Human IL-12B / NKSF2 / p40 Protein
- Known as:
- Human Interleukin-12B / NKSF2 / p40 Protein
- Catalog number:
- NK2-H52H7
- Product Quantity:
- 50ug
- Category:
- -
- Supplier:
- acrobyosystems
- Gene target:
- Human IL-12B / NKSF2 p40 Protein
Related genes to: Human IL-12B / NKSF2 / p40 Protein
- Gene:
- IL12B NIH gene
- Name:
- interleukin 12B
- Previous symbol:
- NKSF2
- Synonyms:
- CLMF, IL-12B, NKSF, CLMF2
- Chromosome:
- 5q33.3
- Locus Type:
- gene with protein product
- Date approved:
- 1991-08-08
- Date modifiied:
- 2019-04-23
Related products to: Human IL-12B / NKSF2 / p40 Protein
Related articles to: Human IL-12B / NKSF2 / p40 Protein
- Cutaneous leishmaniasis (CL) caused by results in chronic skin ulceration and remains challenging to treat. While human transcriptomic studies have identified pathways driving immunopathology, the early events of infection and the molecular transitions from lesion formation to healing are still poorly understood. Here, we performed a longitudinal transcriptomic analysis of skin lesions and draining lymph nodes (dLNs) in the BALB/c ear dermal model infected with , which recapitulates features of human CL. Using bulk RNA sequencing at 2, 6, and 48 hours and at 14, 35, and 77 days post-infection, we characterized differential gene expression, pathway enrichment, and gene co-expression networks. Ulcerated mouse lesions (Day 35) recapitulated 77% of the inflammatory pathways described in human CL, with many persisting at Day 77 despite "clinical healing". Mice displayed additional upregulation of genes linked to macrophage polarization (, , ), nitric oxide metabolism (, ) and epidermal differentiation (e.g., , , , members). Gene co-expression analysis revealed stage-specific gene modules (M) associated with early innate responses (M3), tissue damage (M1), epithelial-mesenchymal transition (M4), and skin barrier remodeling (M6). A long non-coding RNA-enriched module (M2) was selectively downregulated during the ulceration. Cross-species comparison of ulcerated lesions revealed 16 conserved microRNAs and 12 shared epigenetic regulators, including , , , and , with known roles in inflammation and tissue repair, representing promising host-directed therapeutic targets. Together, this study provides a comprehensive temporal framework of host responses to and identifies actionable non-coding RNAs and epigenetic pathways with translational potential for CL therapy. - Source: PubMed
Publication date: 2026/05/12
Lobo-Silva JessicaOrge CibeleNeto Almiro Pires da SilvaRibeiro Bruno VinagreFávaro Regiane Deganda Silva Joyce KarolineSantos Sara Patrícia de OliveiraNunes SaraMoitinho-Junior Valdomiro SilveiraBarral AldinaMachado Natalia TavaresRamos Pablo Ivan PereiraKhouri RicardoFarias Leonardo Paiva - Among individuals with neuropsychiatric disorders, those with bipolar disorder (BD) have one of the highest rates of suicide with this risk even further elevated in the Veteran population. The assessment of suicide risk is clinically challenging, but one of the best predictors of a future suicide attempt is having a prior attempt. Although prior studies have implicated proteomic abnormalities separately in BD and among those with a suicide attempt history, little is known regarding their combined contribution to suicide risk in BD and/or their relationship to the brain white matter. - Source: PubMed
Publication date: 2026/05/25
Szeszko Philip RChan Chi CRamakrishnan AarthiRizk MinaBaptista IsabelleAlter SharonHaznedar M MehmetChu King-WaiXie HuiYehuda RachelRusso Scott JShen LiRizakos TiaD'Souza DarwinFleysher LazarHazlett Erin AGoodman MarianneKim-Schulze SeungheeMurrough James W - Psoriasis is an autoimmune disorder, and about 125 million people worldwide suffer from this chronic skin disease. It is a multifactorial disorder influenced by the combined action of many genetic factors and their interactions with environmental factors. Recently, significant advances in research have provided greater insight into the pathophysiologic mechanisms, highlighting the roles of genetic susceptibility loci such as HLA-C*06:02, IL12B, and TNIP1, as well as immune pathways involving IL-17, IL-23, and TNF-α. These discoveries not only provided a better understanding of psoriasis but also played a vital role in developing treatment strategies. This review highlights immunological and genetic insights of psoriasis, emphasising their translational relevance. The review also covers how genetic variations modulate the immune response, leading to disease occurrence and chronicity. Moreover, the article explores how these findings are shaping personalised diagnosis and treatment strategies. This strategy holds the promise of enhancing the treatment of individuals with psoriasis by transitioning from the traditional care paradigm to patient-centred care in dermatology. - Source: PubMed
Publication date: 2026/05/13
Sugumaran DineshwarYong Audrey Chee HuiHow Kang NienStanslas Johnson - Major traumatic life events are risk factors for stress-related neuropsychiatric disorders, often accompanied by systemic inflammation, neuroinflammation, and microglial priming. As systemic inflammation, neuroinflammation, and microglial priming are considered risk factors for developing stress-related psychiatric disorders, one novel therapeutic strategy is to identify interventions that mitigate these responses. In this study, we investigated the effects of a novel soil-derived Mycolicibacterium, Mycolicibacterium sp. strain KGA-10, on in vitro immunoregulatory potential in murine bone marrow-derived dendritic cells (BMDCs) and on biomarkers of systemic inflammation, biomarkers of hippocampal neuroinflammation and microglial priming, and anxiety-like defensive behavioral responses in adult male rats exposed to inescapable tail-shock stress (IS). In Experiments 1, 2, and 3, BMDCs were exposed to the type strain, Mycolicibacterium vaccae ATCC 15483 (0, 10, 30, 100, 300 µg/mL; Experiment 1) or M. sp. strain KGA-10 (100 µg/mL; Experiments 2 and 3) or sterile borate-buffered saline (BBS) vehicle followed, 24 h later, by exposure to lipopolysaccharide (LPS; 250 ng/mL) or a cell culture media vehicle, then, 24 h later, assessed for Il10, Il12a, and Il12b mRNA expression. Exposure of murine BMDCs to M. vaccae ATCC 15483 or M. sp. strain KGA-10 induced an immunoregulatory phenotype, characterized by increased ratios of Il10:Il12a and Il10:Il12b mRNA expression in both naïve and lipopolysaccharide- (LPS; 250 ng/mL) challenged conditions. In Experiment 3, adult male rats received weekly injections of heat-killed M. sp. strain KGA-10 (0.1 mg/0.1 mL, s.c.) or sterile BBS vehicle over three weeks prior to IS. Anxiety-like defensive behavioral responses were assessed 24 h following IS or home cage control conditions using the juvenile social exploration (JSE) test, while biomarkers of hippocampal neuroinflammation and microglial priming were assessed using real-time reverse transcription - polymerase chain reaction (real-time RT-PCR). M. sp. strain KGA-10 treatment promoted an anti-inflammatory immunophenotype, evidenced by decreased hippocampal Il12a, and decreased biomarkers of microglial priming, Nfkbia and Nlrp3 mRNA expression among rats exposed to IS, in association with prevention of IS-induced increases in anxiety-like defensive responses in the JSE test. These findings suggest that M. sp. strain KGA-10 is a promising candidate for a novel intervention for promotion of stress resilience and prevention of stress-related psychiatric disorders. - Source: PubMed
Publication date: 2026/05/11
Zhang HaotingMarquart Brandon MHolbrook Evan MWright Caelan T OZambrano Cristian AGebert Matthew JDawud Lamya'a MAndersen Nathan DKessler Lyanna RSago Saydie ACole Echo YCostanza-Chavez Gabriel WBaratta Michael VFrank Matthew GMacDonald Andrew SStamper Christopher EBohr Adam DFierer NoahLowry Christopher A - Inclusion body myositis (IBM) is an idiopathic inflammatory myopathy characterised by type 1 inflammation, driven by muscle-infiltrating KLRG1+ and TBX21+ cytotoxic T cells. However, the cellular sources of the stimuli that trigger this effector response in the muscle of patients with IBM remain unclear. Given their role as antigen-presenting cells, we hypothesised that these may be myeloid dendritic cells (mDCs), which have previously been reported in skeletal muscle of patients with IBM. We used immunohistochemistry, immunofluorescence, single-nucleus RNA-sequencing (snRNA-seq) and bulk RNA-sequencing (RNA-seq) data from skeletal muscle of patients with IBM, other myositis, and controls to identify mDCs and characterise their contribution to IBM inflammation. - Source: PubMed
Publication date: 2026/05/05
Kirou Raphael APinal-Fernandez IagoCasal-Dominguez MariaPak KatherineIkenaga ChisekoNelke ChristopherWischnewski SvenPreusse CorinnaDel Orso StefaniaNaz FaizaIslam ShamimaGutierrez-Cruz GustavoLloyd Thomas ESchirmer LucasRuck TobiasStenzel WernerSelva-O'Callaghan AlbertMilisenda Jose CMammen Andrew L