LAMP3 protein
- Known as:
- LAMP3 protein
- Catalog number:
- 80R-4396
- Product Quantity:
- 50 ug
- Category:
- -
- Supplier:
- Fitzgerald
- Gene target:
- LAMP3 protein
Related genes to: LAMP3 protein
- Gene:
- LAMP3 NIH gene
- Name:
- lysosomal associated membrane protein 3
- Previous symbol:
- -
- Synonyms:
- LAMP, TSC403, DC-LAMP, DCLAMP, CD208
- Chromosome:
- 3q27.1
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-29
- Date modifiied:
- 2016-10-05
Related products to: LAMP3 protein
Related articles to: LAMP3 protein
- To characterise the pharmacokinetics (PK) of ceftazidime-avibactam (CAZ-AVI) and explore the dynamics of a broad blood immune biomarker panel in critically ill patients with hospital-acquired (HAP) or ventilator-associated pneumonia (VAP) caused by Klebsiella pneumoniae. - Source: PubMed
Publication date: 2026/07/29
O'Jeanson AmauryNielsen Elisabet IAthanassa ZoeGinosyan AghavniIoannidis KonstantinosManioudaki SofiaPetsa IrinaGiamarellou HelenBader IosifSkarmoutsou NikolettaMylona EvgeniaSakagianni AikateriniLoryan IrenaKaraiskos IliasFriberg Lena E - Acute myeloid leukemia (AML) is a malignancy characterized by abnormal myeloid proliferation. Despite therapeutic advances, relapse is frequent. Understanding the tumor microenvironment (TME), particularly the dysfunction and interactions of natural killer (NK) cells, is essential for improving immunotherapeutic strategies such as chimeric antigen receptor T-cell (CAR-T) and chimeric antigen receptor natural killer cell (CAR-NK) therapies. - Source: PubMed
Publication date: 2026/07/28
Li JunyiZhu HuoyanYe ChaoqiongXu ShengnanWu ZhihuaDeng Yuping - Fistulizing Crohn's disease represents a severe and disabling complication characterized by transmural inflammation and aberrant tissue remodeling. Although fissures are considered precursors of fistulas, the cellular and molecular mechanisms driving this transition remain poorly defined. We aimed to characterize the spatial immune-stromal interactions underlying fissure formation and progression toward fistula. - Source: PubMed
Massimino LucaNicolò SabrinaParigi Tommaso LorenzoMino SaraBugatti MattiaNicola FrancescaLorè Nicola IvanVillanacci VincenzoParente PaolaBossa FabrizioPalmieri OrazioSileri PierpaoloDanese SilvioUngaro Federica - : Sex differences are well recognized in the epidemiology and clinical manifestations of knee osteoarthritis (OA), with women exhibiting a higher prevalence and greater disease severity than men. Although synovial inflammation is increasingly recognized as a key contributor to OA pathology, the molecular mechanisms underlying sex-related differences in OA synovium remain incompletely understood. : Synovial tissues were obtained from patients with knee OA undergoing total knee arthroplasty. RNA sequencing (RNA-seq) was initially performed using synovial samples from five female and five male patients to identify differentially expressed genes (DEGs) associated with sex. Candidate genes identified by RNA-seq were subsequently validated by quantitative PCR (qPCR) using an independent cohort consisting of 78 female and 27 male patients. Multivariable analyses adjusted for age, body mass index (BMI), and Kellgren-Lawrence (KL) grade were performed to evaluate the independent association between gene expression and sex. : RNA-seq analysis identified 12 female-upregulated genes and 13 male-upregulated genes. Several Y chromosome-related genes showed marked male-specific expression and were excluded from downstream validation analyses. qPCR validation demonstrated significantly higher expression of , , , , and in female synovial tissues. After adjustment for age, BMI, and KL grade, (β = 0.829, = 0.004), (β = 0.596, = 0.029), and (β = 0.698, = 0.014) remained significantly associated with female sex. In contrast, became significantly associated with male sex after multivariable adjustment (β = 0.753, = 0.009). : Distinct sex-related synovial gene expression profiles were identified in knee OA. In particular, , , and were independently associated with female sex, suggesting potential sex-related pathology in OA synovium. These findings provide new insight into the molecular basis of sex differences in OA and may contribute to the development of sex-specific therapeutic strategies. - Source: PubMed
Publication date: 2026/07/11
Norisugi AkiraUchida KentaroFukushima KensukeMukai ManabuOhashi YoshihisaUekusa YuiTsukada AyumiIwase DaiAikawa JunMetoki YukieInoue GenTakaso Masashi - Tertiary lymphoid structures (TLSs) are spatial immune niches in solid tumors, but their relationship to mature regulatory dendritic-cell (mregDC) states in ovarian cancer remains incompletely resolved. We integrated public gynecological-tumor single-cell RNA sequencing, representative CD11C/HLA-DRA/LAMP3/CCR7 multiplex immunofluorescence, public Xenium and multi-sample spatial transcriptomics, TCGA-OV immune deconvolution and exploratory prognostic modeling, scTenifoldKnk and CellOracle perturbation analyses, and supplementary computational drug prioritization. A LAMP3+CCR7+ dendritic-cell state showed mature migratory, antigen-presentation, checkpoint, and NF-κB/TNF-associated programs. Spatial analyses linked TLS-score-defined regions to mregDC, antigen-presentation/MHC-II proxy, and interferon-associated signals, with distance-gradient analyses supporting TLS-proximal enrichment. Immune deconvolution associated the TLS/mregDC axis with an immune-infiltrated TCGA-OV contexture, whereas adjusted analyses emphasized dependence on broader immune-program richness. Perturbation analyses nominated candidate regulatory axes for experimental testing, and the supplementary drug-prioritization layer was retained only as target-class hypothesis support. These data support a hypothesis-generating model of a TLS-associated LAMP3+CCR7+ mregDC antigen-presentation program in ovarian cancer, while requiring raw-channel tissue validation, functional perturbation, and independent clinical testing. - Source: PubMed
Publication date: 2026/07/14
Lu FeifanZhang TingLi ZhixuanYao RenqiHu HaoGuan RuiXu Mingjuan