Proteins CRHBP, Human
- Known as:
- Proteins CRHBP, Human
- Catalog number:
- C595
- Product Quantity:
- 10μg
- Category:
- -
- Supplier:
- Novoprotein
- Gene target:
- Proteins CRHBP Human
Related genes to: Proteins CRHBP, Human
- Gene:
- CRHBP NIH gene
- Name:
- corticotropin releasing hormone binding protein
- Previous symbol:
- -
- Synonyms:
- CRF-BP, CRFBP
- Chromosome:
- 5q13.3
- Locus Type:
- gene with protein product
- Date approved:
- 1991-08-07
- Date modifiied:
- 2014-12-19
Related products to: Proteins CRHBP, Human
Related articles to: Proteins CRHBP, Human
- The heterogeneity in health effects of circulating proteins remained unclear. Previous studies have identified that glycoprotein acetyls (GlycA), a stable biomarker of inflammation, were associated with risks of mortality and chronic diseases. However, it remained unclear whether the health risks of proteins may differ across people with varied GlycA levels. Based on the multi-omics profiling of the UK Biobank prospective cohort, we evaluated whether GlycA statistically modifies the protein-mortality associations. In the discovery dataset (n = 24,134), we observed that GlycA significantly modified the associations of ANG, CRHBP, CXCL16, and PRRT3 with all-cause mortality, and these findings were replicated in the validation dataset (n = 6081). Subgroup analyses further indicated that associations between these proteins and mortality can be modulated by GlycA levels. Through exploratory analyses focused on chronic diseases and cause-specific mortality, we identified that cross-products of GlycA with these proteins can be associated with cancer mortality and heart failure. Together, the findings will expand our understanding of heterogeneity in protein-health associations and highlight several potential therapeutic targets for interventions across people with varied inflammation status. - Source: PubMed
Wang XinruQiao ZiyanTao ChengzheLiao SijingLi ZhiXu QiaoqiaoFan YunWang YufengHan YanDai XiuliangLu Chuncheng - Bighead carp () is a key aquaculture species, with the head and its orbital fat being a commercially valuable product. To elucidate the molecular basis of growth variation, we performed comparative transcriptome analysis of orbital fat from extreme growth phenotypes at juvenile (6 months) and market-size (18 months) stages. In juveniles, slow growth was linked to upregulation of stress-responsive genes (, , ), while fast growth correlated with higher expression of stress-buffering () and nutrient-signaling (, ) genes. At 18 months, divergent growth aligned with opposing lipid metabolic states: a pro-anabolic profile (, ) supported fast growth, whereas a catabolic profile (, ) was associated with slow growth. These results demonstrate stage-specific transcriptional reprogramming in orbital fat underlying growth variation. This study provides a molecular framework for orbital fat-mediated growth regulation and highlights potential candidate genes for molecular breeding in bighead carp. - Source: PubMed
Publication date: 2026/03/04
Wang JunruLei QiLiu JunTian HaijunYao GaoyouSun ZhiruoGuo XushengTong Jingou - This cross-sectional study investigated the relationship between depressive symptoms and creative personality through the lens of epigenetic modifications within Hypothalamic-Pituitary-Adrenal (HPA) axis genes. By analyzing DNA methylation patterns in key HPA axis genes-including corticotropin-releasing hormone (CRH), its receptor (CRHR1), CRH binding protein (CRHBP), melanocortin 2 receptor (MC2R), steroidogenic acute regulatory protein (STAR), FK506 binding protein 5 (FKBP5), and the glucocorticoid receptor (NR3C1), we examined how methylation variation was associated with the depressive symptoms-creativity link in 371 participants (190 women, 181 men). Our findings revealed that among individuals with methylation patterns putatively associated with reduced HPA axis activity, higher depressive symptoms were positively associated with creative personality, suggesting that in this biological context, introspective aspects of depressive symptoms may coincide with creative propensities. Conversely, among individuals with methylation patterns putatively associated with heightened HPA axis activity, higher depressive symptoms were negatively associated with creative personality. These results suggest that the association between depressive symptoms and creativity is not uniform but differs based on methylation variation in genes involved in stress response regulation. The findings highlight the potential role of HPA axis-related biological factors in understanding individual differences in the depression-creativity relationship, though the cross-sectional design precludes causal inference. - Source: PubMed
Publication date: 2026/02/09
Feinmesser DanielShohat StavGerda RoiNin Nun AdiShoshani AnatSamra Nadra NasserVerbeke WillemVrticka PascalEin-Dor Tsachi - Cisplatin, a widely used antitumor agent, is limited in clinical application due to its ototoxicity. This study investigates the protective effects of obacunone, an active compound from Phellodendron bark, against cisplatin-induced hearing loss. Obacunone significantly improved the survival of cisplatin-treated House Ear Institute-Organ of Corti 1 (HEI-OC1) cells, preserved the cochlear explant, and enhanced auditory function in mice upon cisplatin treatment. Mechanistically, obacunone inhibited cisplatin-induced apoptosis by activating autophagy. Transcriptome profiling revealed that the expression of corticotropin-releasing hormone-binding protein (CRHBP) was increased in the cisplatin and obacunone co-treated group compared to the cisplatin-only group. Overexpression of CRHBP significantly enhanced autophagy and inhibited apoptosis, mirroring the effects of obacunone. Our findings demonstrate that obacunone promotes autophagy by upregulating CRHBP, thereby reducing cisplatin-induced hair cell apoptosis. This study provides a novel therapeutic strategy using the natural product obacunone for preventing cisplatin-induced hearing loss and highlights the potential of CRHBP as a target for otoprotective interventions. - Source: PubMed
Publication date: 2026/01/27
Cen ShaoqinHou ZhenxingZhang YuanWang NanZhao ZiheLi AoWan GuoqiangZhang TianhongGao Xia - Diabetes mellitus (DM) induces systemic vascular dysfunction and leads to life-threatening complications, including diabetic cardiomyopathy (DCM) and diabetic kidney disease (DKD), whose shared mechanisms remain elusive. In this study, we performed an in- -depth bioinformatics analysis to identify shared therapeutic targets and key molecular players in DKD and DCM. - Source: PubMed
Publication date: 2026/01/15
Liu JiarongChen WenZou YunXu Jixiong