Mouse,Mus musculus,p101-PI3K,Phosphatidylinositol-4,5-bisphosphate 3-kinase regulatory subunit,Phosphoinositide 3-kinase regulatory subunit 5,PI3-kinase p101 subunit,PI3-kinase regulatory subunit 5,Pi
- Known as:
- Mouse,Mus musculus,p101-PI3K,Phosphatidylinositol-4,5-bisphosphate 3-phosphorylation catalyst regulatory active sequence peptide,Phosphoinositide 3-phosphorylation catalyst regulatory active sequence peptide 5,PI3-phosphorylation catalyst p101 active sequence peptide,PI3-phosphorylation catalyst regulatory active sequence peptide 5,Pi
- Catalog number:
- EIAAB30991
- Category:
- -
- Supplier:
- EIAab
- Gene target:
- Mouse Mus musculus p101-PI3K Phosphatidylinositol-4 5-bisphosphate 3-kinase regulatory subunit Phosphoinositide 5 PI3-kinase p101
Related genes to: Mouse,Mus musculus,p101-PI3K,Phosphatidylinositol-4,5-bisphosphate 3-kinase regulatory subunit,Phosphoinositide 3-kinase regulatory subunit 5,PI3-kinase p101 subunit,PI3-kinase regulatory subunit 5,Pi
- Gene:
- PIK3R5 NIH gene
- Name:
- phosphoinositide-3-kinase regulatory subunit 5
- Previous symbol:
- -
- Synonyms:
- P101-PI3K, p101
- Chromosome:
- 17p13.1
- Locus Type:
- gene with protein product
- Date approved:
- 2004-10-13
- Date modifiied:
- 2015-11-17
Related products to: Mouse,Mus musculus,p101-PI3K,Phosphatidylinositol-4,5-bisphosphate 3-kinase regulatory subunit,Phosphoinositide 3-kinase regulatory subunit 5,PI3-kinase p101 subunit,PI3-kinase regulatory subunit 5,Pi
Related articles to: Mouse,Mus musculus,p101-PI3K,Phosphatidylinositol-4,5-bisphosphate 3-kinase regulatory subunit,Phosphoinositide 3-kinase regulatory subunit 5,PI3-kinase p101 subunit,PI3-kinase regulatory subunit 5,Pi
- To investigate novel combination strategies for TP53-mutated acute myeloid leukemia (AML), focusing on the potential synergy between PI3Kγ inhibition and Azacitidine, and to elucidate the underlying molecular mechanisms. - Source: PubMed
Publication date: 2026/07/16
Huang GuiqinCai XiaoyaZhou YemingLiu YingMeng FankaiLi Dengju - This paper introduces an approach for inferring the gene regulatory networks in vortioxetine-induced glioblastoma cells to investigate vortioxetine's systemic effects. The approach uses an ordinary differential equation (ODE)-based inverse problem to evaluate the drug-induced gene interactions within the GLIOMA and ERBB pathways, which are deeply intertwined in cancers, by using time-series datasets. Time-series datasets were generated in triplicate at 0, 3, 6, 9, 12, and 24 h. The results of the ERBB pathway confirmed that was commonly activated, while , as a proto-oncogene in glioblastoma, was inhibited by genes across all three datasets. In particular, was commonly activated by in all three datasets. The results of the GLIOMA pathway confirmed that was commonly activated, while and , which are mostly overexpressed in human cancers, were inhibited across all three datasets. Additionally, an analysis of the independent datasets generated at 6 and 22 h after the vortioxetine injection identified the most distinct variable genes between the two time points: (1.96) and (-3.02) for the ERBB signaling pathway, and (1.30) and (-1.92) for the GLIOMA pathway. We conclude that vortioxetine, an antidepressant, decreases , a proto-oncogene involved in the ERBB signaling pathway, and , another proto-oncogene involved in the GLIOMA pathway, over time in glioblastoma cells. - Source: PubMed
Publication date: 2026/07/06
Kim Shinuk - Xanthine oxidase (XO) represents a key therapeutic target for the treatment of hyperuricemia. Although dietary anthocyanins are known to ameliorate hyperuricemia, their structure-activity relationship (SAR) concerning XO inhibition has not been fully elucidated. This study systematically evaluated the inhibitory effects of anthocyanin extracts derived from various dietary sources-including fruits, vegetables, cereals, and edible flowers-on XO activity, uric acid (UA) levels, and hyperuricemia-associated biomarkers. Using inhibition kinetics, spectroscopic techniques, and molecular simulations, we confirmed the direct binding of anthocyanins to XO and identified delphinidin-3--sambubioside (D3S) as the most potent inhibitor. experiments showed that anthocyanin extract from kale significantly suppressed XO activity and improved renal function in hyperuricemic mice. Transcriptomic and qPCR analyses further revealed that anthocyanins modulate the PI3K-Akt signaling pathway, specifically through downregulation of PIK3R5. These findings highlight the potential of specific anthocyanin structures, particularly D3S, as effective natural XO inhibitors for the management of hyperuricemia. - Source: PubMed
Publication date: 2026/07/07
Li Si-YiZhao MinLi YueWang NuoLi Xiu-JunZhao Ming-YueSun Fa-LinHu Bo-WenXue Hao-YuZhou YingYang Bao-RuLoyola Rodrigo QuintanaShu ChiLi BinTian Jin-Long - The rumen epithelium of Tibetan sheep plays a critical role in energy metabolism and immune defense; however, its post-transcriptional regulatory mechanisms under high-altitude hypoxia stress remain unclear. In this study, we employed integrated mRNA and miRNA transcriptome sequencing to analyze the adaptive strategies of the rumen epithelium in Tibetan sheep at different altitudes. A total of 2183 differentially expressed genes (DEGs) and 135 differentially expressed miRNAs (DEmiRNAs) were identified. Functional enrichment analysis revealed that DEGs and their target genes were significantly enriched in immune-related pathways such as the NF-κB signaling pathway and cytokine-cytokine receptor interaction, as well as metabolic pathways including oxidative phosphorylation and branched-chain amino acid degradation. Integrated network analysis highlighted key regulatory pairs, including targeting and , and regulating , suggesting coordinated modulation between mitochondrial homeostasis and immune responses. Specifically, the upregulation of immune genes (, ) and heat shock proteins at TS4500m indicates enhanced mucosal immunity and stress tolerance, while altered expression of metabolic genes reflects a shift in energy substrate utilization. These findings elucidate a complex mRNA-miRNA regulatory network that enables Tibetan sheep to maintain rumen epithelial integrity and energy balance under extreme high-altitude conditions, providing novel insights into the molecular basis of hypoxia adaptation in ruminants. - Source: PubMed
Publication date: 2026/05/28
Wang LeiHuang WeiSha YuzhuHe YanyuShao PengyangChen QianlingHe YapengFan JiangfengLiu XiuDu Wenhui - Inflammatory response-related signaling pathways are associated with Atherosclerosis (AS), yet the particular inflammation-related genes underpinning this process are still not fully characterized. - Source: PubMed
Publication date: 2026/05/20
Xu XuJiang MeilingHuang ZeyunZhu Guofu