MSH6 Concentrated Mouse Monoclonal Antibodies;
- Known as:
- MSH6 Concentrated Mouse Monoclonal Antibodies;
- Catalog number:
- Mob 429-05
- Product Quantity:
- 0.5ml
- Category:
- -
- Supplier:
- Diagnostic Biosystems
- Gene target:
- MSH6 Concentrated Mouse Monoclonal Antibodies;
Related genes to: MSH6 Concentrated Mouse Monoclonal Antibodies;
- Gene:
- MSH6 NIH gene
- Name:
- mutS homolog 6
- Previous symbol:
- GTBP
- Synonyms:
- -
- Chromosome:
- 2p16.3
- Locus Type:
- gene with protein product
- Date approved:
- 1995-08-29
- Date modifiied:
- 2019-04-23
Related products to: MSH6 Concentrated Mouse Monoclonal Antibodies;
Related articles to: MSH6 Concentrated Mouse Monoclonal Antibodies;
- Pathogenic germline variant (PGV) rates in cancer risk genes and their association with clinicopathologic features inform genetic testing practices for patients with prostate cancer (PCa). In this study, we determined the rate of PGVs in PCa risk genes in a real-world, diverse cohort of patients with PCa and identified clinical predictors of carrier status. - Source: PubMed
Publication date: 2026/06/02
Crawford Taylor BTayeb MalihaBarrett EmanuelAl-Saleem TaraKondam PranaviHausler RyanSymecko HeatherOrr CaitlinWolfe Catherine SpielmanMann DerekSpielman KelseyWong GloriaHaas Naomi BNarayan VivekRobinson KyleTakvorian SamuelWong Yu-NingSokolova Alexandra OMontgomery Robert BMenendez CarolynKelley Michael JAiello Lisa BGarraway Isla PDomchek Susan MMaxwell Kara N - Lynch syndrome (LS) is an inherited cancer predisposition syndrome associated with an increased risk of several malignancies, particularly colorectal cancer (CRC). The diagnosis of LS is typically based on family history and confirmed by genetic testing, most commonly involving pathogenic variants in mismatch repair genes, including , , , and . We report a proband who developed CRC at the age of 52 years and had a family history suggestive of LS. Immunohistochemical analysis revealed loss of MLH1 and PMS2 expression in the proband, and isolated loss of PMS2 expression in his maternal cousin. Whole-exome sequencing followed by Sanger sequencing identified a heterozygous c.1652A>C (p.Asn551Thr) variant in the proband, his maternal cousin, and four additional affected family members. Based on the clinical, pathological, and genetic findings, the extended family was diagnosed with LS. Taken together, c.1652A>C (p.N551T) variant may contribute to carcinogenesis, and its co-segregation with LS in this family provides supportive evidence for its potential pathogenicity. - Source: PubMed
Publication date: 2026/04/20
Duan ZhipeiHu ChengruCao TinghuaChen ChaoLi Yan - Since 2020, the UK National Institute for Health and Care Excellence (NICE) recommends screening for Lynch syndrome in all people newly diagnosed with endometrial cancer. Screening involves tumour testing for loss of the mismatch repair (MMR) proteins using immunohistochemistry (IHC), methylation testing and germline sequencing for Lynch syndrome according to a diagnostic algorithm. Here we review adherence to NICE guidance at a gynaecological cancer centre in North-West England. - Source: PubMed
Publication date: 2026/05/28
Johnson Jean-EllenMilliken SarahBolton JamesEvans D GarethLalloo FionaDavidson Emma J - Ovarian aging, marked by the gradual decline in both the number and quality of oocytes, significantly impacts women's reproductive lifespan and overall health. However, the biological mechanisms driving ovarian aging remain poorly understood and current treatment strategies are limited. - Source: PubMed
Publication date: 2026/05/28
Lian XuanSong ShuangLou ChenZhu MingLi YanLi WenjianJiang XintongWang GuiquanYang HaiyanWang LinHe LiyingMa YunlongDong XiChen YijieChang Hsun-MingZhu WenchengWang JiaYu YangWu YangZhao YueMu Liangshan - To investigate oncological and reproductive outcomes in patients with mismatch repair-deficient (MMRd) endometrial endometrioid carcinoma (EEC) or atypical endometrial hyperplasia (AEH) undergoing fertility-preserving treatment to inform clinical management of this molecular subtype. - Source: PubMed
Publication date: 2026/05/27
Zhang TianyuYang JieCao DongyanYu MeiWu HuanwenXiang YangZhang XinyueZong XuanZhang RundongJin XinyangZhang KezhenZheng JingYang Jiaxin