Proteins CRISP-2, Human
- Known as:
- Proteins CRISP-2, Human
- Catalog number:
- C596
- Product Quantity:
- 10μg
- Category:
- -
- Supplier:
- Novoprotein
- Gene target:
- Proteins CRISP-2 Human
Related genes to: Proteins CRISP-2, Human
- Gene:
- CRISP2 NIH gene
- Name:
- cysteine rich secretory protein 2
- Previous symbol:
- GAPDL5, TPX1
- Synonyms:
- CRISP-2, CT36
- Chromosome:
- 6p12.3
- Locus Type:
- gene with protein product
- Date approved:
- 1989-10-20
- Date modifiied:
- 2016-01-28
- Gene:
- CRISPLD2 NIH gene
- Name:
- cysteine rich secretory protein LCCL domain containing 2
- Previous symbol:
- LCRISP2
- Synonyms:
- DKFZP434B044, LGL1
- Chromosome:
- 16q24.1
- Locus Type:
- gene with protein product
- Date approved:
- 2005-02-11
- Date modifiied:
- 2016-11-01
Related products to: Proteins CRISP-2, Human
Related articles to: Proteins CRISP-2, Human
- The maturation and motility of epididymal sperm (ES) cells are largely driven by changes in protein expression. This study aimed to analyze the proteomic profile of canine () ES across groups characterized by different progressive motility (PMOT) values to identify motility-related sperm proteins (MRSPs). ES were obtained from the epididymal semen of 19 dogs. The motility and movement parameters of ejaculated sperm (ES) were evaluated using computer-assisted semen analysis (CASA). Samples were classified into two groups: good sperm motility (GSM), defined as PMOT% ≥ 55%, and poor sperm motility (PSM), defined as PMOT < 55%. Principal component analysis (PCA) of the first two components could explain 88.1% of the total variance between the GSM and PSM groups. Protein profiling of ES was performed using NanoUPLC-Q-TOF/MS. Significant statistical differences were demonstrated between the GSM and PSM groups for the TMOT ( = 0.039) and PMOT ( < 0.001). For five common proteins, their abundance was estimated to be higher in the GSM group than in the PSM group: ACTB ( = 0.2732), CRISP2 ( = 0.1558), LTF ( = 0.2661) and significantly higher: ce10 ( = 0.009) and NPC2 ( < 0.0044). These findings may be used to develop diagnostic MRSP-based tests related to ES quality in assisted reproduction techniques in dogs. - Source: PubMed
Publication date: 2026/01/04
Mogielnicka-Brzozowska MarzenaCichowska-Likszo Aleksandra WiktoriaLikszo PawelFraser LeylandPopielarczyk WeronikaPieklik JuliaKamińska MajaLuvoni Gaia Cecilia - EPOS 2020 defined chronic rhinosinusitis (CRS) disease control using patient symptoms and medication usage but endoscopic findings were considered optional. The effect of adding endoscopic features, an appropriate threshold, and their association with present or future symptom control have not been studied. - Source: PubMed
Publication date: 2025/12/19
Liao Steven Chun-KangAgarwal AditiBai JunqinLuo ZhidiDong SiyuanHarmon Regan LGleason Brooke NHuang JuliaConley David BWelch Kevin CShintani-Smith StephanieKern Robert CKato AtsushiMuhammad Lutfiyya NTan Bruce K - The long-term immunological effects of prior Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection in people living with Human Immunodeficiency Virus (HIV) remain poorly understood. This study aimed to characterize plasma proteomic alterations associated with previous SARS-CoV-2 infection in HIV-infected individuals and to identify potential biomarkers and affected pathways. High-throughput liquid chromatography–tandem mass spectrometry (LC–MS/MS) was performed on plasma obtained from three groups: HIV-infected individuals with documented prior SARS-CoV-2 infection, HIV-monoinfected individuals, and healthy controls. A total of 13,675 proteins were identified. Hierarchical clustering and sparse partial least squares discriminant analysis revealed distinct proteomic profiles in the prior-SARS-CoV-2 group. Ten proteins with the highest discriminatory power—PRR11, TEX14, METTL9, NMD3, PXT1, CRISP2, MELK, SPF27, GCP6, and GTPBP8—were associated with cell cycle regulation, RNA processing, apoptosis, mitochondrial function, and cytoskeletal organization. Subcellular localization indicated predominant nuclear and cytoplasmic involvement, suggesting alterations in transcriptional regulation and intracellular structural dynamics. These signatures imply that preceding SARS-CoV-2 exposure may compound HIV-associated immune dysregulation and disrupt cellular homeostasis. The findings offer novel molecular insights into the persistent biological impact of SARS-CoV-2 in the context of HIV and identify candidate proteomic biomarkers with potential utility for risk stratification and targeted intervention in immunocompromised populations. - Source: PubMed
Publication date: 2025/12/09
Chanthara ChayaninKhattiya JanyaRoytrakul SittirukAkekawatchai ChareepornPhaonakrop NarumonNiyomdecha Nattamon - Polyp recurrence (PR) can occur in patients with chronic rhinosinusitis with nasal polyps (CRSwNP) following endoscopic sinus surgery (ESS). We previously constructed a PR prediction model incorporating tissue biomarkers, including eosinophil cationic protein (ECP), IL-5, and anti-double-stranded DNA IgG, as well as clinical variables including the pre-ESS modified Lund-Mackay radiographic score and asthma status. - Source: PubMed
Publication date: 2025/11/12
Bai JunqinMuhammad Lutfiyya NAgarwal AditiHuang JuliaPrice Caroline P EHarmon ReganOka AikoKidoguchi MasanoriKim Joo-HeeLuo ZhidiDong SiyuanLiao Chun-KangGleason BrookeStevens Whitney WConley David BWelch Kevin CSmith Stephanie SPeters Anju TSchleimer Robert PKern Robert CKato AtsushiTan Bruce K - In acute ischemic stroke, infarcted tissue gradually becomes detectable on noncontrast computed tomography (NCCT) as a hypodensity representing vasogenic edema. We studied whether subtle NCCT density changes are also present in penumbral tissue. - Source: PubMed
Publication date: 2025/06/25
Vandewalle LieselotteKonduri Praneeta RChristensen SorenSeners PierreWouters AnkeYuen NicoleMlynash MichaelKemp StephanieHeit Jeremy JAlbers Gregory WDemeestere JelleLansberg Maarten GLemmens Robin