LAX1 Antibody
- Known as:
- LAX1 Antibody
- Catalog number:
- GWB-MQ729I
- Product Quantity:
- 50ug
- Category:
- -
- Supplier:
- GenWay
- Gene target:
- LAX1 Antibody
Related genes to: LAX1 Antibody
- Gene:
- LAX1 NIH gene
- Name:
- lymphocyte transmembrane adaptor 1
- Previous symbol:
- -
- Synonyms:
- LAX, FLJ20340
- Chromosome:
- 1q32.1
- Locus Type:
- gene with protein product
- Date approved:
- 2005-04-25
- Date modifiied:
- 2014-11-19
Related products to: LAX1 Antibody
Related articles to: LAX1 Antibody
- Modern rice breeding faces the critical challenge of simultaneously improving yield, grain quality, and stress tolerance to meet sustainable production demands. This study systematically investigated the molecular mechanisms underlying high yield, superior quality, and heat tolerance in the thermo-sensitive genic male sterile line Gong 887 S, its restorer lines (Yuenongsimiao, Jingguizhan and YR592), and their hybrid combinations through an integrated approach combining whole-genome sequencing, functional gene analysis, and phenotypic characterization. The high-quality Gong 887 S genome assembly (LAI = 26.52, BUSCO = 98%) revealed 40,564 protein-coding genes and a remarkable 6.38% japonica introgression, substantially exceeding the < 3% typically found in indica varieties. Functional analysis identified key regulatory genes (, , ) on Chrs (chromosomes) 1, 3, and 7 that coordinately enhance panicle architecture, grain morphology, and thermotolerance. Hybrid combinations accumulated 56-83 favorable alleles (including , , , and ), demonstrating significant yield advantages (9,714-9,841 kg/ha, + 2.6-8.1%) across multiple locations. Notably, these hybrids maintained robust performance under heat stress, with seed-setting rates of 56.80-66.01% under controlled 40 °C conditions and > 85% in field trials. Grain quality analysis revealed premium characteristics: head rice rate (68.7-72.0%), chalkiness (1.0-1.9%), and amylose content (15-17%). Structural variations (chromosome inversion and chromosome 11 deletion) were found to regulate and expression, simultaneously increasing protein content (+ 8.3%) and reducing chalkiness (-42.9%). By elucidating the genetic networks of Gong 887 S and its hybrids, this study highlights the substantial contributions of indica-japonica introgression, multi-gene synergy, and structural variations to trait improvement, providing a robust theoretical foundation for molecular design breeding in rice. - Source: PubMed
Publication date: 2026/08/18
Yu JianghuiYan QiupingZhang GuowenYang QinghuaDeng YanyanSun XingqiangLin YongLiao TianyiKang FuliPeng YunpengLiu SongDu JuanTang WenbangZhang Yangjun - Crohn's disease (CD) is a chronic inflammatory bowel disease marked by immune imbalance and monocyte dysfunction. IFITM3, a palmitoylation-related immune protein, may play a role in this process, but its involvement in CD remains unclear. This study aimed to explore the causal role of IFITM3 and related proteins in CD using Mendelian randomization, multi-omics analysis, and machine learning, to identify potential diagnostic markers and therapeutic targets. - Source: PubMed
Publication date: 2026/06/04
Song XinxiaYuan TangyuXing JiayinLiu Pengtao - The development of axillary meristems (AMs) is critical for tillering and panicle branching in rice, processes that ultimately determine grain yield. LAX PANICLE1 (LAX1) encodes a basic helix-loop-helix (bHLH) transcription factor essential for AM formation during panicle development. However, because LAX1 possesses a non-canonical basic region that contains fewer than five basic amino acids, it has long been presumed to lack intrinsic DNA-binding capacity, leaving its molecular mechanism of action unclear. Here, we demonstrate that LAX1 localizes to the nucleus and exhibits transcriptional activation activity. Using systematic evolution of ligands by exponential enrichment (SELEX) assays, we found that LAX1 possesses intrinsic DNA-binding capability in vitro. Furthermore, chromatin immunoprecipitation sequencing (ChIP-seq) analysis of young rice panicles identified direct LAX1 target genes; peaks were significantly enriched for the motif TTTTGC(T/A/C)NNN(G/A/T), which is directly recognized by the LAX1 bHLH domain. Subsequent experiments showed that LAX1 directly binds to the promoters of OsPID, OsIAA7, LOG, and OsTPS8. Molecular and genetic analyses provided evidence supporting a functional role for the LAX1-OsPID module in the regulation of inflorescence architecture. Comparative transcriptome analysis of lax1 mutants and wild-type plants further indicated that LAX1 participates in multiple biological processes. Interestingly, we found that LAX1 and its orthologs likely regulate downstream gene expression by recognizing a common set of cis-regulatory elements across diverse cereal crops. Collectively, our findings redefine LAX1 and its orthologs as canonical bHLH transcription factors, elucidate the regulatory network through which they control panicle branching, and provide a theoretical foundation for the cross-species application of LAX1 in crop yield improvement. - Source: PubMed
Publication date: 2026/05/25
Fu DebaoXiong XiaohuWei MinghuaGao TianXu TingtingZhu JunkaiMa ShuaiguoZhu ChunmeiKong QiushengWu Changyin - BACKGROUND: Drought is a major constraint to rice (Oryza sativa L.) yield. The young spike differentiation stage is crucial for yield determination, exhibiting heightened sensitivity to soil moisture deficits. RICE CENTRORADIALIS 1 (RCN1), a TERMINAL FLOWER-like gene, is a key regulator of young spike differentiation and may mediate drought-induced delays in floral transition in rice. This study examines the effect of drought stress during the young spike differentiation stage on rice spike structure and investigates the role of RCN1 in this process. RESULTS: Drought stress markedly suppresses branch differentiation, especially secondary branches. Compared to the wild type (WT), the spike structure of rcn1 mutants was more severely compromised under drought conditions, the ABA-mediated protection of spike structure was also reduced in the rcn1 mutants. Key flowering regulators, Ehd1 and Hd1, were implicated in the regulation of young spike differentiation under drought stress, with the drought response of Ehd1 negatively modulated by RCN1. Furthermore, RCN1 influenced the expression of branch-promoting genes, including LAX1, RCN2 and RCN4 under drought. RCN1 displayed high sensitivity in rice roots, the increase rate of new roots in rcn1 mutants was lower than in WT under 10% PEG-6000 treatment. Under 15% PEG-6000 treatment, rcn1 mutants showed lower survival rate and ABA content compared to WT. CONCLUSIONS: RCN1 contributes to the maintenance of spike structure under drought stress by promoting second branch formation and affecting the drought response of some spike differentiation-related genes (Ehd1, LAX1, RCN2 and RCN4). Additionally, RCN1 enhances drought tolerance of rice by promoting abscisic acid (ABA) biosynthesis and facilitating new root germination, thereby indirectly reducing yield losses. - Source: PubMed
Publication date: 2026/04/13
Feng XinyiZhong XintongWen JiaminLiu YuWang YanZha Manrong - Pancreatic cancer remains highly lethal, largely due to late diagnosis and limited efficacy of treatments. Improving first-line treatment selection and patient monitoring requires novel, non-invasive biomarkers beyond carbohydrate antigen 19-9 (CA19-9) and imaging. This study investigates epigenetic biomarkers from liquid biopsy with prognostic and predictive potential in metastatic pancreatic ductal adenocarcinoma (PDAC; mPDAC). Genome-wide methylation profiling of cell-free DNA (cfDNA) from healthy individuals and stage IV mPDAC patients identified 13 gene-associated CpG sites with significantly altered methylation patterns. ddPCR validation confirmed consistent methylation differences in lymphocyte transmembrane adaptor 1 (), nuclear receptor subfamily 3 group C member 1 (), and between healthy and patient groups. Elevated and methylation and reduced methylation at diagnosis were associated with poor prognosis and correlated with high-risk circulating biomarker profiles, including CA19-9 levels, MAF (mutant allele fraction), cfDNA concentration, and cfDNA fragmentation. Notably, baseline methylation levels predicted response to first-line FOLFIRINOX-based treatment with an acceptable 75% sensitivity and a high specificity of 92.86%. These findings highlight the clinical significance of cfDNA methylation as a minimally invasive biomarker source, emphasizing , , and as prognostic biomarkers in mPDAC. Specifically, baseline methylation emerges as a promising predictor of treatment response, supporting personalized therapeutic strategies in mPDAC. - Source: PubMed
Publication date: 2026/03/22
Cano-Ramírez PabloToledano-Fonseca MartaCano-Osuna María TeresaHerrera-Casanova NereaCarrillo-Pecero EmilioRodríguez-Ariza AntonioAranda EnriqueGarcía-Ortiz María Victoria