GP340 antibody
- Known as:
- GP340 (anti-)
- Catalog number:
- 10-1889
- Product Quantity:
- 200 ul
- Category:
- -
- Supplier:
- Fitzgerald
- Gene target:
- GP340 antibody
Related genes to: GP340 antibody
- Gene:
- DMBT1 NIH gene
- Name:
- deleted in malignant brain tumors 1
- Previous symbol:
- -
- Synonyms:
- GP340, muclin, SALSA, Gp-340, hensin, vomeroglandin
- Chromosome:
- 10q26.13
- Locus Type:
- gene with protein product
- Date approved:
- 1997-09-05
- Date modifiied:
- 2017-02-28
Related products to: GP340 antibody
Related articles to: GP340 antibody
- Bovine leukemia virus (BLV) is an oncogenic retrovirus that naturally infects cattle. Once infected, the virus persists indefinitely throughout life at a transcriptionally silent stage. Soon after infection, humoral and cytotoxic activities efficiently abolish the viral replicative cycle, allowing only mitotic expansion of provirus-carrying cells. These anti-viral activities persist throughout the animal's life indicating that the immune system is permanently stimulated by BLV antigens. Although protein production is abolished during the chronic stage, viral transcription is not completely shut down. Extracellular vesicles (EVs) are nano-sized lipid bilayer vesicles released from most cells and play multiple roles in cell-to-cell communication, including immune modulation, angiogenesis, and transformation of cells by transferring genetic material and functional proteins. Colostrum is rich in EVs that carry bioactive proteins and RNAs reflecting maternal physiology and immune status. In this study, we aimed to characterize how BLV infection influences the protein cargo of colostrum-derived EVs. - Source: PubMed
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Pérez Cecilia ValeriaCarignano Hugo AdriánMarchetti Yamila CelesteGonzález Diego DanielRuiz VanesaTrono Karina GabrielaMongini Claudia - Diabetic wounds represent one of the most severe complications of diabetes, and their clinical management remains challenging. This study investigated the therapeutic potential of adipose-derived stem cell-derived exosomes (ADSCs-Exo) for diabetic wounds. We isolated ADSCs and their exosomes, and by using Transwell and CCK-8 assays, we found that ADSCs-Exo were associated with proliferation and migration of keratinocytes and fibroblasts, and that they also enhanced the angiogenic activity of endothelial cells in vitro. In contrast, these promotive effects were significantly attenuated when exosomes derived from ADSCs with DMBT1 knockdown via siRNA (ADSCs-Exo) were applied. In a diabetic mouse model, ADSCs-Exo treatment significantly accelerated wound healing, whereas the pro-healing capacity of ADSCs-Exo was markedly reduced. To further explore the underlying mechanism, we performed RNA sequencing, which suggested that ADSCs-Exo might exert their therapeutic effects by alleviating ferroptosis and promoting cell proliferation. Subsequent experiments, including TEM, ROS assays, JC-1 staining, and tissue immunofluorescence, provided further support for these mechanistic findings. In summary, this study demonstrates that DMBT1 in ADSCs-Exo participates in alleviating ferroptosis in diabetic wound tissue, which may contribute to creating a favorable microenvironment for cell proliferation and promoting wound healing. This discovery provides a novel potential therapeutic target and strategy for the clinical treatment of diabetic wounds. - Source: PubMed
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Liu YanWang JinnanCai YujiaoZhu XiaokeYuan ZhanyuanDai JiahuiChe DehuiCao Dongsheng - This study aimed to evaluate the profile of salivary proteins in young hookah and conventional cigarette users without apparent oral mucosal lesions, and to correlate the findings with clinical variables related to tobacco use. - Source: PubMed
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Costa Thayná Isabele Stopiellode Souza Salardani Murilodo Carmo Carvalho Bruna FernandesZimiani Caroline FariaSantos Joyce NascimentoDe Rossi TatianeAlmeida Janete DiasHayashi Jackelinne YukaTashima Alexandre KeijiLeme Adriana Franco PaesZelanis AndréAlves Mônica Ghislaine Oliveira - In order to reveal the molecular response characteristics of different tissues of under ammonia nitrogen stress, the liver, gill, muscle, kidney and brain tissues of juvenile (12.05 ± 0.04 g) under 25 mg/L ammonium chloride stress were used as the research objects. The transcriptome sequencing technology was used to systematically analyze the transcriptional expression changes. A total of 204.42 Gb transcription data were obtained, and a total of 3039 DEGs were detected, of which 1331 genes were up-regulated and 1708 genes were down-regulated. Ten DEGs were randomly selected for quantitative qRT-PCR analysis, and the results confirmed that the transcriptome results were reliable. Multi-organ synergy analysis suggested that overlapping DEGs (e.g., , , , , and ) may exhibit similar or opposing regulatory patterns across organs, potentially reflecting complementary and coordinated mechanisms in immune regulation, inflammatory responses, energy allocation, and detoxification strategies among organ systems. GO and KEGG pathway enrichment analysis of differentially expressed genes showed that ammonia nitrogen mainly affected immune inflammation-related processes, material transport and degradation, protein homeostasis maintenance, oxidative stress defense, membrane lipid metabolism remodeling, and energy metabolism regulation. In different tissues, genes related to specific functions are enriched according to their physiological roles: in the liver, genes related to detoxification and damage clearance are enriched; in the gill, genes related to barrier defense and antioxidant/detoxification are enriched; in the kidney, genes related to damage response and metabolic regulation are enriched; in the brain, genes related to membrane lipid homeostasis and protective stress are enriched; and in the muscle, genes related to energy metabolism and structural function adjustment are enriched. This study elucidated the multi-tissue response characteristics of under ammonia nitrogen stress at the transcriptome level, providing fundamental data and references for further clarifying the mechanisms of ammonia nitrogen toxicity in fish and screening stress-responsive marker genes. - Source: PubMed
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