Proteins IL-7 , Human
- Known as:
- Proteins Interleukin-7 , Human
- Catalog number:
- C086
- Product Quantity:
- 10μg
- Category:
- -
- Supplier:
- Novoprotein
- Gene target:
- Proteins IL-7 Human
Related genes to: Proteins IL-7 , Human
- Gene:
- IL7 NIH gene
- Name:
- interleukin 7
- Previous symbol:
- -
- Synonyms:
- IL-7
- Chromosome:
- 8q21.13
- Locus Type:
- gene with protein product
- Date approved:
- 1989-10-12
- Date modifiied:
- 2016-10-11
- Gene:
- IL7R NIH gene
- Name:
- interleukin 7 receptor
- Previous symbol:
- -
- Synonyms:
- CD127, IL7RA
- Chromosome:
- 5p13.2
- Locus Type:
- gene with protein product
- Date approved:
- 1991-08-07
- Date modifiied:
- 2019-04-23
Related products to: Proteins IL-7 , Human
Related articles to: Proteins IL-7 , Human
- Functional T-cell assays such as the IFN-γ ELISpot are increasingly used for immune phenotyping in infection, cancer, and critical illness. Many studies, including recent work linking low IFN-γ ELISpot responses to adverse outcomes in sepsis, compare patient samples to a single cross-sectional healthy donor baseline, implicitly assuming temporal stability of IFN-γ secretion in health. We conducted a longitudinal study of 9 healthy adults using whole-blood anti-CD3/anti-CD28 ELISpot assays with and without IL-7 co-stimulation. Absolute IFN-γ production varied significantly within individuals over approximately 10 weeks, whereas the ratio of IL-7-augmented to anti-CD3/anti-CD28-only responses remained remarkably stable across all readouts. This IL-7 responsiveness ratio may represent a robust, time-independent functional metric of intact T-cell signaling. These findings demonstrate that absolute IFN-γ ELISpot values in healthy individuals are dynamic and support ratio-based metrics for immune phenotyping applications. - Source: PubMed
Nguyen AnnemarieBrown Ruth-AnnBonavia Anthony S - - Source: PubMed
Publication date: 2026/04/17
Cranwell Victoria NRubino VivianaAdusumilli Prasad S - Grass carp reovirus (GCRV) is a major pathogen causing hemorrhagic disease in grass carp (Ctenopharyngodon idella), posing a serious threat to aquaculture. However, the protective efficacy of current inactivated vaccines remains limited, underscoring the need for effective adjuvants. In this study, a modified grass carp interleukin-7 (mIL-7) was generated by mutating glutamine at position 130 to glutamic acid (Q130E), based on integrated structural and energetic analyses. Structural modeling suggested that Q130E mutation may improve local conformational stability and alter the predicted interface involved in receptor interaction. Functional characterization demonstrated enhanced immunomodulatory activity of mIL-7. mIL-7 promoted peripheral blood lymphocyte chemotaxis and enhanced phagocytic activity of head kidney macrophages. Further, combined mIL-7 with inactivated GCRV vaccine significantly elevated expression of immune-related genes in macrophages, including IgM, MHC II, IFN1, and IL-10, together with reduced expression of the viral gene VP56 following GCRV challenge, indicating enhanced antiviral responsiveness. Through in vivo experiments, immunization with the mIL-7-adjuvanted vaccine resulted in significantly increased serum innate immune enzyme activities (CAT, ACP, Gpx) and upregulated expression of antiviral and inflammatory genes (IFN1, Mx2, and TNF-α) and enhanced IgM levels. These responses were associated with decreased viral loads, alleviated histopathological damage after GCRV-II challenge, and improved survival compared with vaccination alone. Collectively, these findings suggest that targeted modification of IL-7 may enhance its immunomodulatory function and adjuvant efficacy, providing a rational strategy for cytokine engineering and highlighting the potential of modified IL-7 to improve vaccine performance in grass carp. - Source: PubMed
Publication date: 2026/04/15
Wang ShijieLu YizhongChen GuanyuXu YuezongWang PengxuSu JianguoYang Chunrong - S100A12 as an indispensable molecular components inflammatory cytokines in human physiology. Notably, similar pathological mechanisms involving chronic low-grade inflammation are also observed in intervertebral disc degeneration (IVDD) and osteoporosis (OP), making the interplay between these diseases and inflammatory cytokines indisputable. Nevertheless, the precise identity of cytokines that concurrently fuel IVDD and OP remains elusive, hindering targeted therapeutic strategies. - Source: PubMed
Publication date: 2026/04/09
Wang ZexinChen BinLiu ZhenchuanZhang YuanqiangHan Leixiang - CD4 T cells orchestrate antiviral immunity but can also drive immunopathology in hepatitis B virus (HBV) infection. Peripheral helper T (Tph) cells are implicated in extra-lymphoid inflammation, yet their functional roles during HBV infection remain elusive. - Source: PubMed
Publication date: 2026/04/15
Li Xiao-YuZhang PengZhu MengmengLv QiaolanLi JingZhang XiangyanCheng YongqianMeng FanpingZhang MinZhou Ming-JuWang You-YuanYu YingyingFeng JinChen Si-YuanWang Ming-LiJiao Yan-MeiFan XingSong Jin-WenXu RuonanZhen ChengShi MingWang Fu-ShengZhang Chao