GNAO1 Antibody
- Known as:
- GNAO1 Antibody
- Catalog number:
- GWB-MT839B
- Product Quantity:
- 50ug
- Category:
- -
- Supplier:
- GenWay
- Gene target:
- GNAO1 Antibody
Related genes to: GNAO1 Antibody
- Gene:
- GNAO1 NIH gene
- Name:
- G protein subunit alpha o1
- Previous symbol:
- -
- Synonyms:
- G-ALPHA-o
- Chromosome:
- 16q13
- Locus Type:
- gene with protein product
- Date approved:
- 1988-04-24
- Date modifiied:
- 2016-03-03
Related products to: GNAO1 Antibody
Related articles to: GNAO1 Antibody
- Neuropathic pain is a debilitating condition with limited effective treatments, highlighting an urgent need for non-opioid analgesic targets. Gαo, encoded by the Gnao1 gene, is an abundant G protein in the nervous system and couples to multiple inhibitory GPCRs, but its role in chronic pain remains poorly understood. - Source: PubMed
Publication date: 2026/06/23
Cai JieyiLi HuiChen LüLuo LingWu XinYuan MinHan MaolinWen ShirongZhu ChanglaiGu Yun - Epilepsy is a heterogeneous neurological disorder characterized by recurrent, unprovoked seizures, with genetic factors playing a major role in its etiology, particularly in consanguineous populations where recessive variants are more prominent. - Source: PubMed
Publication date: 2026/06/18
Ali QaisarAzam SadiqJaved JamilaZaheer MuhammadUllah SaqibIqbal AqibKhan IbrarRehman Shoaib Ur - Childhood-onset dystonia (COD) encompasses a clinically and etiologically heterogeneous group of disorders, often with overlapping features. Genetic testing plays a pivotal role in uncovering underlying causes, identifying treatable subtypes, and informing individualized management strategies. - Source: PubMed
Publication date: 2026/06/16
Yilmaz SanemSerdaroglu EsraSimsek ErdemKara BulentTurkdogan DilsadYis UlucErol IlknurYuksel DenizKanmaz SedaEroglu ArzuCanpolat MehmetKomur MustafaCıtak Kurt NeseSakarya Gunes AyferSoydemir DidemBesen SeydaBektas OmerKirik SerkanAtalay Celik HaleArdicli DidemAksoy AyseYarar CoskunCerci Kubur CisilOlgac Dundar NihalGungor OlcayKamasak TulayOlculu Cemile BusraGumus HakanYildirim MiracIsik EsraAtik TahirCogulu OzgurBasak Ayse NazliSunnetci Akkoyunlu DenizÖzbakır Derya HazalKayhan GülsümGerik Çelebi Hamide BetulKaraer KadriDundar MunisKaiyrzhanov RauanCeylaner SerdarPer HuseyinHiz Ayse SemraCansu AliOkuyaz CetinAnlar BanuTekgul Hasan - GNAO1-related disorder (GNAO1-RD) is ultra-rare and clinically heterogeneous. Often, children with GNAO1-RD have (severe) motor impairments, which may lead to an underestimation of their communication abilities. To help these children achieve their full potential in daily life, it is essential to understand their communicative abilities and limitations. In this study, we aimed to investigate spoken language comprehension (SLC), speech and functional communication. - Source: PubMed
Publication date: 2026/06/05
Heideman Larissa RGeytenbeek JohannaWolf Nicole IBuizer Annemieke Ivan de Pol Laura A - G protein-coupled receptors (GPCRs) enable chemical communication between cells and are involved in nearly all essential functions. They transduce signals via heterotrimeric G proteins and are regulated by internalization, a process which redirects them from the cell surface to internal compartments and enables diversified signaling through spatial reorganization. Beyond the receptor, a vast regulatory network exists to further control G-protein signaling. However, it is unclear whether these modes of G-protein regulation also impact the upstream GPCR. Here, we systematically address how G-protein cycle regulation shapes GPCR internalization and establish several key principles and mechanisms governing this process. We find that timing of G-protein activation and deactivation and changes in G-protein cycle lifetime imparted by guanine nucleotide exchange factors, activators of G-protein signaling, and regulators of G-protein signaling can alter internalization outcomes. Furthermore, we determine how the activity and balance of discrete G-protein components interact with the G protein-coupled receptor kinase system to influence GPCR spatial distribution. Finally, we uncover that disease-associated variants of the most abundant G protein in the brain, GαoA, affect the regulatory network that drives GPCR internalization. Altogether, this study reveals that GPCR internalization is not a fixed receptor property but is dynamically governed by receptor-G-protein activation order, cycle lifetime, and the balance of Gα and Gβγ availability. As such, alterations in receptor internalization dynamics may contribute to the complex disease phenotypes associated with dysregulated G-protein networks. - Source: PubMed
Publication date: 2026/06/09
Rowe Jacob BPandey ShubhiMayer Ryan ALudlam W GrantDrube JuliaInoue AsukaHoffmann CarstenMartemyanov Kirill A