Human pIgR Protein
- Known as:
- Human pIgR Protein
- Catalog number:
- PIR-H5222
- Product Quantity:
- 1mg
- Category:
- -
- Supplier:
- acrobyosystems
- Gene target:
- Human pIgR Protein
Related genes to: Human pIgR Protein
- Gene:
- PIGR NIH gene
- Name:
- polymeric immunoglobulin receptor
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 1q32.1
- Locus Type:
- gene with protein product
- Date approved:
- 1989-06-06
- Date modifiied:
- 2016-10-05
Related products to: Human pIgR Protein
Related articles to: Human pIgR Protein
- Intrahepatic cholestasis of pregnancy (ICP) is a gestational liver disorder characterized by maternal pruritus and elevated serum bile acids, which is associated with an increased risk of adverse fetal outcomes. The identification of stage-specific diagnostic markers of ICP is crucial for timely diagnosis and stratified intervention. - Source: PubMed
Publication date: 2026/04/10
Jiang YuxuanNie LeiLiang ZhiyuanHe LiShen LimingZhao Danqing - Cancer cells sustain glycolysis despite oxygen availability, creating an acidic microenvironment via proton and lactate export, but how they survive acid stress is unclear. We show that severe acidification (pH 5.6) induces necroptosis, whereas moderate acidity (pH 6.8) prevents death and enables anchorage-independent survival and tumor initiation. RNA sequencing of suspended cells at pH 6.8 revealed activation of respiratory chain complex and complement pathways, consistent with adaptation to this pH. A genome-wide CRISPR-Cas9 knockout screen in PANC1 cells under chronic acidity identified FAM129C as a regulator of acid tolerance and survival. In xenografts, FAM129C overexpression reduced PIGR expression, implicating this axis in tumor growth and immune infiltration. Anti-PD-L1 plus a complement inhibitor showed synergistic anti-tumor activity in PIGR-overexpressing tumors. Thus, acidic stress engages a pathway that allows cancer cells to evade necroptosis and promote tumor plasticity, providing potential avenues for therapeutic intervention targeting pH-dependent cell-death pathways. - Source: PubMed
Publication date: 2026/04/16
Hasegawa ManamiXu BoMaeda KeisukeSeki MotoakiCai FeiFeiCui RunmeiAndo RitsukoNakagawa SuzukaSakamoto AyanaBoycott CaylaYatabe HiroyukiNishida MiyukiMatsumoto KenIwabuchi-Yoshida ChisatoAki ShoYamagata KazuyukiTsuchida RikaTakahashi MamiKuribayashi FutoshiKidoya HiroyasuHirata HiroshiMatsumoto ShingoSando ShinsukeYanai HideyukiYachie NozomuOsawa Tsuyoshi - Osteoarthritis (OA) is characterized by inflammation-driven chondrocyte senescence and extracellular-matrix degradation. However, the molecular mechanisms linking inflammatory stress to chondrocyte aging remain poorly understood. Here, we identify cinnamyl alcohol (CA) as a natural small-molecule compound that attenuates OA progression through polymeric immunoglobulin receptor (PIGR)-mediated signaling . CA reduced inflammatory cytokine production, suppressed senescence-associated secretory phenotype gene expression, and preserved cartilage homeostasis in lipopolysaccharide- or interleukin-1β-stimulated chondrocytes. In a destabilization-of-the-medial-meniscus mouse model, intra-articular CA administration markedly alleviated cartilage degeneration and matrix loss. Integrating network pharmacology, molecular docking, and mass-spectrometry-based proteomic profiling, we identified PIGR as a convergent target of CA, validated by limited proteolysis (drug affinity responsive target stability) and loss-of-function assays. PIGR silencing abolished CA's antisenescent and cartilage-protective effects, confirming its essential role. Mechanistically, CA restored PIGR expression to modulate inflammatory signaling and maintain chondrocyte phenotype stability. These findings uncover a previously unrecognized CA-PIGR axis that couples inflammatory stress to cartilage aging and suggest CA as a promising natural therapeutic candidate for OA management. - Source: PubMed
Publication date: 2026/04/17
Zhu QiYou QingxiaDeng JiaojiaoTang HongtingHu YuhanLiao YuanmengMiao Ying - - Source: PubMed
Publication date: 2026/04/13
Luo GuoxiaDeng CongpoWen Bo - remains a pervasive aquatic pathogen precipitating catastrophic economic depletion and threats to global food security. Conventional therapeutic modalities are constrained by inadequate stability, prohibitive costs, and biosafety risks. - Source: PubMed
Publication date: 2026/03/23
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