IL-6, mouse recombinant
- Known as:
- Interleukin-6, mouse Rec.
- Catalog number:
- BC-280
- Product Quantity:
- 10 ug
- Category:
- -
- Supplier:
- kamyia
- Gene target:
- IL-6 mouse recombinant
Related genes to: IL-6, mouse recombinant
- Gene:
- CEBPB NIH gene
- Name:
- CCAAT enhancer binding protein beta
- Previous symbol:
- TCF5
- Synonyms:
- LAP, CRP2, NFIL6, IL6DBP, C/EBP-beta
- Chromosome:
- 20q13.13
- Locus Type:
- gene with protein product
- Date approved:
- 1991-02-27
- Date modifiied:
- 2018-02-23
- Gene:
- CEBPD NIH gene
- Name:
- CCAAT enhancer binding protein delta
- Previous symbol:
- -
- Synonyms:
- CRP3, CELF, C/EBP-delta, NF-IL6-beta
- Chromosome:
- 8q11.21
- Locus Type:
- gene with protein product
- Date approved:
- 1992-06-24
- Date modifiied:
- 2018-02-23
- Gene:
- ENTPD6 NIH gene
- Name:
- ectonucleoside triphosphate diphosphohydrolase 6
- Previous symbol:
- CD39L2, IL6ST2
- Synonyms:
- NTPDase-6, dJ738P15.3
- Chromosome:
- 20p11.21
- Locus Type:
- gene with protein product
- Date approved:
- 1998-03-20
- Date modifiied:
- 2019-02-28
- Gene:
- IL6 NIH gene
- Name:
- interleukin 6
- Previous symbol:
- IFNB2
- Synonyms:
- IL-6, BSF2, HGF, HSF
- Chromosome:
- 7p15.3
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2017-07-12
- Gene:
- IL6RP1 NIH gene
- Name:
- interleukin 6 receptor pseudogene 1
- Previous symbol:
- IL6RL1
- Synonyms:
- -
- Chromosome:
- 9q22.2
- Locus Type:
- pseudogene
- Date approved:
- 1991-08-18
- Date modifiied:
- 2014-11-19
Related products to: IL-6, mouse recombinant
Related articles to: IL-6, mouse recombinant
- Four new compounds, euryallactone A (1) and euryallactannins A-C (2-4), along with three known ellagitannins (5-7) were isolated from the shells of Euryale ferox Salisb. Their structures were elucidated using NMR, HR-ESI-MS, ECD, and single-crystal x-ray diffraction. Compounds 2-7 exhibited anti-inflammatory activity by inhibiting NO production and reducing the levels of the proinflammatory TNF-α and IL-6 in LPS-induced RAW264.7 macrophages. The structure-activity relationship of compounds 1-7 was preliminarily assessed. The findings from this study highlight the potential of ellagitannins from Euryale shells as anti-inflammatory agents and provide a chemical basis for further functional studies. Moreover, this study enriches the material basis of the shells of E. ferox Salisb. - Source: PubMed
Ren Meng-TingCheng Yan-XiaWang Ren-ZhongZhao Hong-SuZhou Wu-XiRen Ya-ShuoWu De-LingXu Feng-Qing - Neuroinflammation assumes a pivotal role in Alzheimer's disease (AD) pathogenesis. Long noncoding RNAs (lncRNAs) regulate neuroinflammation through a competitive endogenous RNA (ceRNA) mechanism. This study aimed to explore the mechanism of SNHG3/miR-128-3p/UBR5 axis in AD associated neuroinflammation. SNHG3, miR-128-3p, and UBR5 levels were recognized by reverse transcription - quantitative polymerase chain reaction (RT-qPCR). In vitro AD model was established by Aβ1-42 stimulation in human microglial cells HMC3 and neuronal cells SK‑N‑SH. Cell apoptosis was detected by flow cytometry. Enzyme - linked immunosorbent assay (ELISA) and oxidative stress indicators were used to evaluate the neuroinflammatory phenotype. Morris water maze (MWM) test assesses the spatial learning and memory abilities of amyloid precursor protein/presenilin 1 (APP/PS1) mice with AAV-si-SNHG3. Serum SNHG3 was clearly upregulated in AD patients, and negatively related to MMSE score (r = -0.691, P<0.001). SNHG3 had diagnostic potential for AD (AUC=0.847, 95% CI = 0.806-0.888, sensitivity=75.63%, specificity=76.88%). SNHG3 regulates UBR5 expression by sponges miR-128-3p. Silence of SNHG3 inhibited M1 polarization (reducing TNF-α, IL-6, and iNOS), promotes M2 polarization (increasing Arg1, IL-10, and TGF-β), inhibits IL-1β release, suppresses neuronal apoptosis, and mitigates oxidative stress damage (reducing MDA and increasing SOD) via miR-128-3p/UBR5 axis in Aβ-stimulated HMC3 cells. SNHG3 also contributes to Aβ‑induced neuronal apoptosis, inflammation, and oxidative stress in SK‑N‑SH cells. AAV-si-SNHG3 significantly enhances spatial learning and memory abilities of APP/PS1 mice, and inhibits neuroinflammation and oxidative stress in the hippocampus. This study is the first to elucidate that SNHG3 could regulate microglial polarization and neuroinflammation through the SNHG3/miR-128-3p/UBR5 axis. - Source: PubMed
Publication date: 2026/07/25
Zhu Xin-AnLu HuijieLiu YumeiXue XianleiLin Liangfeng - Generally, people who acquire infection with the COVID-19 virus exhibit a fever and respiratory illness. However, certain individuals also exhibit gastrointestinal (GIT) symptoms, involving anorexia, diarrhea, abdominal pain, nausea, and vomiting. This study aimed to quantify and assess serum interleukin 6 (IL-6) and fecal calprotectin (FC) in COVID-19-positive individuals who exhibit diarrhea and other GIT symptoms as indicators of inflammation in the intestinal tract. The investigation included 80 cases with diarrhea and other GIT symptoms. They were divided into two groups: group A (cases) consisted of 40 COVID-19 patients with GIT symptoms and group B (controls) consisted of 40 COVID-19 patients without GIT symptoms. Serum IL-6 and FC were assessed in both groups. The most effective cut-off value for predicting intestinal inflammation was >63, with a sensitivity of 67.5% and a specificity of 65%. The most effective cut-off value for predicting intestinal inflammation was >194, with a sensitivity of 87.6% and a specificity of 77.3%. Although the FC was more significant than serum IL-6, the difference in the area under curve (AUC) was insignificant (0.075; z-test= 1.632, p>0.05). In COVID-19 cases with experienced intestinal symptoms, serum IL-6 and FC were increased. - Source: PubMed
Alashram Mohamed N BAlrefaey Alsaied AEl Nakeeb Noah AKhyal Ahmed EAhmed Ahmed EGuirguis Reginia N M - Chronic hepatitis C virus (HCV) infection is associated with prolonged immune activation and systemic inflammation, which may be reflected in circulating immune mediators. Defensins and cytokines have emerged as potential biomarkers for monitoring immune dysregulation in chronic viral hepatitis. This study aimed to monitoring serum levels of human α-defensin-1 (HAD-1) and human β-defensin-1 (HBD-1) with selected cytokines (IL-6, IL-28, TNF-α, and IFN-) in Iraqi patients with chronic HCV and to evaluate their diagnostic performance by the receiver operating characteristic (ROC) analysis. This cross-sectional case-control study was conducted in Iraq during February-November 2025. It included 100 laboratory-confirmed chronic HCV patients and 50 normal controls. Serum HAD-1, HBD-1, IL-6, IL-28, TNF-α, and IFN- were measured by ELISA. Hematological indices and liver function markers were also analyzed. HCV patients showed significantly increased HAD-1 and HBD-1 levels compared with controls (p< 0.01). Cytokine profiling revealed markedly elevated IL-6, IL-28, TNF-α, and IFN- levels in patients, indicating strong activation of inflammatory and antiviral immune pathways (p<0.01). ROC curve analysis demonstrated excellent diagnostic performance of defensins and cytokines to distinguish chronic HCV patients from controls, with area under the curve values ranging from 0.849 to 0.950 units. In conclusion, the circulation of defensins and inflammatory cytokines is markedly up-regulated in chronic HCV and has high diagnostic utility indicating their potential as immune biomarkers for chronic HCV-related inflammation and immune dysregulation. - Source: PubMed
Enad Ahmed TJassim Al-Zahraa JAlwandawi Thuraya KAbbas Ruqaya K - pneumonia (MPP) is a pulmonary inflammatory disease caused by (Mp) infection that primarily involves the bronchi, alveoli, and pulmonary interstitium. It is the most common cause of community-acquired pneumonia in children. Andrographolide (AG) is a natural diterpenoid lactone with anti-inflammatory and immunomodulatory activities; however, its specific role and mechanism in MPP remain unclear. - Source: PubMed
Publication date: 2026/05/19
Zhang LijuanSaeed UmarGao Rui