GP340 antibody
- Known as:
- GP340 (anti-)
- Catalog number:
- 10-1890
- Product Quantity:
- 200 ul
- Category:
- -
- Supplier:
- Fitzgerald
- Gene target:
- GP340 antibody
Related genes to: GP340 antibody
- Gene:
- DMBT1 NIH gene
- Name:
- deleted in malignant brain tumors 1
- Previous symbol:
- -
- Synonyms:
- GP340, muclin, SALSA, Gp-340, hensin, vomeroglandin
- Chromosome:
- 10q26.13
- Locus Type:
- gene with protein product
- Date approved:
- 1997-09-05
- Date modifiied:
- 2017-02-28
Related products to: GP340 antibody
Related articles to: GP340 antibody
- To generate a single-cell atlas of colorectal cancer (CRC) development in Lynch syndrome (LS), and to delineate the associated cellular reprogramming and intercellular communication networks. - Source: PubMed
Chen ShangxiangFeng JishenFang ZhengkaiJiang YuhaoDuanmu JinzhongYu XinWang JunfuJiang Qunguang - Salivary agglutinin, also known as deleted in malignant brain tumors 1 (DMBT1), is an anti-microbial protein. DMBT1 is low in saliva from patients with oral squamous cell carcinoma (OSCC) and dramatically increases after treatment, with accompanying microbial changes. While this suggests an association between DMBT1 suppression and changes in the oral microbiota, causation has not been established. DMBT1 is also a tumor suppressor protein; its loss promotes OSCC progression, but its role in OSCC development is unknown. In this study, OSCC development was investigated in a murine carcinogen model that simulates human OSCC. Microbiota were standardized between Dmbt1 knockout (Dmbt1) and wild-type (Dmbt1) mice via interbreeding and co-housing. Saliva was collected at baseline and at 4, 8, 12, 16, and 22 weeks post-carcinogen initiation (stopped at 16 weeks). Tongues were harvested at week 22 for histopathology, and the salivary microbiome was profiled by 16S rRNA sequencing. Microbial diversity metrics and conditional dependence networks assessed community structure, while longitudinal patterns were analyzed using a locally sparse varying coefficient mixed model and functional principal component analysis (fPCA). - Source: PubMed
Publication date: 2026/04/10
de Medeiros Marcell CostaFontaine SimonDanella ErikaHillman EthanSchmidt Thomas MFurgal AllisonWellik Deneen MInohara NaohiroNúñez GabrielLi GenChen Grace YD'Silva Nisha J - Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of methotrexate-associated lymphoma arising in immune deficiency/dysregulation (MTX-associated IDD-DLBCL) among rheumatoid arthritis patients treated with MTX and is characterized by frequent spontaneous regression (SR) after MTX withdrawal. However, some patients do not achieve SR and have poor outcomes. Epstein-Barr virus (EBV) infection correlates with frequent SR but does not fully explain clinical heterogeneity. We investigated prognostic factors irrespective of EBV infection status. We analyzed 21 MTX-associated IDD-DLBCL cases applying the nCounter PanCancer Immune Profiling Panel and immunohistochemistry (IHC) to identify predictors of non-SR cases. Ten patients were classified as SR and 11 as non-SR. Gene expression profiling revealed higher expression of CD83, ICOSLG, IL21R, BCL6, CD40, PAX5, CXCR5, CD79A, DMBT1, and TNFRSF13C in non-SR cases. We therefore focused on CD83, which showed the highest fold change and the most significant P value among these markers. Although CD83 is reported to be a surface marker of mature dendritic cells, IHC analysis revealed that CD83 was more frequently expressed on tumor cells than on dendritic cells. High CD83 IHC positivity (≥15%) in tumor cells correlated with mRNA levels and predicted non-SR after MTX withdrawal. Multivariate analysis identified CD83 IHC high expression as an independent predictor of non-SR cases. High CD83 expression is an independent prognostic factor in MTX-associated IDD-DLBCL, and combined evaluation may refine risk stratification and guide clinical decisions. - Source: PubMed
Sawada KeisukeTakahashi TakumiFukumura YukiOnagi HirokoAshizawa KarinYamashita TakahisaYamamoto WataruTakayanagi NatsukoAdachi AkikoKashimura MakotoTabayashi TakayukiTamaru Jun-IchiHigashi MorihiroMomose Shuji - Acute pancreatitis (AP) ranges from mild to severe, and severe disease frequently causes multi-organ damage, with intestinal injury being a major complication. The mechanisms underlying SAP-induced intestinal injury remain unclear, particularly regarding spatial cellular reorganization and functional interactions. - Source: PubMed
Publication date: 2026/01/30
Zhang LechangXu ChangqinSu TongXiao TongYi XuFeng YueminWang JingZhao Shulei - Streptococcus mutans, a causative organism of dental caries, has also been implicated in the pathogenesis of cardiovascular disease (CVD). Substance P (SP) involvement in physiological and pathological processes within the cardiovascular system is currently the foci of research. The role of SP in modulating the human aortic endothelial cells (HAECs) response to S. mutans within the context of CVD pathogenesis has not been examined. This study aimed to investigate SP expression in S. mutans-stimulated HAECs and to clarify the role of SP in the interaction between S. mutans and HAECs, considering its cooperative action with an innate immune factor DMBT1. - Source: PubMed
Publication date: 2026/02/03
Oho TakahikoNagata EmiTamaki Naofumi