C1INH antibody
- Known as:
- C1INH (anti-)
- Catalog number:
- 10-1918
- Product Quantity:
- 200 ul
- Category:
- -
- Supplier:
- Fitzgerald
- Gene target:
- C1INH antibody
Related genes to: C1INH antibody
- Gene:
- SERPING1 NIH gene
- Name:
- serpin family G member 1
- Previous symbol:
- C1NH
- Synonyms:
- C1IN, C1-INH, HAE1, HAE2, C1INH
- Chromosome:
- 11q12.1
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2019-04-23
Related products to: C1INH antibody
Related articles to: C1INH antibody
- Hereditary angioedema (HAE) is a rare congenital disorder characterized by recurrent episodes of subcutaneous and submucosal swelling, which can progress to life-threatening laryngeal obstruction. The most common form of HAE results from mutations in the SERPING1 gene, which encodes C1-esterase inhibitor (C1-INH). HAE belongs to the broader category of serpinopathy, in which misfolded serine protease inhibitors polymerize and are retained within the endoplasmic reticulum, leading to both loss-of-function and toxic gain-of-function effects. - Source: PubMed
Publication date: 2026/04/29
Long Luong HoangItsukage ShizuMatsuoka YoshikazuShirouzu YasumasaTanizaki HideakiCraig Timothy JHitomi Hirofumi - Following subarachnoid hemorrhage (SAH), long-lasting inflammation triggered by activated glial cells has adverse effects on neurological recovery. As an α2 adrenoceptor agonist commonly utilized for sedative purposes, dexmedetomidine (DEX) has demonstrated the ability to confer neuroprotective effects across diverse physiological or pathological conditions. This study was designed to determine whether DEX protects against SAH by altering astrocytic reactivity. - Source: PubMed
Publication date: 2026/04/24
Yin JiaxiangXu QiaominLu KuanWu JinchaoCai Weiwei - Systemic lupus erythematosus (SLE) is a chronic, multi-organ autoimmune disease characterised by a highly heterogeneous presentation. Specific genetic variations predispose patients to the disease, and rare monogenic forms caused by single-gene variations have been identified in a small percentage of patients, often with early disease onset. In this study, we used exome sequencing in a large cohort of patient with juvenile-onset SLE to gain insight into the genetic basis of juvenile SLE (jSLE). - Source: PubMed
Publication date: 2026/04/01
Tusseau MaudKhaldi-Plassart SamiraLabalme AudreyMathieu Anne-LaureRiller QuentinMolitor CorentinSimonet ThomasViel SebastienGaboriaud ChristineThielens NicoleHeiser LionelChopin EmilieRouvet IsabelleFabien NicoleGoncalves DavidFremeaux-Bacchi VéroniqueEl-Sissy CarinePottier NicolasLarrue RomainRanchin BrunoLaurent AudreyFouillet-Desjonqueres MarineJouret MaurineMekinian ArsèneYamashita MotoiMorio TomohiroHachulla EricMelki IsabelleKone-Paut IsabelleBallot ClaireReumaux HeloisePillet PascalHarambat JeromeRichez ChristopheRicher OlivierHatchuel YvesLouillet FerielleLega Jean-ChristopheDurieu IsabelleWelfringer-Morin AnnePicard CapucineMessadi WassilaSarrot-Reynauld FrançoiseSanlaville DamienBader-Meunier BrigitteWalzer ThierryLesca GaëtanRieux-Laucat FrédéricBelot Alexandre - Despite the remarkable success of immune checkpoint inhibitor (ICI) therapy in solid tumors, immune-related adverse events (irAEs) have posed great challenges in the whole-course management of ICI immunotherapy. Reliable biomarkers helping to predict irAEs are still limited and lacking. - Source: PubMed
You LitingZhai JianzhaoXin ZhaodanNa FeifeiWen YangLi JinSong JiajiaBai LingZhou XiaohanYing BinwuZhou Juan - Hereditary angioedema (HAE) is a rare, potentially life-threatening genetic disorder characterized by recurrent, bradykinin-mediated swelling episodes, with substantial impact on morbidity, quality of life, and healthcare resource use. Targeted agents have reshaped long-term prophylaxis (LTP); however, effective implementation depends on clinical decision-making as well as health-system access and structural constraints. - Source: PubMed
Publication date: 2026/03/31
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