Human LYPD3 / C4.4A Protein
- Known as:
- Human LYPD3 / C4.4A Protein
- Catalog number:
- LY3-H52H5
- Product Quantity:
- 1mg
- Category:
- -
- Supplier:
- acrobyosystems
- Gene target:
- Human LYPD3 / C4.4A Protein
Related genes to: Human LYPD3 / C4.4A Protein
- Gene:
- LYPD3 NIH gene
- Name:
- LY6/PLAUR domain containing 3
- Previous symbol:
- -
- Synonyms:
- C4.4A
- Chromosome:
- 19q13.31
- Locus Type:
- gene with protein product
- Date approved:
- 2005-08-30
- Date modifiied:
- 2015-07-22
Related products to: Human LYPD3 / C4.4A Protein
Related articles to: Human LYPD3 / C4.4A Protein
- To explore the relationship between surfactant protein B (SFTPB) gene expression and multiple biological processes in lung adenocarcinoma (LUAD) and construct a SFTPB-related gene signature for predicting LUAD prognosis. - Source: PubMed
Publication date: 2026/03/22
Ma ShanwuXu RuiLin ChutongNing YingzeHe HuayuTang JizhengJin LiangHe WeiXiong ZhenchengQiang Guangliang - This study investigates the therapeutic mechanisms of electroacupuncture (EA) in regulating the vagal nerve for functional dyspepsia (FD) using an integrated multi-omics approach. - Source: PubMed
Publication date: 2026/03/09
Zhang XuepingHu XinxinLi JiaxuanSong XiaojingWang ChengxiangChen YangWu SuoweiMa LixinJiang WenqiCai RanSu XiaolanWei Wei - Esophageal squamous cell carcinoma (ESCA) is a highly aggressive malignancy with substantial heterogeneity and poor prognosis. Polyamine metabolism has been implicated in tumor progression and immune regulation, yet its specific role in ESCA remains unclear. Here, we performed integrative single-cell and bulk transcriptomic analyses to explore the significance of polyamine metabolism in ESCA. Using single-cell RNA-seq data from four ESCA patients (GSE188900), we identified seven major cell populations and evaluated polyamine activity via gene set scoring. B lymphocytes and myeloid cells exhibited the highest polyamine scores. Differential expression and enrichment analyses between Polyamine-High and -Low groups revealed associations with immune-related pathways, including T cell activation and cell adhesion. From these genes, we developed a prognostic model consisting of eight polyamine-associated genes (LYPD3, DHPS, MUC5B, CXCL14, SQSTM1, RUNX3, PTPRC, and KRT14) using Cox and LASSO regression. The model effectively stratified patients into high- and low-risk groups in both the GSE53624 training and GSE53622 validation cohorts, with the high-risk group showing significantly worse survival. Immune infiltration analysis using MCPcounter, xCell, and ssGSEA showed distinct immune landscapes across risk groups, with low-risk patients exhibiting higher neutrophil and type 2 helper T cell infiltration. Drug sensitivity analysis based on oncoPredict revealed compounds with differential efficacy between risk groups, and the model also predicted response to PD-1 blockade in an external immunotherapy cohort. In summary, polyamine metabolism is closely linked to the immune microenvironment and prognosis of ESCA, providing a potential biomarker for patient stratification and treatment optimization. - Source: PubMed
Publication date: 2026/02/19
Cao XiuliChen YuanyuanLi TaoWei Jinxing - As a major disease that seriously threatens human health, the prevention and control of malignant tumors has become an important challenge for global public health. In this study, we first investigated the expression level, prognostic value, and diagnostic value of LYPD3 in pan-cancer, and its effects on the immune microenvironment, genetic variation, and antitumor drug sensitivity. RT-PCR and western blot were used to detect the transfection efficiency. Cell apoptosis was detected by flow cytometry. Transwell assay for detection of cell invasion and migration. Western blot was used to detect the expression of Bax, Bcl-2, E-cadherin, N-cadherin and Vimentin. LYPD3 showed high expression in lung cancer, both at the mRNA and protein level. Single-cell transcriptome and spatial transcriptomics reveal that LYPD3 is highly expressed in tumor cells and tumor-associated fibroblasts. ROC analysis revealed that LYPD3 exhibited significant diagnostic efficacy in pan-cancer, and Cox regression analysis revealed that LYPD3 expression was significantly associated with the risk of death in certain cancer types. LYPD3 has a good diagnostic value and prognostic predictive value in pan-cancer. GDSC and CTRP data analysis confirmed that LYPD3 expression was negatively correlated with the drug sensitivity of lapatinib, erlotinib, and afatinib. Focusing on the expression of LYPD3 in lung cancer, cellular experiments revealed that LYPD3 promotes lung cancer cell invasion and metastasis while inhibiting apoptosis. Meanwhile, LYPD3 has a good diagnostic value and prognostic prediction value. - Source: PubMed
Publication date: 2026/01/19
Shi Yuan-XiangYan Jian-HuaDai Peng-Hui - Despite advances in EGFR-TKIs for lung adenocarcinoma (LUAD), resistance remains a major hurdle. This study aimed to develop a prognostic model integrating immune microenvironment features and resistance mechanisms to predict outcomes and guide therapy. - Source: PubMed
Publication date: 2025/11/21
Li JunnanZhang JiashengZhang XinyangCao ChengwuZhou TianjieLiu FengxianHu LiqingKwok Hang FaiZou Hui