RAB9B Antibody
- Known as:
- RAB9B Antibody
- Catalog number:
- GWB-MU579C
- Product Quantity:
- 50ug
- Category:
- -
- Supplier:
- GenWay
- Gene target:
- RAB9B Antibody
Related genes to: RAB9B Antibody
- Gene:
- RAB9B NIH gene
- Name:
- RAB9B, member RAS oncogene family
- Previous symbol:
- -
- Synonyms:
- RAB9L
- Chromosome:
- Xq22.2
- Locus Type:
- gene with protein product
- Date approved:
- 2002-02-28
- Date modifiied:
- 2015-02-16
Related products to: RAB9B Antibody
Related articles to: RAB9B Antibody
- Growing insights into gut microbiota reveal their surprising role in shaping external traits in fish, including the regulation of skin pigmentation. This study explores whether black-spot pigmentation influences the abundance of gut microbiota. We investigate how black-spot pigmentation in Oujiang color common carp shapes gut microbiome composition, gene expression, and metabolite, revealing a coordinated gut-skin color axis. To validate these findings, we used a TYR knockout group, which included both mutant black-spotted (TYR ) and non black-spotted (TYR ) fish, enabling functional comparison across pigmentation phenotypes. - Source: PubMed
Publication date: 2025/10/02
Kanika N HKe JMandal R NGuo Z YCai S LHou XChen X WWang JWang C H - The tumor microenvironment (TME) exerts a profound influence on the progression, therapeutic responses, and clinical outcomes of acute myeloid leukemia (AML), a prevalent hematologic malignancy in adults. This study aimed to establish a TME-based prognostic model to unveil novel therapeutic and prognostic avenues for AML. - Source: PubMed
Publication date: 2025/07/03
Navidinia Amir AbbasKhayami RezaGholami AlirezaFathi MahnazKeshavarz AliKarami NajibeAlipanah HiradAhmadi AliRostami ShahrbanoChahardouli Bahram - Sex differences in Parkinson's disease (PD) risk are well-known. However, the role of sex chromosomes in the development and progression of PD is still unclear. - Source: PubMed
Publication date: 2023/07/20
Leal Thiago PRao Shilpa CFrench-Kwawu Jennifer NGouveia Mateus HBorda VictorBandres-Ciga SaraInca-Martinez MiguelMason Emily AHorimoto Andrea R V RLoesch Douglas PSarihan Elif ICornejo-Olivas Mario RTorres Luis EMazzetti-Soler Pilar ECosentino CarlosSarapura-Castro Elison HRivera-Valdivia AndreaMedina Angel CDieguez Elena MRaggio Víctor ELescano AndrésTumas VitorBorges VanderciFerraz Henrique BRieder Carlos RSchumacher Schuh ArturSantos-Lobato Bruno LVelez-Pardo CarlosJimenez-Del-Rio MarleneLopera FranciscoMoreno SoniaChana-Cuevas PedroFernandez WilliamArboleda GonzaloArboleda HumbertoArboleda Bustos Carlos EYearout DoraBarbosa Maira TCardoso Francisco E CCaramelli PauloCunningham Mauro C QMaia Débora PLima-Costa Maria FTarazona-Santos EduardoZabetian Cyrus P Thornton Timothy AO'Connor Timothy DMata Ignacio F - Sex differences in Parkinson Disease (PD) risk are well-known. However, it is still unclear the role of sex chromosomes in the development and progression of PD. We performed the first X-chromosome Wide Association Study (XWAS) for PD risk in Latin American individuals. We used data from three admixed cohorts: (i) Latin American Research consortium on the GEnetics of Parkinson's Disease (n=1,504) as discover cohort and (ii) Latino cohort from International Parkinson Disease Genomics Consortium (n = 155) and (iii) Bambui Aging cohort (n= 1,442) as replication cohorts. After developing a X-chromosome framework specifically designed for admixed populations, we identified eight linkage disequilibrium regions associated with PD. We fully replicated one of these regions (top variant rs525496; discovery OR [95%CI]: 0.60 [0.478 - 0.77], p = 3.13 × ; replication OR: 0.60 [0.37-0.98], p = 0.04). rs525496 is an expression quantitative trait loci for several genes expressed in brain tissues, including and . We also replicated a previous XWAS finding (rs28602900), showing that this variant is associated with PD in non-European populations. Our results reinforce the importance of including X-chromosome and diverse populations in genetic studies. - Source: PubMed
Publication date: 2023/02/02
Leal Thiago PFrench-Kwawu Jennifer NGouveia Mateus HBorda VictorInca-Martinez MiguelMason Emily AHorimoto Andrea RvrLoesch Douglas PSarihan Elif ICornejo-Olivas Mario RTorres Luis EMazzetti-Soler Pilar ECosentino CarlosSarapura-Castro Elison HRivera-Valdivia AndreaMedina Angel CDieguez Elena MRaggio Víctor ELescano AndrésTumas VitorBorges VanderciFerraz Henrique BRieder Carlos RSchumacher-Schuh ArturSantos-Lobato Bruno LVelez-Pardo CarlosJimenez-Del-Rio MarleneLopera FranciscoMoreno SoniaChana-Cuevas PedroFernandez WilliamArboleda GonzaloArboleda HumbertoArboleda Bustos Carlos EYearout DoraLima-Costa Maria FTarazona EduardoZabetian CyrusThornton Timothy AO'Connor Timothy DMata Ignacio F - Hemophagocytic lymphohistiocytosis (HLH), particularly primary HLH (pHLH), is a rare, life-threatening disease. Germline genetic deficiency of 12 known HLH genes impairs cytotoxic degranulation in natural killer (NK) cells or cytotoxic T lymphocytes (CTLs) and contributes to pHLH development. However, no pathogenic mutations in these HLH genes are found in nearly 10% of HLH patients, despite a strong suspicion of pHLH, suggesting that the underlying genetic basis of HLH is still unclear. To discover novel susceptibility genes, we first selected 13 children with ppHLH (presumed primary HLH patients in the absence of detectable known HLH gene variants) and their parents for initial screening. Whole-genome sequencing (WGS) in one trio and whole-exome sequencing (WES) in twelve trios revealed that two ppHLH patients carried biallelic NBAS variants, a gene that is involved in Golgi-to-endoplasmic reticulum (ER) retrograde transport upstream of the degranulation pathway. Additionally, two candidate genes, RAB9B and KLC3, showed a direct relationship with known HLH genes in protein-protein interaction (PPI) network analysis. We analyzed NBAS, RAB9B, KLC3 and known HLH genes in an independent validation cohort of 224 pediatric HLH patients. Only biallelic NBAS variants were identified in three patients who harbored no pathogenic variants in any of the known HLH genes. Functionally, impaired NK-cell cytotoxicity and degranulation were revealed in both NBAS biallelic variant patients and in an NBAS-deficient NK-cell line. Knockdown of NBAS in an NK-cell line (IMC-1) using short hairpin RNA (shRNA) resulted in loss of lytic granule polarization and a decreased number of cytotoxic vesicles near the Golgi apparatus. According to our findings, NBAS is the second most frequently mutated gene (2.11%) in our HLH cohort after PRF1. NBAS deficiency may contribute to the development of HLH via a dysregulated lytic vesicle transport pathway. - Source: PubMed
Publication date: 2022/07/28
Bi XiaomanZhang QingChen LeiLiu DanLi YueyingZhao XiaoxiZhang YaZhang LipingLiu JingkunWu ChaoyiLi ZhigangZhao YunzeMa HonghaoHuang GangLiu XinWang Qian-FeiZhang Rui