CCNB3 Antibody
- Known as:
- CCNB3 Antibody
- Catalog number:
- GWB-MN196G
- Product Quantity:
- 50ug
- Category:
- -
- Supplier:
- GenWay
- Gene target:
- CCNB3 Antibody
Related genes to: CCNB3 Antibody
- Gene:
- CCNB3 NIH gene
- Name:
- cyclin B3
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- Xp11.22
- Locus Type:
- gene with protein product
- Date approved:
- 2002-05-30
- Date modifiied:
- 2016-10-05
Related products to: CCNB3 Antibody
Related articles to: CCNB3 Antibody
- Soft tissue sarcomas (STSs) are a heterogeneous group of rare mesenchymal malignancies with overlapping morphological and immunohistochemical features, often making definitive diagnosis challenging. Recent advances in next-generation sequencing (NGS) have enabled the identification of recurrent molecular alterations that contribute to tumor classification, prognostic stratification, and precision oncology approaches. This retrospective study aimed to evaluate the diagnostic and clinical impact of molecular profiling in pediatric soft tissue sarcomas using the Oncomine Childhood Cancer Research Assay (OCCRA) panel. Fifty-five frozen tumor samples representing 24 distinct soft tissue sarcoma subtypes were obtained from the Pediatric Oncology Institute -IOP/GRAACC/UNIFESP Biobank (B-053). Molecular analysis was performed using NGS to identify gene fusions, single nucleotide variants (SNVs), copy number variations (CNVs), and insertions/deletions (InDels). Clinically relevant molecular alterations were identified in 70% (37/55) of cases, including 18 fusion transcripts, 13 SNVs, 8 CNVs, and 6 InDels. Recurrent and diagnostically relevant alterations included ::, ::, :, ::, ::, ::, ::, :: and :: fusions, as well as amplifications involving , , , , , and . Pathogenic variants affecting genes involved in tumor suppression and chromatin remodeling, including , , , , , and , were also detected. Importantly, molecular profiling had significant diagnostic impact in several histologically ambiguous tumors, enabling molecular reclassification and refinement of previously inconclusive or inaccurate pathological diagnoses. In multiple cases, NGS transformed descriptive histopathological interpretations into genetically defined sarcoma entities, including -rearranged spindle cell neoplasms, -rearranged sarcomas, synovial sarcoma, low-grade fibromyxoid sarcoma, and clear cell sarcoma. Furthermore, the identification of actionable alterations highlighted potential opportunities for targeted therapies and precision medicine approaches. Our findings demonstrate that comprehensive molecular profiling significantly enhances diagnostic accuracy in pediatric soft tissue sarcomas, particularly in morphologically challenging cases. The integration of NGS into routine sarcoma diagnostics enables biologically informed tumor classification and supports personalized therapeutic strategies. - Source: PubMed
Publication date: 2026/08/12
Tesser-Gamba FrancineMendes Thais BiudeLima Fernanda TeresaAbib Simone de Campos VieiraCaran Eliana Maria MonteiroToledo Silvia Regina Caminada de - fusion-positive sarcoma (BCS) is a recently recognized subtype of undifferentiated round-cell sarcoma that occurs predominantly in children and adolescents. Owing to its rarity, an optimal treatment strategy has not been fully established, and management has historically followed treatment protocols for Ewing sarcoma. Although radiotherapy is a potential treatment option, the role of carbon-ion radiotherapy (CIRT) in treating this tumor has not been previously reported. A 14-year-old boy presented with posterior neck pain. Magnetic resonance imaging demonstrated a tumor arising from the posterior elements of the third cervical vertebra. Needle biopsy revealed a round-cell sarcoma without EWS gene rearrangement, and the patient was initially treated for Ewing-like sarcoma. Systemic chemotherapy with vincristine, doxorubicin, and cyclophosphamide alternating with ifosfamide and etoposide was initiated, resulting in tumor shrinkage. Subsequently, the patient underwent CIRT (70.4 Gy in 16 fractions), followed by adjuvant chemotherapy. Magnetic resonance imaging after treatment completion showed no evidence of residual tumor. More than 12 years after treatment, the patient has remained asymptomatic without neurological deficits, tumor recurrence, or distant metastasis, although cervical kyphosis was radiographically observed. Subsequent genetic analysis confirmed the presence of the fusion gene. To the best of our knowledge, this is the first reported case of BCS treated with CIRT. This case demonstrates that CIRT can achieve durable local control and suggests that it may represent a promising treatment option for BCS when surgical resection is challenging. - Source: PubMed
Publication date: 2026/06/10
Oike NaokiImai ReikoOgose AkiraAriizumi TakashiMurayama YudaiMiyazaki TomohiroKimura KazunagaUmezu HajimeKawashima Hiroyuki - Invertebrates rely exclusively on innate immunity but exhibit memory-like responses termed immune priming or trained immunity. In the commercially vital whiteleg shrimp (), infection by causes severe economic losses, yet the molecular networks driving secondary immune recall remain poorly understood. In this study, we established a two-step immune challenge model in using formaldehyde-inactivated and performed transcriptomic analysis on hemocytes to compare primary and secondary immune responses. Differentially expressed gene (DEG) screening and enrichment analyses (GO, KEGG, and GSEA) suggest that shrimp hemocytes undergo a broad and coordinated transcriptional reprogramming rather than uniform upregulation of immune genes. Transcriptomic data show potential associations between secondary immune priming and the modulation of cell fate processes: genes related to cell cycle progression (e.g., CDK1, CCNB3) and spindle assembly (e.g., MPS1) were significantly upregulated alongside apoptosis inhibition (CASP6 downregulation). Concurrently, metabolic remodeling was observed through the upregulation of lipid synthesis (SREBF1, FASN) and carbohydrate uptake pathways, potentially providing anabolic support for hemocyte growth and immune activation. Furthermore, the humoral effector responses appear to be strengthened, characterized by upregulated antimicrobial peptides (PEN, ALF) and the proPO melanization cascade (PPAF3, PPO3), whereas the expression of intracellular NLR was relatively suppressed, which might help mitigate excessive immune inflammation and immunopathological damage. Collectively, these transcriptomic findings identify a putative coordinated transcriptional signature of hemocyte recall responses in . This study expands our understanding of innate immune memory in invertebrates and provides candidate molecular markers for further study in disease-resistant breeding research in shrimp aquaculture. - Source: PubMed
Publication date: 2026/06/18
Li ZhongyingLi ShihaoLv XinjiaLi Fuhua - Isoginkgetin (ISO) is a natural flavonoid with potential anticancer effects. However, the anticancer mechanisms of ISO in gastric cancer remain insufficiently explored. - Source: PubMed
Li LinenZhu HuilingCao KunChen Hao - Cuproptosis, a newly discovered form of copper-driven regulated cell death, has been shown to be closely related to ovarian function. However, whether the oocyte dysfunction, decreased ovulation efficiency, and cumulus cell aging caused by copper overload or imbalance are associated with regulatory pathways related to cuproptosis remains unclear. In this study, the expression profiles of genes related to cuproptosis in cumulus cells were comprehensively analyzed through transcriptome sequencing and metabolome analysis, and key genes and pathways that affect oocyte maturation were identified in response to elesclomol and CuSO treatment. Transcriptome analysis of cumulus cells revealed the differential expression of genes involved in key biological processes, such as cellular senescence (AKT3, MORC3, RBL1, etc.), gap junctions (GJA1, GNAI1, GJB3, etc.), steroid biosynthesis (FDX1, HSD17B7, CYP1A1, etc.), and cell cycle regulation (CDK2, CCNB2, MAPK7, etc.). Metabolomic analysis revealed significant changes in the levels of malic acid, PS (18:3(10,12,15)-OH(9)/14:0), and PA (21:0/LTE4), among other compounds. Subsequent Smart-seq analysis of oocytes revealed that after cuproptosis was induced in cumulus cells, oocyte maturation was disrupted, which affected genes associated with cellular senescence (TGFB2, SIRT1, CHEK2, etc.), oocyte meiosis (FBXO5, CCNB3, PLK1, etc.), and DNA methylation (PPM1D, DNMT3B, KMT2A, etc.). These findings provide deeper theoretical support for the key genes and biological processes involved in cumulus cell regulation and oocyte maturation, further clarifying the regulatory mechanisms of cuproptosis in the field of reproduction. - Source: PubMed
Publication date: 2026/05/05
Xu HongTian TianXu DanDu XiaoxueSu RuiLiang JinghongLiu YingZhang YuqingLiu ChangLiang ShuangLi QingyingDing DeliHan YongshengZhai BoLi JidongChen ChengzhenZhang JiabaoJiang HaoYuan Bao