Vrisko Star Mid-Range DNA Ladders, Plain
- Known as:
- Vrisko Star Mid-Range Desoxyribonucleic acid Ladders, Plain
- Catalog number:
- VP0036P
- Product Quantity:
- 500ul
- Category:
- -
- Supplier:
- Vrisko
- Gene target:
- Vrisko Star Mid-Range DNA Ladders Plain
Related genes to: Vrisko Star Mid-Range DNA Ladders, Plain
- Gene:
- STAR NIH gene
- Name:
- steroidogenic acute regulatory protein
- Previous symbol:
- -
- Synonyms:
- StAR, STARD1
- Chromosome:
- 8p11.23
- Locus Type:
- gene with protein product
- Date approved:
- 1996-04-24
- Date modifiied:
- 2016-10-05
Related products to: Vrisko Star Mid-Range DNA Ladders, Plain
Related articles to: Vrisko Star Mid-Range DNA Ladders, Plain
- Retinol (Ret), a hydrophobic vitamin A derivative, is widely used for skin rejuvenation, inhibiting the degradation of major extracellular matrix components such as collagen. Ret has been incorporated into lipid nanoparticles, such as liposomes, to improve stability. However, the long-term stability of these formulations under temperature variations as well as systematic optimization remain unknown. To overcome these limitations, we developed a retinol-loaded nanostructured lipid carrier (Ret-NLC) by optimizing the solid-to-liquid ratio (SL ratio) to enhance long-term stability, cellular delivery efficacy, and skin permeation. The formulation was optimized at an SL ratio of 6:4, achieving a particle size of approximately 200 nm and acceptable size distribution (polydispersity index, PDI ≈ 0.3). Ret-NLC stored at 25 and 4 °C maintained favorable dispersion characteristics during 12 weeks of storage, and release studies showed sustained release of Ret. In addition, among the tested SL ratios, Ret-NLC (6:4) exhibited the highest skin-mimetic membrane permeation, with an approximately 4.5-fold increase compared with free Ret, indicating suitability for the delivery of hydrophobic bioactive compounds to the skin. Biological evaluation revealed that Ret-NLC effectively reduced reactive oxygen species (ROS) and suppressed matrix metalloproteinase-1 (MMP-1) expression by 63.6%, which are key factors associated with skin aging and extracellular matrix degradation. Finally, Ret-NLC was incorporated into a cream formulation for practical applications. Compared with the Ret cream, the Ret-NLC cream exhibited improved formulation stability, while maintaining its physicochemical properties. Overall, these findings support the potential of Ret-NLC as a nanoplatform for delivering hydrophobic bioactive compounds in biopharmaceutical applications. - Source: PubMed
Publication date: 2026/09/24
Shin Hae KyungLee Eun YongLee SeunghyeonMin ChaelinYi MinyoungCho Sung YeonBok Sang HyeonRoh Young Hoon - This study developed ethylene-scavenging films by incorporating potassium permanganate (KMnO)-impregnated diatomite into a low-density polyethylene (LDPE) matrix. Various additives, including raw, alkaline-activated, and KMnO-impregnated diatomite (DA-KMnO and Alk-DA-KMnO), were incorporated into the films and tested. The additives did not improve mechanical or gas-barrier properties; however, they significantly enhanced thermal stability, crystallinity, and ethylene-removal capacity. The highest ethylene-removal capacities were achieved by the 1% DA/LDPE and 1% Alk-DA-KMnO/LDPE films, which exhibited capacities of 296.58 ± 2.07 μL/g, and 373.22 ± 13.83 μL/g, respectively. Practical storage trials using bananas, a climacteric fruit, demonstrated the efficacy of films. Bananas stored in neat LDPE ripened within 6 days, whereas those in 1% DA/LDPE films stayed green and fresh for up to 10 days, while those in 1% Alk-DA-KMnO/LDPE turned green-yellow after 9 days. Ultimately, these KMnO-based diatomite-LDPE films offer a viable solution for delaying ripening, maintaining firmness, and extending the shelf life of fresh produce. - Source: PubMed
Publication date: 2026/09/26
Yann ThearaWinotapun CharineeYos PhannyVoon Lee HweiWong Yew HoongNgamchuachit PanitaBoondamnoen Orathai - DNA methylation and its oxidative derivatives are key components of epigenetic regulation, yet their roles in plant repetitive DNA remain poorly understood. Here, we investigate the genomic distribution of oxidized cytosine modifications: 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxycytosine (5caC) within the repeat-rich genome of , a dioecious plant with heteromorphic sex chromosomes. - Source: PubMed
Publication date: 2026/09/22
Hubinský MarcelBačovský VáclavNovotná PavlaCegan RadimHobza RomanRodríguez Lorenzo José Luis - Variants in STAR, encoding Steroidogenic Acute Regulatory (StAR) protein, and CYP11A1, encoding the cholesterol Side-Chain Cleavage (SCC) enzyme, result in proximal steroidogenic defects. These are classically described as presenting with neonatal-onset primary adrenal insufficiency, with the additional finding of sex reversal in 46,XY newborns. However, the phenotypic spectrum is much wider. The present study aimed at describing the phenotypic heterogeneity and genotypes of patients with STAR and CYP11A1 variants followed up at a tertiary care centre in India. - Source: PubMed
Publication date: 2026/10/07
Priyadarshini SukanyaGupta PriyankaVerma AvadheshSharma RajniJain Vandana - The luminal androgen receptor (LAR) subtype of triple-negative breast cancer (TNBC) represents a formidable therapeutic challenge, necessitating sophisticated strategies that exploit unique tumor vulnerabilities. In the present work, we introduce a biomimetic nanotherapeutic that integrates single-atom iron nanocatalysts (FeSA) co-loaded with a CRISPR-Cas9 plasmid targeting Glutathione Peroxidase 4 (Gpx4), the key regulator of ferroptosis, and is camouflaged with a homologous cancer cell membrane to ensure precise tumor tropism and excellent biocompatibility. In an orthotopic LAR-TNBC model, the nanotherapeutic achieved ∼98% tumor regression and markedly extended survival. Comprehensive mechanistic analyses confirmed efficient on-target Gpx4 disruption, which synergistically amplified the FeSA-catalyzed ferroptotic cascade. Unbiased transcriptomic profiling further revealed extensive reprogramming of the tumor molecular landscape, resulting in significant cancer cell ferroptosis by DNA damage response and p53 signaling pathway activation. This work establishes a highly synergistic and targeted approach, presenting a potent therapeutic modality for aggressive and chemoresistant malignancies. - Source: PubMed
Publication date: 2026/10/06
Wang YuemeiLiang LeileiHuo DongliangGe DejieYu JiadieQiu ShuwenDuan Qiu-YiYin PeihaoShi JianlinHuo Minfeng