Human PLRP1 / PNLIPRP1 Protein
- Known as:
- Human PLRP1 / PNLIPRP1 Protein
- Catalog number:
- PN1-H5229
- Product Quantity:
- 1mg
- Category:
- -
- Supplier:
- acrobyosystems
- Gene target:
- Human PLRP1 / PNLIPRP1 Protein
Related genes to: Human PLRP1 / PNLIPRP1 Protein
- Gene:
- PNLIPRP1 NIH gene
- Name:
- pancreatic lipase related protein 1
- Previous symbol:
- -
- Synonyms:
- PLRP1
- Chromosome:
- 10q25.3
- Locus Type:
- gene with protein product
- Date approved:
- 1994-04-28
- Date modifiied:
- 2016-10-05
Related products to: Human PLRP1 / PNLIPRP1 Protein
Related articles to: Human PLRP1 / PNLIPRP1 Protein
- Previous studies showed conflicting results regarding pioglitazone's effects on cardiac lipid metabolism. We aim to examine whether pioglitazone treatment predisposes or mitigates disrupted energy metabolism in cardiac intracellular lipid accumulation and the susceptibility to ventricular tachyarrhythmia. We used a rat model fed with a high-fat diet (HFD) and palmitate-treated cardiomyocytes to investigate whether pioglitazone administration affects disrupted energy metabolism and cardiac arrhythmia susceptibility. The HFD group had increased body weight, blood glucose, triglycerides, and cholesterol, as well as increased levels of HOMA-IR, leptin, and resistin in comparison to the control diet group. Sixteen-weeks pioglitazone (10 mg/kg/day) therapy in HFD rats resulted in improvements in triglyceride, blood glucose, and HOMA-IR compared to HFD rats. The HFD resulted in intracellular lipid droplet accumulation, oxidative stress, and increased cellular apoptosis. Comprehensive global ventricle metabolomic profiling revealed alterations in various diacylglycerols (DG), predominantly long-chain DGs ≥34 carbons, and dysregulation of key metabolic genes and enzymes. Notable gene/protein upregulation was observed in HMGCS2 (ketogenesis), PLPPR4 (regulation of phosphatic acid conversion to DG), PNLIPRP1 (TG hydrolysis), CES1C (TG hydrolysis), and ACSS2 (acetyl-CoA synthesis), while MVD/MVK (cholesterol synthesis) and PGAM2 (glycolysis) exhibited downregulation. The alternations in protein expression were partly restored with co-administration with pioglitazone. Palmitate administration in H9C2 and HL1 cardiac myocytes in vitro activated stress-responsive signaling cascades (p-ERK, p-JNK, p-CaMKII, and Caspase 3), resulting in cellular dysfunction, apoptosis, and increased calcium spark frequencies. Ex vivo, isolated HFD heart exhibited increased the frequency of ectopic focal activity and the vulnerability of ventricular fibrillation, which was mitigated by co-administration of pioglitazone. In conclusion, pioglitazone therapy may be a possible therapeutic strategy for obesity mediated cardiac lipotoxicity and arrhythmia. - Source: PubMed
Publication date: 2025/10/21
Yeh Yung-HsinCheng Mei-LingYang Cheng-HungChen Wei-JanChan Yi-Hsin - Type 1 diabetes is a chronic, autoimmune disease characterized by the destruction of insulin-producing β-cells in the pancreas. Early detection can facilitate timely intervention, potentially delaying or preventing disease onset. Circulating proteins reflect dysregulated biological processes and offer insights into early disease mechanisms. Here, we construct a genome-wide pQTL map of 1985 proteins in 695 newborn babies (median age 2 days) at increased genetic risk of developing Type 1 diabetes. We identify 535 pQTLs (352 cis-pQTLs, 183 trans-pQTLs), 62 of which characteristic of newborns. We show colocalization of pQTLs for CTRB1, APOBR, IL7R, CPA1, and PNLIPRP1 with Type 1 diabetes GWAS signals, and Mendelian randomization causally implicates each of these five proteins in the aetiology of Type 1 diabetes. Our study illustrates the utility of newborn molecular profiles for discovering potential drug targets for childhood diseases of significant concern. - Source: PubMed
Publication date: 2025/04/22
Tutino MauroYu Nancy Yiu-LinHatzikotoulas KonstantinosPark Young-ChanKreitmaier PeterKatsoula GeorgiaBerner ReinhardCasteels KristinaElding Larsson HelenaKordonouri OlgaOłtarzewski MariuszSzypowska AgnieszkaOtt RaffaelWeiss AndreasWinkler ChristianeZapardiel-Gonzalo JosePetrera AgneseHauck Stefanie MBonifacio EzioZiegler Anette-GabrieleZeggini Eleftheria - Understanding the genetic characteristics of indigenous goat breeds is vital for their conservation and breeding. Haimen goats, native to China's Yangtze River Delta, possess distinctive traits such as white hair, moderate growth rate, high-quality meat, and small body size. However, knowledge regarding the genetic structure and germplasm characteristics of Haimen goats remains limited. In this study, we performed 20× whole-genome resequencing of 90 goats (60 Haimen goats and 30 Boer goats) to identify single-nucleotide polymorphisms (SNPs) and insertions/deletions (Indels) associated with growth traits. Here, we analyzed population genetic structure and genome-wide selection signatures between the Haimen and Boer goats based on whole-genome resequencing data. The principal component analysis (PCA) and neighbor-joining (N-J) tree results demonstrated significant genetic differentiation between the Haimen and Boer goats. The nucleotide diversity (Pi) and linkage disequilibrium (LD) decay results indicated higher genomic diversity in the Haimen goat population. Furthermore, selective sweep analysis identified candidate genes associated with growth traits. These genes exhibited strong selection signatures and were related to body size (DONSON, BMPR1B, and EPHA5), muscle development (GART, VGLL3, MYH15), and fat metabolism (ADAMTS5, LRP6, XDH, CPT1A, and GPD1). We also identified growth-related candidate genes (NCOR1, DPP6, NOTCH2, and FGGY) specific to Haimen goats. Among these genes, pancreatic lipase-related protein 1 (PNLIPRP1) emerged as the primary candidate gene influencing growth phenotypes. Further analysis revealed that a 26 bp Indel in PNLIPRP1 increased its gene expression, suggesting that this Indel could serve as a molecular marker for early marker-assisted selection, potentially enhancing early growth in goats. These findings provide valuable molecular markers and candidate genes for improving growth traits in Haimen goat breeding. - Source: PubMed
Publication date: 2025/01/07
Zhang ZhenLu JiafengWang YifeiLiu ZhipengLi DongxuDeng KaipingZhang GuominZhao BingruYou PeihuaFan YixuanWang FengWang Ziyu - Berberine (BBR) is widely used to treat gastrointestinal diseases. However, the pharmacological mechanism of action of BBR in anti-chronic atrophic gastritis (CAG) remains unclear. This study aimed to investigate the mechanism of action of BBR in CAG by integration of molecular biology and multi-omics studies strategy. - Source: PubMed
Publication date: 2025/01/06
Chen LishengWang XinLi JianyuZhang LijuanWu WenbinWei ShizhangZou WenjunZhao Yanling - We postulated that type 2 diabetes (T2D) predisposes patients to exocrine pancreatic diseases through (epi)genetic mechanisms. We explored the methylome (using MethylationEPIC arrays) of the exocrine pancreas in 141 donors, assessing the impact of T2D. An epigenome-wide association study of T2D identified hypermethylation in an enhancer of the pancreatic lipase-related protein 1 (PNLIPRP1) gene, associated with decreased PNLIPRP1 expression. PNLIPRP1 null variants (found in 191,000 participants in the UK Biobank) were associated with elevated glycemia and LDL cholesterol. Mendelian randomization using 2.5M SNP Omni arrays in 111 donors revealed that T2D was causal of PNLIPRP1 hypermethylation, which in turn was causal of LDL cholesterol. Additional AR42J rat exocrine cell analyses demonstrated that Pnliprp1 knockdown induced acinar-to-ductal metaplasia, a known prepancreatic cancer state, and increased cholesterol levels, reversible with statin. This (epi)genetic study suggests a role for PNLIPRP1 in human metabolism and exocrine pancreatic function, with potential implications for pancreatic diseases. - Source: PubMed
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