GADD45G Monoclonal Antibody [1D3]
- Known as:
- GADD45G Monoclonal Antibody [1D3]
- Catalog number:
- A-6153-100
- Product Quantity:
- 100
- Category:
- -
- Supplier:
- EpigenTek
- Gene target:
- GADD45G Monoclonal Antibody [1D3]
Related genes to: GADD45G Monoclonal Antibody [1D3]
- Gene:
- GADD45G NIH gene
- Name:
- growth arrest and DNA damage inducible gamma
- Previous symbol:
- -
- Synonyms:
- DDIT2, GADD45gamma, GRP17, CR6
- Chromosome:
- 9q22.2
- Locus Type:
- gene with protein product
- Date approved:
- 1999-09-06
- Date modifiied:
- 2016-10-05
- Gene:
- IGKV1D-37 NIH gene
- Name:
- immunoglobulin kappa variable 1D-37 (non-functional)
- Previous symbol:
- -
- Synonyms:
- IGKV1D37, O4
- Chromosome:
- 2p11.2
- Locus Type:
- immunoglobulin gene
- Date approved:
- 2000-04-18
- Date modifiied:
- 2012-02-10
- Gene:
- TBC1D3 NIH gene
- Name:
- TBC1 domain family member 3
- Previous symbol:
- -
- Synonyms:
- TBC1D3A, DKFZp434P2235, PRC17
- Chromosome:
- 17q12
- Locus Type:
- gene with protein product
- Date approved:
- 2003-05-29
- Date modifiied:
- 2015-11-18
- Gene:
- TBC1D3B NIH gene
- Name:
- TBC1 domain family member 3B
- Previous symbol:
- TBC1D3I
- Synonyms:
- PRC17
- Chromosome:
- 17q12
- Locus Type:
- gene with protein product
- Date approved:
- 2005-04-28
- Date modifiied:
- 2015-11-18
- Gene:
- TCTE3 NIH gene
- Name:
- t-complex-associated-testis-expressed 3
- Previous symbol:
- -
- Synonyms:
- TCTEX1D3
- Chromosome:
- 6q27
- Locus Type:
- gene with protein product
- Date approved:
- 1991-11-19
- Date modifiied:
- 2014-11-19
Related products to: GADD45G Monoclonal Antibody [1D3]
Related articles to: GADD45G Monoclonal Antibody [1D3]
- Alzheimer's disease (AD) is a prevalent neurodegenerative disorder worldwide lacking effective treatments. Protocatechuic acid (PCA), a natural polyphenol found in various foods and medicinal herbs, exhibits diverse bioactivities; but its role in AD remains unclear. This study investigated the neuroprotective effects and mechanisms of PCA. In vitro, PCA significantly attenuated glutamic-induced cytotoxicity, oxidative stress, calcium influx, and apoptosis in PC12, SH-SY5Y, and HT22 cells. In vivo, PCA improved cognitive performance in the Morris water maze, open field, and novel object recognition tests in a D-galactose/AlCl₃-induced AD mice, and mitigated hippocampal and cortical histopathological damage. Integrated transcriptomic and network pharmacology analyses identified the apoptosis, p53, and MAPK as key pathways. RT-qPCR and western blot analyses revealed that PCA downregulated p53, GADD45B, GADD45G, and phosphorylated p38. Collectively, these findings demonstrate that PCA alleviates AD progression by inhibiting the p53/GADD45/MAPK axis, positioning it as a promising natural candidate for AD prevention. - Source: PubMed
Publication date: 2026/09/27
Wang JiaxinTu XinminYang RuiwenKang JieGu AimingHan BingKai Guoyin - This study aimed to reveal the relationship between experimental varicocele and melatonin levels. Forty adult Wistar albino rats were used in this study. Control (C), Melatonin (M), Varicocele (V), Varicocele+Melatonin (V + M) were planned. Varicocele was created on the first day of the experiment by opening the abdominal area, narrowing the left renal vein with a 0.85 mm metal wire and using a 4-0 silk suture, after removing the metal wire, the animal was closed (with a 3-0 silk suture) and kept for 60 days. Melatonin was administered at 10 mg/kg ip (intraperitoneal) on the 61st day, every 24 h for 7 days. Histological analysis and GADD34, GADD45g, GADD153 immunohistochemical staining were performed. Additionally, StAR and GDNF gene expressions were examined. ABP, FSH, LH, Testosterone, Melatonin hormones, TAS and TOS levels were evaluated from blood serum taken from experimental animals. According to our results, group V showed a decrease in testicular weights, seminiferous tubule diameter, and JTBS score, while GADD34, GADD45g and GADD153 proteins increased. In group V, testosterone and TAS levels decreased and TOS levels increased. In group V, testosterone, FSH, ABP, melatonin levels decreased and LH level increased. StAR and GDNF gene expression also decreased in group V. In the V + M group where melatonin was applied, an improvement was observed in biochemical parameters as well as histological, immunohistochemical and gene expression analyses. During varicocele, endogenous melatonin level decreases and activates various mechanisms and hormones in the tissue, including GADDs, causing loss of structure and function, while melatonin acts as a good therapeutic on varicocele. - Source: PubMed
Önal EsraBaydilli NumanKarabulut Derya - Heat stress compromises dairy cow productivity and metabolic health through impaired nutrient partitioning and oxidative stress. Cobalamin is an essential cofactor for methylmalonyl-CoA mutase, the key enzyme regulating ruminal propionate production and hepatic gluconeogenic metabolism. However, the underlying molecular mechanisms, particularly the hepatic transcriptional responses to cobalamin under heat stress conditions, remain unclear. This study evaluated the effects of coated cobalamin (CCA) supplementation on lactation performance, nutrient digestibility, rumen fermentation, blood metabolites, and hepatic transcriptome in heat-stressed Holstein cows. - Source: PubMed
Publication date: 2026/09/03
Liu YongjiaGuo ZitaiCao NaDiao ZhichengMa LuYang YongxinZhang YuBu Dengpan - Senescence-related molecular nodes linking hepatic stress with immune dysregulation in metabolic dysfunction-associated steatotic liver disease (MASLD) remain poorly defined. This study aimed to identify and experimentally validate a senescence-related gene (SRG) signature associated with immune dysregulation in MASLD. Four transcriptomic datasets (127 controls, 127 MASLD) were integrated as the discovery cohort. Candidate SRGs were identified through differential expression analysis, weighted gene co-expression network analysis, and three machine learning algorithms. Immune infiltration was assessed using CIBERSORT, and a three-gene signature was evaluated in internal and external cohorts. Potential GADD45G-associated compounds were predicted by molecular docking. Experimental validation was performed in high-fat diet (HFD)-induced obese mice and palmitic acid (PA)-stimulated bone marrow-derived macrophages (BMDMs). Single-cell RNA sequencing analysis of GSE300744 was further performed to evaluate GADD45G distribution in hepatic cell populations. SOCS1, SOCS2, and GADD45G were identified as core SRGs. Their expression was reduced in MASLD liver tissues and correlated with histological features and immune alterations. The three-gene signature showed favorable classification performance in validation cohorts. In HFD mice, GADD45G expression was decreased at both mRNA and protein levels, with reduced immunoreactivity in F4/80-positive hepatic macrophages. Single-cell analysis further supported macrophage-associated expression of Gadd45g. In PA-stimulated BMDMs, reduced GADD45G protein expression was partially restored by camptothecin and myristicin treatment. Overall, SOCS1, SOCS2, and GADD45G represent a candidate senescence-related immune signature associated with MASLD. The macrophage-associated reduction in GADD45G and its modulation in vitro provide preliminary evidence for a potential role of GADD45G in MASLD-associated immune dysregulation. - Source: PubMed
Publication date: 2026/08/07
Tang WenjingWang WeixiaZhang ShuyangZhou XinHe LinfengZeng Tianshu - Reproductive inefficiency remains a major contributor to heifer culling and reduced herd longevity in beef systems. This study examined the molecular basis of fertility by analyzing granulosa cells and follicular fluid from Angus-Simmental crossbred heifers classified as fertile or subfertile. - Source: PubMed
Publication date: 2026/07/29
Banerjee PriyankaPhillips RachelHolliman Anna GRodning Soren PDiniz Wellison J SDyce Paul W