ZFP57 Antibody
- Known as:
- ZFP57 Antibody
- Catalog number:
- GWB-C493B3
- Product Quantity:
- 0.1 mg
- Category:
- -
- Supplier:
- GenWay
- Gene target:
- ZFP57 Antibody
Related genes to: ZFP57 Antibody
- Gene:
- ZFP57 NIH gene
- Name:
- ZFP57 zinc finger protein
- Previous symbol:
- C6orf40
- Synonyms:
- ZNF698, bA145L22, bA145L22.2
- Chromosome:
- 6p22.1
- Locus Type:
- gene with protein product
- Date approved:
- 2003-11-26
- Date modifiied:
- 2018-11-22
Related products to: ZFP57 Antibody
Related articles to: ZFP57 Antibody
- The biological mechanisms linking generalized anxiety disorder (GAD) and COVID-19 remain poorly understood, despite substantial evidence of their comorbidity. To address this gap, we examined genetic and epigenetic factors underlying their co-occurrence. - Source: PubMed
Publication date: 2026/06/04
Karaca SefayetCabrera Mendoza BrendaHe JunQiu DanDavtian DavidLacobelle AnnMarieNunez Yaira ZKrystal John HPietrzak Robert HGelernter JoelPolimanti Renato - Can single-cell, mass spectrometry-based proteomics identify proteins associated with reduced developmental competence of Patl2-/- Metaphase II (MII) mouse oocytes and reveal therapeutic targets for Patl2-related infertility? - Source: PubMed
Publication date: 2026/05/01
Cardona Barberán AAraftpoor EChristodoulaki AFakhar-I-Adil MGoethals JRybouchkin AArnoult CBoel ABühler MPavani K CStoop DGevaert KVanden Meerschaut FHeindryckx B - Complex neural activity in the mammalian central nervous system are achieved through the coordinated function of diverse neuronal subtypes. The sequential generation of distinct types of neurons from neural progenitor cells during development is a key process in establishing this complexity. However, how this temporal specification of neuronal identities is regulated across different brain regions during development remains only partially understood. Here, we identify PHF21B, ZFP7, and ZFP57 as critical regulators that control the transition from the generation of early-born to late-born neurons by neural progenitor cells in the developing mouse cortex and ganglionic eminence. Combinatorial overexpression of these factors in developmentally advanced progenitors that normally generate late-born neurons led to a prolonged generation of early-born neuronal subtypes. Conversely, simultaneous knockdown of these genes markedly reduced generation of early-born neurons. Because these factors are predicted to function as transcriptional regulators involved in heterochromatin formation at their target genomic loci, our findings suggest the presence of a shared epigenetic mechanism that governs the temporal specification of neurons across multiple regions of the developing brain. - Source: PubMed
Publication date: 2026/04/16
Hisamatsu DaisukeHasegawa HiroyukiNaka-Kaneda HayatoNakajima KazunoriOkano HideyukiShimazaki Takuya - Papillary thyroid carcinoma (PTC) undergoes dedifferentiation into aggressive poorly differentiated (PDTC) or anaplastic (ATC) carcinomas in 10–15% of cases, a process potentially driven by cancer-associated fibroblasts (CAFs) within the tumor microenvironment (TME), though their spatiotemporal dynamics remain poorly understood. Resveratrol (Res), a natural compound, has shown anticancer potential by promoting redifferentiation and apoptosis while inhibiting oncogenic signaling, suggesting utility in countering PTC dedifferentiation. Using spatial transcriptomics (10× Visium) on three surgical specimens, we obtained 14,191 high-quality spots annotated via UMAP and Leiden clustering into seven cell types, including CAFs, T cells, B cells, and others. Comparative gene expression and functional enrichment analyses revealed CAFs in poorly differentiated regions exhibited heightened glycolytic activity, correlated with ZFP57 upregulation and PKM2 induction. Glycolysis was validated through immunofluorescence, Seahorse assays, glucose/lactate measurements, and ZFP57-PKM2 reporter assays. CAF-conditioned media promoted PTC proliferation, invasion, and dedifferentiation while reducing radioiodine uptake in co-culture models. In xenografts, ZFP57 overexpression increased tumor growth and impaired radioiodine retention, whereas Res suppressed ZFP57, restored differentiation, enhanced radioiodine avidity, and inhibited glycolysis. Mechanistically, CAF-secretated lactate activated TGF-β/Smad2/3 signaling, fostering dedifferentiation and malignancy. Resveratrol reversed these effects by targeting ZFP57, normalizing CAF metabolism, and restoring PTC differentiation, indicating a promising therapeutic strategy against PTC progression. - Source: PubMed
Publication date: 2026/02/27
Ji XiaoyuLv ChengzhouWu XianWu HongpengChang YuangLiu QiDong WenwuHuang JiapengZhang DalinDiao YaoSun DapengWang ZhihongZhang PingSun WeiZhang Hao - Early-life factors, including postnatal nutrition, shape long-term health outcomes with epigenetic effects being implicated but poorly understood in the process. Zinc-finger protein 57 (ZFP57), is an epigenetic regulator of genomic imprinting, a process controlling gene expression based on parental origin with a vital role in prenatal growth. Here, we report an imprinting-independent function of ZFP57 in postnatal resource control via the mammary gland. ZFP57 influences multiple mammary gland phenotypes, including ductal branching and cellular homeostasis with its absence leading to significant differential gene expression related to alveologenesis and lactogenesis and altered milk composition. Zfp57 dams attenuate offspring growth, with impacts on offspring metabolic health; effects exacerbated when pups are raised by a dam of a different genotype than their birth mother. The study identifies ZFP57 as a major regulator of both pre and postnatal resource control in mammals, offering new insights into early factors influencing lifelong health. - Source: PubMed
Publication date: 2026/01/27
Hanin GeulaAlSulaiti BoshraCostello Kevin RTavares HugoTakahashi NozomiMikheeva Liudmila AFreeman Anjuli KarmiPatel ShrinaJenkins BenjaminKoulman AlbertFerguson-Smith Anne C