of novel imidazo[1,2-a]pyridine-based HDAC6 inhibitors were developed, among which compound a17 exhibited potent HDAC6 inhibitory activity with an IC value of 7.51 nM, warranting further investigation into its anti-AD effects. Herein, we demonstrated that a17 exerted robust neuroprotective effects against L-Glutamate (L-Glu-)/Aβ-induced HT22 cell injury. Additionally, a17 displayed favorable blood-brain barrier (BBB) permeability in vitro and drug-likeness properties. In vivo studies revealed that a17 significantly attenuated AD-like phenotypes in an Aluminium chloride (AlCl)-induced zebrafish AD model, a mechanism potentially associated with the differential regulation of ODC1, Serpine1, and PAG-1. Furthermore, a17 markedly improved scopolamine-induced memory deficits in mice. Collectively, these findings indicate that an HDAC6 inhibitor, a17, was found to attenuate AD-associated pathological and behavioral markers by regulating the expression of ODC1, Serpine1, or PAG-1. Accordingly, a17 merit consideration for a pharmacological treatment of choice for AD. - Source: PubMed
Publication date: 2026/09/05
Han ZheLiu WenminFu WenlingWang KerenTan ZhenghuaiZhang DongweiYang FeifeiDong WuSang Zhipei - Macrophage heterogeneity is increasingly recognized as an important feature of the gastric cancer tumor microenvironment, yet the macrophage states linked to poor outcome and the molecules connecting them to stromal remodeling remain incompletely defined. Here, we integrated single-cell RNA sequencing data from GSE183904, spatial transcriptomic data from GSE251950, and TCGA-STAD bulk transcriptomic data to characterize macrophage diversity and identify clinically relevant macrophage-associated genes. Cell-cell communication analysis revealed intensified intercellular signaling in tumors, with prominent changes in MIF, COLLAGEN, FN1, LAMININ, and SPP1 pathways. Five macrophage subclusters were resolved. Among them, macro_SPP1 and macro_IL1B signatures were associated with shorter overall survival, whereas macro_C3_CX3CR1 was linked to a more favorable outcome. By integrating macro_SPP1 markers with tumor-associated differentially expressed genes and applying Cox regression together with multiple machine learning approaches, SERPINE1 emerged as the most consistent prognostic candidate. High SERPINE1 expression was associated with poor survival and with stromal, myeloid, and vascular features. Spatial analysis further localized SERPINE1-high regions to microenvironments enriched for fibroblast- and endothelial-related components and for TGF-β, hypoxia, inflammatory, and extracellular matrix remodeling programs. Virtual perturbation suggested that SERPINE1 may influence myeloid and matrix-related transcriptional networks. Functionally, SERPINE1 knockdown reduced proliferation, colony formation, migration, and invasion in gastric cancer cells. Together, these findings identify SERPINE1 as a macro_SPP1-associated molecule with prognostic and functional relevance and suggest a potential link between macrophage-associated programs, stromal remodeling, and malignant behavior in gastric cancer. - Source: PubMed
Yu HuangdaoWu JianhaiHong QingqiLin HexinLi YongwenChen DonghanWang HaibinChen YifuYou JunChen Yinan - The pathological mechanism of post-intracerebral hemorrhage (ICH) brain injury remains incompletely clarified. This study aims to clarify the role and molecular mechanism of miR-642b-3p in ICH, thereby providing a potential candidate target for clinical treatment. - Source: PubMed
Publication date: 2026/09/04
Rao ZhijuanLi Jiarong - Glutamic-Pyruvic Transaminase 2 (GPT2) significantly contributes to the advancement of colorectal cancer (CRC). This study aimed to elucidate the expression patterns, functional significance, and underlying mechanisms of GPT2 in CRC. Data from the TCGA repository, supplemented by immunohistochemical analysis, showed that GPT2 is substantially overexpressed in CRC specimens relative to adjacent non-cancerous tissues. This elevated expression level was further correlated with poorer clinical prognosis in patients. Cellular investigations using qPCR and Western blotting revealed differential GPT2 expression across CRC cell lines, with notably high levels in SW620 cells and minimal expression in SW1417 cells. Functional assays revealed that GPT2 overexpression in SW1417 cells notably increased their proliferation, migration, and invasion, while extending the G0/G1 cell cycle phase. Conversely, knocking down GPT2 in SW620 cells suppressed these malignant phenotypes and induced G2/M phase arrest. To investigate the molecular basis, RNA sequencing was performed on GPT2-knockdown SW620 cells, identifying 1020 differentially expressed genes. Enrichment analyses based on GO and the KEGG indicated that the identified genes are predominantly associated with biological processes related to the regulation of blood coagulation and functions localized within the endoplasmic reticulum lumen. Analysis of the PPI network for differentially expressed genes identified five core candidate genes: SERPINE1, CDKN1A, GADD45A, EPHA2, and ASNS. qPCR confirmed the expression levels of these genes, demonstrating a positive correlation with GPT2 expression. In conclusion, GPT2 acts as an oncogenic driver in colorectal cancer, enhancing tumor cell proliferation, migration, and invasive capabilities. This effect is likely mediated through the regulation of downstream targets, including SERPINE1 and CDKN1A. These findings suggest that GPT2 holds potential as both a prognostic indicator and a therapeutic target in colorectal cancer. - Source: PubMed
Publication date: 2026/08/28
Xu XiulianXie PingGan HailinHuang YimingLiu ZhihengLv Qijun - Congenital bronchopleural fistula is an exceptionally rare cause of persistent neonatal air leakage. Most bronchopleural fistulas in newborns are related to mechanical ventilation, infection, or iatrogenic injury. The clinical presentation can suggest pneumothorax commonly seen in premature infants, diagnosis is often delayed, and an ongoing uncontrolled air leak may significantly compromise effective ventilation. - Source: PubMed
Publication date: 2026/08/19
Janowicz TomaszSzostawicki Michał