ZFP57 Antibody
- Known as:
- ZFP57 Antibody
- Catalog number:
- GWB-C493B3
- Product Quantity:
- 0.1 mg
- Category:
- -
- Supplier:
- GenWay
- Gene target:
- ZFP57 Antibody
Related genes to: ZFP57 Antibody
- Gene:
- ZFP57 NIH gene
- Name:
- ZFP57 zinc finger protein
- Previous symbol:
- C6orf40
- Synonyms:
- ZNF698, bA145L22, bA145L22.2
- Chromosome:
- 6p22.1
- Locus Type:
- gene with protein product
- Date approved:
- 2003-11-26
- Date modifiied:
- 2018-11-22
Related products to: ZFP57 Antibody
Related articles to: ZFP57 Antibody
- Source: PubMed
- Common genetic variants are associated with risk of lung and autoimmune diseases. However, we have a limited understanding of the pathological effects of these disease variants, specifically in tissue-resident immune cells at the frontier of infection and disease in the lung. To address this, we performed single-cell expression quantitative trait locus (eQTL) analysis across 29 distinct immune cell subsets isolated from lung tissue. Colocalization analysis of lung immune cell eQTLs with genome-wide association study (GWAS) signals from lung diseases, and infectious and autoimmune diseases, implicate disease-associated variants and their target genes functioning in a single or restricted group of cell types. Several genes, including ZFP57, showed significant colocalization between lung immune cell eQTLs and GWAS signals from multiple systemic and organ-restricted autoimmune diseases, highlighting shared genetic mechanisms underlying the risk of disease. Overall, our study shows that disease-associated variants from a wide range of autoimmune diseases impact gene expression in tissue-resident immune cell types ( https://lung.dice-database.org ). - Source: PubMed
Publication date: 2026/08/03
Schmiedel Benjamin JGonzalez-Colin CristianFajardo-Rosas VicenteRocha JobSimon HayleyOttensmeier JohannesRamírez-Bernabé Ignacio ECano AprilDe la Cruz Castillo AngelMárquez-Gómez ElizabethHa BrendanGreenbaum Jason AChudley LindseyCave JudithAlzetani AimanWoo EdwinShackcloth MichaelChee Serena JChandra VivekKronenberg MitchellPeters BjoernOttensmeier Christian HGanesan Anusha-PreethiVijayanand Pandurangan - DNA methylation is one of the most important epigenetic processes that regulates gene expression. Although the human genome is predominantly methylated, CpG-rich regions known as CpG islands (CGIs) are typically unmethylated and are often sites of transcriptional control. Although the importance of CGIs and DNA methylation at the promoters is well understood, the significance of CGIs at the 3' ends remains largely unexplored. In this study, we characterised CGIs overlapping 3' untranslated regions (3'UTRs), compared them with CGIs located at the promoters, and examined their association with gene expression in cancer. We found that 3% of CGIs overlap 3'UTRs and have no annotated promoters in the vicinity. Unlike promoter CGIs, 3'UTR CGIs are shorter, less CpG-dense, but evolutionarily conserved. Although promoter CGIs typically stay unmethylated, those in 3'UTRs are often methylated and enriched for transcription factors like ZFP57, which target methylated motifs. These regions are linked to cancer signalling pathways, and their differential methylation in tumours correlates with gene expression changes, suggesting an underexplored regulatory role in cancer. - Source: PubMed
Publication date: 2026/07/24
Wilson ClaireKanhere Aditi - The biological mechanisms linking generalized anxiety disorder (GAD) and COVID-19 remain poorly understood, despite substantial evidence of their comorbidity. To address this gap, we examined genetic and epigenetic factors underlying their co-occurrence. - Source: PubMed
Publication date: 2026/06/04
Karaca SefayetCabrera Mendoza BrendaHe JunQiu DanDavtian DavidLacobelle AnnMarieNunez Yaira ZKrystal John HPietrzak Robert HGelernter JoelPolimanti Renato - Can single-cell, mass spectrometry-based proteomics identify proteins associated with reduced developmental competence of Patl2-/- Metaphase II (MII) mouse oocytes and reveal therapeutic targets for Patl2-related infertility? - Source: PubMed
Cardona Barberán AAraftpoor EChristodoulaki AFakhar-I-Adil MGoethals JRybouchkin AArnoult CBoel ABühler MPavani K CStoop DGevaert KVanden Meerschaut FHeindryckx B