P4HB protein
- Known as:
- P4HB protein
- Catalog number:
- 80R-4394
- Product Quantity:
- 50 ug
- Category:
- -
- Supplier:
- Fitzgerald
- Gene target:
- P4HB protein
Related genes to: P4HB protein
- Gene:
- P4HB NIH gene
- Name:
- prolyl 4-hydroxylase subunit beta
- Previous symbol:
- PO4DB, ERBA2L
- Synonyms:
- PDIA1, PROHB, DSI, GIT, PDI, PO4HB, P4Hbeta
- Chromosome:
- 17q25.3
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2016-10-05
Related products to: P4HB protein
Related articles to: P4HB protein
- Polyhydroxyalkanoates (PHAs) are a structurally diverse family of microbially synthesised, biodegradable polyesters that accumulate as intracellular carbon and energy reserves under conditions of nutrient imbalance. Their combination of adjustable mechanical performance with controlled hydrolytic and enzymatic degradation, and non-toxic degradation intermediates (ex. D-3-hydroxybutyrate) has made them a longstanding candidate biomaterial for human tissue engineering, drug delivery, and resorbable implants. Comparatively, their application in veterinary medicine remains an emerging and fragmented field, despite an arguably stronger practical case: veterinary practice faces acute pressure to replace non-degradable sutures, orthopaedic hardware, and single-use plastics with materials that avoid secondary retrieval surgery, that can be produced at low cost for large-scale animal use, and that align with growing regulatory and consumer demand for sustainable animal healthcare. This review consolidates current understanding of PHA biosynthesis, covering the core: phaA-phaB-phaC pathway, medium-chain-length variants, microbial producers, feedstock flexibility, and metabolic engineering strategies for yield improvement. It also examines material modification strategies, including blending, chemical grafting, surface functionalisation, electrospinning, and additive manufacturing, used to adapt PHAs for specific veterinary form factors. The clinical and preclinical evidence base is presented in detail across wound management, orthopaedic and soft-tissue regeneration, cardiovascular tissue engineering, drug delivery, and surgical devices, with attention to species-specific considerations in companion animals, horses, and food-producing ruminants. This review relies exclusively on peer-reviewed literature for its quantitative claims, while transparently noting where veterinary-specific data are lacking, extrapolated from rodent or human models, or in need of independent verification. Persistent barriers like production cost, batch-to-batch variability, absence of veterinary-specific regulatory pathways, and limited long-term in vivo safety data in large animals are analysed critically, alongside translational opportunities including waste-feedstock valorisation, hybrid PHA/ceramic and PHA/natural-polymer composites, and stimuli-responsive formulations. We conclude that PHAs are scientifically well positioned but institutionally under-validated for veterinary translation, and we outline a concrete research agenda to close this gap. - Source: PubMed
Publication date: 2026/09/16
Anita Adriana ElenaAnita Dragos ConstantinNegut IrinaRistoscu Carmen - Poly-4-hydroxybutyrate (P4HB) biosynthetic mesh offers a bioabsorbable alternative to permanent synthetic mesh in ventral hernia repair, but comparative outcome data are limited by selection bias, as P4HB is preferentially used in complex and contaminated cases. - Source: PubMed
Publication date: 2026/09/16
Akkihal Kartik SDickerson Kelly MIttiruck AnyaOgola Gerald OWang ChristineIskander MazenLeeds Steven GWard Marc AAladegbami Bola - Poly-4-hydroxybutyrate (P4HB, e.g., GalaFLEX™) is a bioabsorbable matrix with a broad spectrum of indications in surgery. However, there is a lack of evidence and data on its utilization in Europe in the breast reconstruction setting. - Source: PubMed
Publication date: 2026/09/09
Oliinyk DmytroDiesch SophiaWiesmeier AnnaUnbehaun PhilippPagani AndreaEisenmann SilvanRüwe MarcBrebant VanessaPrantl LukasAnker Alexandra - Radiation-induced heart disease (RIHD) is a major late complication of thoracic radiotherapy. However, the mechanisms responsible for its long-term progression remain poorly understood. Conventional explanations, such as DNA damage, and oxidative stress, mainly focus on early radiation responses and fail to fully account for the prolonged latency and progressive myocardial remodeling observed in RIHD over years to decades. - Source: PubMed
Publication date: 2026/08/20
Zuo NaLi YalingYang Jun - Atopic dermatitis (AD) is an inflammatory skin disorder characterized by skin barrier impairment, chronic inflammation, and intense pruritus. Staphylococcus aureus (S. aureus) critically contributes to its pathogenesis; however, the mechanistic role of its virulence factor fibronectin-binding protein (FnBP) in keratinocytes remains poorly understood. This study used bibliometric analysis and quantitative proteomics to examine the relationship. We first performed a bibliometric analysis, revealing a sustained increase in publications on S. aureus and AD, peaking at 99 articles in 2023, with hotspots focused on skin barrier function, immune inflammation, and pediatrics. Quantitative proteomics was employed to investigate how FnBP reshapes the extracellular proteome and whether the anti-α5 integrin antibody P1D6 exerts interventional effects. HaCaT cells were stimulated with recombinant FnBP alone or in combination with P1D6, followed by data-independent acquisition (DIA)-based proteomic analysis of secretome changes. Proteomic analysis identified FnBP-induced differentially expressed proteins enriched in immune- and barrier-related pathways, including cell adhesion, cell junctions, and VEGFA-VEGFR2 signaling. P1D6 intervention significantly inhibited the secretome profile and identified 241 core responsive proteins, of which approximately 52% returned to baseline levels after intervention (P > 0.05). These proteins were primarily enriched in pathways governing protein homeostasis, folding, proteasomal degradation, and interleukin-7 signaling. Notably, P1D6 modulated the downregulation of ATP5F1B and P4HB, key effectors within the interleukin-7 pathway. This study demonstrates that FnBP remodels the keratinocyte secretome by disrupting protein homeostasis, consequently inducing barrier injury and chronic inflammation related to AD, which can be effectively blocked by P1D6. Combined with bibliometric trends and proteomic evidence, this study focuses on FnBP, an underexplored virulence factor, and provides novel insights into AD pathogenesis and therapeutic interventions. - Source: PubMed
Publication date: 2026/08/05
Xu ChangHu ZiyiLiu YixuanHuang JiashuoCao XueshanGuo Yang