Proteins CCL28 , Human
- Known as:
- Proteins CCL28 , Human
- Catalog number:
- C095
- Product Quantity:
- 10μg
- Category:
- -
- Supplier:
- Novoprotein
- Gene target:
- Proteins CCL28 Human
Related genes to: Proteins CCL28 , Human
- Gene:
- CCL28 NIH gene
- Name:
- C-C motif chemokine ligand 28
- Previous symbol:
- -
- Synonyms:
- SCYA28, MEC, CCK1
- Chromosome:
- 5p12
- Locus Type:
- gene with protein product
- Date approved:
- 2002-08-22
- Date modifiied:
- 2016-03-01
Related products to: Proteins CCL28 , Human
Related articles to: Proteins CCL28 , Human
- Experimental hypoglycaemia induces a persistent inflammatory response. We investigated whether real-life sensor-detected hypoglycaemia (SDH) is associated with immune parameters in people with Type 1 and Type 2 diabetes and explored potential differences between the groups. - Source: PubMed
Publication date: 2026/09/17
Ajie MandalaAli NamamHendriksz Marijn SDivilly PatrickRietveld Marloes JAbbink Evertine JChoudhary PratikBrøsen Julie Maria BøggildPedersen-Bjergaard UlrikMcCrimmon Rory JEvans MarkMader Julia Kde Galan Bastiaan EStienstra RinkeTack Cees J - Stem cell-derived organoids are promising platforms for therapeutic screening in inflammatory bowel disease (IBD), but identifying functional organoid readouts with translational utility is challenging. Colon epithelial organoids from patients with ulcerative colitis (UC) overexpress chemokines CXCL1, CXCL11, CCL2, and CCL28, yet whether these epithelial inflammatory signatures correlate with disease activity and treatment response is unclear. This brief report explores whether organoid-retained chemokines correlate with disease activity and therapeutic outcomes. - Source: PubMed
Publication date: 2026/07/28
Alake Sanmi EKadam Anil HJester TraciMaynard Craig LOjo Babajide A - CCL28 functions as a key chemoattractant for IgA antibody-secreting cells (IgA ASCs) and is crucial for maintaining mucosal immune defense. Recent research has revealed IgA ASCs with immunosuppressive activity in non-mucosal tissues under inflammatory conditions. Here, we explored the contribution of CCL28 to chronic liver damage caused by carbon tetrachloride (CCl). - Source: PubMed
Publication date: 2026/08/05
Hara YutaBando MasamitsuHosokawa ShunyaOgo YukiOkumura RyoheiMatsuo KazuhikoNakayama Takashi - CCL25, a mucosal chemokine mainly produced in the gut, is known for its role in intestinal immunity through CCR9. In this study, we tested whether CCL25 also contributes to ocular immunity within the gut-eye axis during herpes simplex virus type 1 (HSV-1) infection. Using CCL25-deficient (CCL25 deficient) mice and wild-type C57BL/6J controls, which were infected ocularly with HSV-1 (McKrae strain), we found that CCL25 deficiency led to more severe corneal disease, increased viral replication, and reduced survival. CCL25 deficient mice also had fewer antiviral effector memory CD44CD4 and CD44CD8 T cells in the cornea, gastrointestinal tract, and draining lymph nodes, as well as reduced numbers of activated tissue-resident CD69CD103CD4 and CD69CD103CD8 T cells that produced interferon-γ. Immunohistochemistry showed strong CCL25 expression in the gut of wild-type mice but not in the cornea or conjunctiva. In addition, the mucosal chemokines CXCL14, CXCL17, and CCL28 were upregulated in infected ocular tissues of wild-type mice but remained low in CCL25 deficient mice, suggesting that CCL25 influences the expression of major mucosal chemokines. Collectively, these findings indicate that CCL25 supports recruitment of antiviral corneal tissue-resident effector memory T cells during ocular HSV-1 infection and supports the concept of a gut-eye axis in herpes immunity. The CCL25/CCR9 pathway may represent a promising therapeutic target to protect from herpetic eye disease. - Source: PubMed
Publication date: 2026/07/17
Rahman AzizurPrakash SwayamKaran SwetaNg Sarah Xue LePark GinaMaurya ChhayaGarcia AmericaIntharachalit KhanHwang JunseongTang Celine Tze YaoChow Reilly AndrewSuoth Baverly SabathiniLiao Emma JaneBenMohamed Lbachir - Mucosal chemokines (eg, CCL25, CCL28, CXCL14, and CXCL17) play key roles in protecting mucosal surfaces against invading infectious pathogens. However, their specific contributions to protection against genital herpes remain to be fully elucidated. Here, we investigated the role of CXCL14 as a mediator of mucosal immunity against genital HSV-2 infection and disease. - Source: PubMed
Publication date: 2026/06/03
Lekbach YassirPrakash SwayamVahed HawaQuadiri AfshanaRahman AzizurEl Fatimi El HoucineDorotta Joshua ChristianSuoth Baverly SabathiniMaurya ChhayaGarcia AmericaPark GinaBenMohamed Lbachir