Human Insulin R / CD220 (28-956) Protein
- Known as:
- Human Insulin R / CD220 (28-956) Protein
- Catalog number:
- INR-H5220
- Product Quantity:
- 1mg
- Category:
- -
- Supplier:
- acrobyosystems
- Gene target:
- Human Insulin / CD220 (28-956) Protein
Related genes to: Human Insulin R / CD220 (28-956) Protein
- Gene:
- INSR NIH gene
- Name:
- insulin receptor
- Previous symbol:
- -
- Synonyms:
- CD220
- Chromosome:
- 19p13.2
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2017-07-07
Related products to: Human Insulin R / CD220 (28-956) Protein
Related articles to: Human Insulin R / CD220 (28-956) Protein
- Calorie restriction (CR) is a well-established non-genetic intervention for lifespan extension in multiple model organisms. Seasonal food shortage in cold and temperate seas may mimic CR, inducing in bivalves a response similar to that in vertebrates and thereby prolonging life expectancy. However, the relationship and the mechanism underlying the food availability and lifespan in bivalves remain largely unexplored. Two closely related scallop species the short-lived warm-water Argopecten irradians (lifespan <2 years) and the longer-lived cold-water Argopecten purpuratus (7-10 years) provide an ideal comparative system to investigate species-specific adaptive strategies. In this study, we subjected both species to CR for 30 and 56 days and performed comparative transcriptomic profiling, weighted gene co-expression network analysis (WGCNA), and physiological assays to elucidate their distinct molecular responses. Transcriptomic analysis revealed that A. purpuratus exhibited substantially more DEGs than A. irradians at both time points under CR, with both species showing downregulation of metabolic pathways but to different extents. A. irradians mounted an early nutrient-sensing response at 30 days (IGF1R, PIK3R3, INSR suppression), indicating acute sensitivity to limitation; by contrast, A. purpuratus displayed delayed FoxO activation at 56 days, along with its downstream effectors NFKBIA, CREB3L4, and SMAD4, suggesting a gradual adaptive program may link to its extended lifespan. WGCNA identified three negatively correlated modules in each species, with coral2 being the most prominent in A. irradians and darkolivegreen in A. purpuratus. The former was dominated by ciliary motility genes, whereas the latter featured coordinated repression of oxidative phosphorylation. Additionally, both species exhibited conserved suppression of mTOR/S6K growth signaling and activation of cellular maintenance programs. Collectively, these findings expand the understanding of CR-mediated longevity regulation in bivalves and provide candidate gene resources for future functional studies and breeding programs. - Source: PubMed
Publication date: 2026/08/10
Zhao YangZhang JilinLiu ChangdaWang ChunyeShao XiangXu XinWang Chunde - This study investigated how graded dietary metabolizable energy (ME) levels affect growth performance, and metabolic regulation in broilers, with particular focus on oxidative status, hepatic metabolism, and gut microbiota. A total of 480 one-day-old male AA broilers were reared under standard conditions until 21 days of age, after which they were assigned to four dietary treatments containing 3050, 3150, 3250, or 3350 kcal/kg. Growth performance was not significantly affected by dietary ME, as body weight, average daily gain, average daily feed intake, and feed conversion ratio were similar among treatments (P > 0.05). However, dietary ME significantly influenced relative gizzard weight and immune organ indices, including the thymus, spleen, and bursa of Fabricius (P < 0.05). Higher dietary ME enhanced antioxidant capacity, reflected by increased serum SOD and GSH-Px activities, while TNF-α decreased with increasing ME (P < 0.05). Liver expression of genes involved in glucose metabolism, lipid metabolism, and insulin signaling was modulated by dietary ME. In the ileum, FABP6 expression increased with increasing dietary ME (P < 0.05), whereas FBP1 and INSR expression decreased (P < 0.05). Collectively, these findings suggest that moderate dietary ME levels may support metabolic stability and antioxidant capacity without affecting growth performance. - Source: PubMed
Publication date: 2026/07/28
Wu XingyueWang LeileiChen YuelongHuang YanqunZhang HuaiyongZheng RuiLiu SiqiangFeng ZikeChen WenSi Xuemeng - Lupus nephritis (LN) is a severe complication of systemic lupus erythematosus (SLE), leading to progressive renal fibrosis and functional decline. Understanding the interplay between immune cells and stromal cells is needed to develop effective therapeutic strategies. In this study, we investigated the landscape of macrophage-fibroblast interactions in human LN and validated these findings in mouse models. - Source: PubMed
Publication date: 2026/08/13
Raparia ChiragHoover PaulAi JuntingClark MarcusShah Sujal Diamond BettyHacohen NirArazi ArnonDavidson Anne - Cystic echinococcosis, caused by the larval stage of Echinococcus granulosus, predominantly affects the liver. Components of hydatid cyst fluid (HCF), including extracellular vesicles (EVs), have been suggested to participate in host-parasite communication. The present study investigated whether HCF and EVs derived from it can influence insulin-related genes in hepatocyte cells. EVs were isolated from the HCF obtained from the liver of an infected sheep using differential centrifugation and were characterized by western blotting, scanning electron microscopy (SEM), dynamic light scattering (DLS), and zeta potential analysis. HepG2 cells were treated with EVs and HCF for 24 and 48 h. The expression of insulin-related genes, including INSR, AKT, IDE, and INSIG2, was then evaluated by quantitative real-time PCR. EV significantly up-regulated AKT (1.98 ± 0.17, p < 0.0001), INSR (2.09 ± 0.34, P = 0.0008), IDE (1.40 ± 0.17, P = 0.0031), and INSIG2 (1.67 ± 0.17, P = 0.0005) at 24 h; however, at 48 h, AKT (-2.68 ± 0.4), INSR (-3.75 ± 0.4), and IDE (-3.6 ± 0.93) were significantly down-regulated (all P < 0.0001), while INSIG2 remained up-regulated (3.81 ± 0.85, P = 0.0006). In contrast, HCF exposure predominantly caused gene down-regulation, with significant decreases in AKT (-1.41 ± 0.4), INSR (-1.9 ± 0.72), and IDE (-1.6 ± 0.34) at 24 h (all P ≤ 0.0002) and a more pronounced downregulation of all genes at 48 h, including AKT (-6.67 ± 1.56), INSR (-5.89 ± 0.76), IDE (-6.8 ± 1.2), and INSIG2 (-1.16 ± 0.06) (all P < 0.0001). Our findings showed that exposure to EVs was associated with reduced expression of INSR and AKT and increased expression of IDE and INSIG2. This metabolic reprogramming appears to be a coordinated strategy to divert host energetic resources to favor parasite survival. - Source: PubMed
Publication date: 2026/08/10
Zanjirani Farahani LeyliRouhani SoheilaNiyyati MaryamEslami NasimFasihi Harandi MajidMirjalali Hamed - Diabetic retinopathy (DR) requires robust biomarkers. To overcome the limitations of bulk sequencing, we integrated single-cell eQTL mapping with Mendelian randomization to identify causal cell populations and genes. CD8 Teff cells were expanded in peripheral blood, showing elevation in non-DR diabetes and reaching maximal levels in DR. Mendelian randomization analysis implicated IL2RB as a putative causal marker, with the lead eQTL SNP rs3184504 demonstrating strong association ( = 8.5467 × 10). Colocalization analysis with DR GWAS and validation in bulk data reinforced this signal. In tissues, CellChat predicted more interactions for IL2RB compared to IL2RB CD8 Teff cells, including IL16-CD4 with macrophages and NAMPT interactions with both ITGA5+ITGB1 and INSR on endothelial cells, implicating immune-vascular regulation. Together, these findings nominate IL2RB as a biomarker and therapeutic target while clarifying mechanisms underlying DR. - Source: PubMed
Publication date: 2026/08/05
Cao LizhiWang ZumingCai XiaoweiZhou YongkangYan Yu