Proteins IL-4 , Human
- Known as:
- Proteins Interleukin-4 , Human
- Catalog number:
- C050
- Product Quantity:
- 10μg
- Category:
- -
- Supplier:
- Novoprotein
- Gene target:
- Proteins IL-4 Human
Related genes to: Proteins IL-4 , Human
- Gene:
- IL4 NIH gene
- Name:
- interleukin 4
- Previous symbol:
- -
- Synonyms:
- BSF1, IL-4, BCGF1, BCGF-1, MGC79402
- Chromosome:
- 5q31.1
- Locus Type:
- gene with protein product
- Date approved:
- 1988-08-10
- Date modifiied:
- 2016-10-05
- Gene:
- TLR2 NIH gene
- Name:
- toll like receptor 2
- Previous symbol:
- -
- Synonyms:
- TIL4, CD282
- Chromosome:
- 4q31.3
- Locus Type:
- gene with protein product
- Date approved:
- 1998-06-25
- Date modifiied:
- 2016-10-25
Related products to: Proteins IL-4 , Human
Related articles to: Proteins IL-4 , Human
- Cancer-associated cachexia (CAC) is a debilitating metabolic syndrome characterized by progressive adipose tissue and skeletal muscle wasting. Emerging evidence implicates the central nervous system (CNS) as a key regulator of systemic catabolism and CAC progression. We identify interleukin-4 (IL-4) as a potential mediator of CAC by investigating its actions on hypothalamic neuroendocrine circuits. - Source: PubMed
Publication date: 2026/09/27
Kim SaehaJang SooyeonPark SongyiMoon SubinPark YejinSong Dan-GyeongShin Dae-ChulKang JieunLee Seung EunKim DongbumSohn Jong-HeeLee KeunwookKim Ki WooKim Min-SeonLee Chan Hee - In response to the Letter by Song and Luan, we clarify the route and rationale of interleukin-4 (IL-4) administration in our published study. Recombinant mouse IL-4 was administered intracerebroventricularly as a mechanistic intervention to engage central IL-4/STAT6 signaling, whereas the reference to systemic administration in Section 4.4 was intended to describe systemic CGRP receptor blockade. We further clarify the intracerebroventricular procedure, including guide cannula implantation, anesthesia, recovery, and subsequent IL-4 administration. We also acknowledge that the non-IL-4 groups did not undergo matched guide-cannula implantation or intracerebroventricular vehicle administration, which represents a limitation when interpreting the in vivo effects specifically associated with IL-4. These clarifications define the appropriate scope of interpretation of the in vivo IL-4 findings. - Source: PubMed
Publication date: 2026/09/20
Li ZichaoGe Zhaoming - Osteoarthritis (OA) is a leading cause of global disability, with no available therapies that effectively halt disease progression. Impairment of macrophage efferocytosis, the clearance of apoptotic cells, is implicated in OA pathogenesis, yet the underlying mechanisms remain poorly understood. This study investigates the role of the anti‑inflammatory cytokine interleukin‑4 (IL‑4) in regulating macrophage efferocytosis during OA. - Source: PubMed
Publication date: 2026/09/19
Zhang HaipingYu ZiliangGao DagongXia FeiLi YixuanHe JiafengLiu WeiZhou Xiaozhong - Airway remodeling represents a key pathological feature of severe asthma. Although the interleukin-13 (IL-13) R130Q variant is associated with increased disease severity, its specific contribution to airway remodeling remains unclear. - Source: PubMed
Publication date: 2026/08/25
He YafangSun JingyiLi LuanluanBai ShashaZhai XiaojiaTian YePan QinBao YixiaoDing Guodong - Air pollution-associated allergic airway inflammation is an increasing public health concern. Interleukin‑4 (IL‑4) and interleukin‑13 (IL‑13), which activate the Signal Transducer and Activator of Transcription 6 (STAT6) pathway, a central mediator of allergic airway inflammation, may modulate the respiratory toxicities of pollutants. The present study describes the generation and validation of a stable STAT6 luciferase reporter assay in human airway epithelial cells for evaluating environmental toxicants that modulate STAT6 signaling. Human bronchial epithelial 16HBE14o cells were transduced with a STAT6-responsive luciferase reporter using a lentiviral vector, followed by optimization of puromycin selection and multiplicity of infection, and monoclonal isolation by limiting dilution. A stable clone with strong and reproducible induction across serial passages was selected. Reporter responsiveness was validated by IL-4/IL-13 stimulation, and STAT6 dependence was confirmed using selective STAT6, STAT5, and STAT3 inhibitors. Assay performance was quantified by Z'-factor analysis, which indicated reproducible signal separation. Furthermore, the assay was applied to individual air-pollution constituents, and benzo[b]fluoranthene and particulate matter significantly increased STAT6 reporter activity. This method provides a scalable approach for measuring STAT6 activity in airway epithelial cells and for prioritizing environmental toxicants that modulate allergic airway signaling. - Source: PubMed
Publication date: 2026/08/25
Moonwiriyakit AekkachaPothipan PhattarinToyingsirikul DhanpisitSantiwong PawitLusawat Sirapop